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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport
Open Access

Fabrication of a Corneal Model Composed of Corneal Epithelial and Endothelial Cells via a Collagen Vitrigel Membrane Functioned as an Acellular Stroma and Its Application to the Corneal Permeability Test of Chemicals

Hiroyuki Yamaguchi and Toshiaki Takezawa
Drug Metabolism and Disposition November 2018, 46 (11) 1684-1691; DOI: https://doi.org/10.1124/dmd.118.080820
Hiroyuki Yamaguchi
Division of Biotechnology, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan (H.Y., T.T.); and Isehara Research Laboratory, Technology and Development Division, Kanto Chemical Co., Inc., Isehara, Kanagawa, Japan (H.Y.)
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Toshiaki Takezawa
Division of Biotechnology, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan (H.Y., T.T.); and Isehara Research Laboratory, Technology and Development Division, Kanto Chemical Co., Inc., Isehara, Kanagawa, Japan (H.Y.)
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Article Information

vol. 46 no. 11 1684-1691
DOI 
https://doi.org/10.1124/dmd.118.080820
PubMed 
29844140

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 4, 2018
  • Accepted May 21, 2018
  • Published online October 17, 2018.

Article Versions

  • Earlier version (May 29, 2018 - 07:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 The Author(s). This is an open access article distributed under the CC BY Attribution 4.0 International license.

Author Information

  1. Hiroyuki Yamaguchi and
  2. Toshiaki Takezawa
  1. Division of Biotechnology, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan (H.Y., T.T.); and Isehara Research Laboratory, Technology and Development Division, Kanto Chemical Co., Inc., Isehara, Kanagawa, Japan (H.Y.)
  1. Address correspondence to:
    Dr. Toshiaki Takezawa, Division of Biotechnology, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization, 1-2 Ohwashi, Tsukuba, Ibaraki 305-8634, Japan. E-mail: t.takezawa{at}affrc.go.jp
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Drug Metabolism and Disposition: 46 (11)
Drug Metabolism and Disposition
Vol. 46, Issue 11
1 Nov 2018
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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

Corneal Model Useful for the Permeability Test of Chemicals

Hiroyuki Yamaguchi and Toshiaki Takezawa
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1684-1691; DOI: https://doi.org/10.1124/dmd.118.080820

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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

Corneal Model Useful for the Permeability Test of Chemicals

Hiroyuki Yamaguchi and Toshiaki Takezawa
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1684-1691; DOI: https://doi.org/10.1124/dmd.118.080820
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