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Drug Metabolism & Disposition

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Table of Contents

December 01, 2018; Volume 46,Issue 12

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    Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics
    Niall Heyes, Parth Kapoor and Ian D. Kerr
    Drug Metabolism and Disposition December 2018, 46 (12) 1886-1899; DOI: https://doi.org/10.1124/dmd.118.083030

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    6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol
    Kimberly Lapham, Jian Lin, Jonathan Novak, Christine Orozco, Mark Niosi, Li Di, Theunis C. Goosen, Sangwoo Ryu, Keith Riccardi, Heather Eng, Kimberly O. Cameron and Amit S. Kalgutkar
    Drug Metabolism and Disposition December 2018, 46 (12) 1836-1846; DOI: https://doi.org/10.1124/dmd.118.083709
  • Metabolism of c-Met Kinase Inhibitors Containing Quinoline by Aldehyde Oxidase, Electron Donating, and Steric Hindrance Effect
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    Metabolism of c-Met Kinase Inhibitors Containing Quinoline by Aldehyde Oxidase, Electron Donating, and Steric Hindrance Effect
    Jiang Wei Zhang, Wen Xiao, Zhen Ting Gao, Zheng Tian Yu and Ji Yue (Jeff) Zhang
    Drug Metabolism and Disposition December 2018, 46 (12) 1847-1855; DOI: https://doi.org/10.1124/dmd.118.081919
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    Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells
    Kee W. Tan, Angelina Sampson, Bremansu Osa-Andrews and Surtaj H. Iram
    Drug Metabolism and Disposition December 2018, 46 (12) 1856-1866; DOI: https://doi.org/10.1124/dmd.118.081612
  • Open Access
    Identification and Quantification of Novel Major Metabolites of the Steroidal Aromatase Inhibitor, Exemestane
    Shaman Luo, Gang Chen, Cristina I. Truica, Cynthia C. Baird, Zuping Xia and Philip Lazarus
    Drug Metabolism and Disposition December 2018, 46 (12) 1867-1878; DOI: https://doi.org/10.1124/dmd.118.081166
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    Regional Differences in Human Intestinal Drug Metabolism
    Raditya Iswandana, Marina I. Irianti, Dorenda Oosterhuis, Hendrik S. Hofker, Marjolijn T. Merema, Marina H. de Jager, Henricus A. M. Mutsaers and Peter Olinga
    Drug Metabolism and Disposition December 2018, 46 (12) 1879-1885; DOI: https://doi.org/10.1124/dmd.118.083428
  • Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance
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    Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance
    Dennis R. Goulet, Michael J. Watson, Susan H. Tam, Adam Zwolak, Mark L. Chiu, William M. Atkins and Abhinav Nath
    Drug Metabolism and Disposition December 2018, 46 (12) 1900-1907; DOI: https://doi.org/10.1124/dmd.118.081893
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In this issue

Drug Metabolism and Disposition: 46 (12)
Drug Metabolism and Disposition
Vol. 46, Issue 12
1 Dec 2018
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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