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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model

Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
Drug Metabolism and Disposition November 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867

Article Information

vol. 46 no. 11 1617-1625
DOI 
https://doi.org/10.1124/dmd.118.082867
PubMed 
30135244
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 1, 2018
  • Accepted August 15, 2018
  • Published online October 17, 2018.

Article Versions

Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Richard D. Burton,
  2. Todd Hieronymus,
  3. Taysir Chamem,
  4. David Heim,
  5. Shelby Anderson,
  6. Xiaochun Zhu, and
  7. J. Matthew Hutzler
  1. Q2 Solutions, a Quintiles Quest Joint Venture, Bioanalytical and ADME Laboratories, Indianapolis, Indiana
  1. Address correspondence to:
    Dr. J. Matthew Hutzler, Q2 Solutions, Bioanalytical and ADME Laboratories, 5225 Exploration Drive, Indianapolis, IN 46241. E-mail: matt.hutzler{at}Q2LabSolutions.com
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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

Human Drug Metabolism in HµREL Hepatocyte Coculture

Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867
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