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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport
Open Access

Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?

J. Gerry Kenna and Jack Uetrecht
Drug Metabolism and Disposition November 2018, 46 (11) 1658-1669; DOI: https://doi.org/10.1124/dmd.118.082719
J. Gerry Kenna
Safer Medicines Trust, Kingsbridge, United Kingdom (J.G.K.); and Faculties of Pharmacy and Medicine, University of Toronto, Toronto, Ontario, Canada (J.U.)
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Jack Uetrecht
Safer Medicines Trust, Kingsbridge, United Kingdom (J.G.K.); and Faculties of Pharmacy and Medicine, University of Toronto, Toronto, Ontario, Canada (J.U.)
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Article Information

vol. 46 no. 11 1658-1669
DOI 
https://doi.org/10.1124/dmd.118.082719
PubMed 
30021844

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 30, 2018
  • Accepted July 5, 2018
  • Published online October 17, 2018.

Article Versions

  • Earlier version (July 18, 2018 - 09:35).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. J. Gerry Kenna and
  2. Jack Uetrecht
  1. Safer Medicines Trust, Kingsbridge, United Kingdom (J.G.K.); and Faculties of Pharmacy and Medicine, University of Toronto, Toronto, Ontario, Canada (J.U.)
  1. Address correspondence to:
    Jack Uetrecht, Pharmaceutical Sciences, Faculties of Pharmacy and Medicine, University of Toronto, 144 College St., Toronto, ON M5S 3M2, Canada. E-mail: jack.uetrecht{at}utoronto.ca
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Drug Metabolism and Disposition: 46 (11)
Drug Metabolism and Disposition
Vol. 46, Issue 11
1 Nov 2018
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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

Do In Vitro Assays Predict Idiosyncratic Drug Reaction Risk?

J. Gerry Kenna and Jack Uetrecht
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1658-1669; DOI: https://doi.org/10.1124/dmd.118.082719

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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

Do In Vitro Assays Predict Idiosyncratic Drug Reaction Risk?

J. Gerry Kenna and Jack Uetrecht
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1658-1669; DOI: https://doi.org/10.1124/dmd.118.082719
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    • Visual Overview
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    • Cytotoxicity Assays
    • Covalent Binding Assays
    • Mitochondrial Injury
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