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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport
Open Access

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson
Drug Metabolism and Disposition November 2018, 46 (11) 1776-1786; DOI: https://doi.org/10.1124/dmd.118.082842
M. Karlgren
Department of Pharmacy (M.Ka., P.A.), Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy (I.S.), and Science for Life Laboratory (P.A.), Uppsala University, Uppsala, Sweden; and Department of Clinical Pharmacology, Center of Drug Absorption and Transport, University Medicine of Greifswald, Germany (M.Ke., S.O.)
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I. Simoff
Department of Pharmacy (M.Ka., P.A.), Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy (I.S.), and Science for Life Laboratory (P.A.), Uppsala University, Uppsala, Sweden; and Department of Clinical Pharmacology, Center of Drug Absorption and Transport, University Medicine of Greifswald, Germany (M.Ke., S.O.)
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M. Keiser
Department of Pharmacy (M.Ka., P.A.), Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy (I.S.), and Science for Life Laboratory (P.A.), Uppsala University, Uppsala, Sweden; and Department of Clinical Pharmacology, Center of Drug Absorption and Transport, University Medicine of Greifswald, Germany (M.Ke., S.O.)
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S. Oswald
Department of Pharmacy (M.Ka., P.A.), Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy (I.S.), and Science for Life Laboratory (P.A.), Uppsala University, Uppsala, Sweden; and Department of Clinical Pharmacology, Center of Drug Absorption and Transport, University Medicine of Greifswald, Germany (M.Ke., S.O.)
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P. Artursson
Department of Pharmacy (M.Ka., P.A.), Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy (I.S.), and Science for Life Laboratory (P.A.), Uppsala University, Uppsala, Sweden; and Department of Clinical Pharmacology, Center of Drug Absorption and Transport, University Medicine of Greifswald, Germany (M.Ke., S.O.)
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Article Information

vol. 46 no. 11 1776-1786
DOI 
https://doi.org/10.1124/dmd.118.082842
PubMed 
30126863

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 1, 2018
  • Accepted August 3, 2018
  • Published online October 17, 2018.

Article Versions

  • Earlier version (August 20, 2018 - 09:32).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. M. Karlgren,
  2. I. Simoff,
  3. M. Keiser,
  4. S. Oswald, and
  5. P. Artursson
  1. Department of Pharmacy (M.Ka., P.A.), Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy (I.S.), and Science for Life Laboratory (P.A.), Uppsala University, Uppsala, Sweden; and Department of Clinical Pharmacology, Center of Drug Absorption and Transport, University Medicine of Greifswald, Germany (M.Ke., S.O.)
  1. Address correspondence to:
    Dr. Maria Karlgren, Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden. E-mail: maria.karlgren{at}farmaci.uu.se
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Drug Metabolism and Disposition: 46 (11)
Drug Metabolism and Disposition
Vol. 46, Issue 11
1 Nov 2018
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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

CRISPR-Cas9 in Drug Metabolism and Disposition

M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1776-1786; DOI: https://doi.org/10.1124/dmd.118.082842

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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

CRISPR-Cas9 in Drug Metabolism and Disposition

M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1776-1786; DOI: https://doi.org/10.1124/dmd.118.082842
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  • Article
    • Abstract
    • Introduction
    • How Does CRISPR-Cas9 Work?
    • CRISPR-Cas9 for Generating ADME Models
    • Limitations of CRISPR-Cas9
    • Future Applications for CRISPR-Cas9 within the ADME Field
    • Acknowledgments
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