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Drug Metabolism & Disposition

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Table of Contents

February 01, 2018; Volume 46,Issue 2

Editorial

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    Editorial
    Jeffrey C. Stevens
    Drug Metabolism and Disposition February 2018, 46 (2) 88; DOI: https://doi.org/10.1124/dmd.117.079772

Articles

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    Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio
    R. Scott Obach, Jian Lin, Emi Kimoto, Sridhar Duvvuri, Timothy Nicholas, Eugene P. Kadar, Larry M. Tremaine and Aarti Sawant-Basak
    Drug Metabolism and Disposition February 2018, 46 (2) 89-99; DOI: https://doi.org/10.1124/dmd.117.078279
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    Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation
    Michael Z. Liao, Chunying Gao, Brian R. Phillips, Naveen K. Neradugomma, Lyrialle W. Han, Deepak Kumar Bhatt, Bhagwat Prasad, Danny D. Shen and Qingcheng Mao
    Drug Metabolism and Disposition February 2018, 46 (2) 100-108; DOI: https://doi.org/10.1124/dmd.117.076745
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    Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin
    Helen Gu, Catherine Dutreix, Sam Rebello, Taoufik Ouatas, Lai Wang, Dung Yu Chun, Heidi J. Einolf and Handan He
    Drug Metabolism and Disposition February 2018, 46 (2) 109-121; DOI: https://doi.org/10.1124/dmd.117.078006
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    Effect of Probiotics on Pharmacokinetics of Orally Administered Acetaminophen in Mice
    Jeon-Kyung Kim, Min Sun Choi, Jin-Ju Jeong, Su-Min Lim, In Sook Kim, Hye Hyun Yoo and Dong-Hyun Kim
    Drug Metabolism and Disposition February 2018, 46 (2) 122-130; DOI: https://doi.org/10.1124/dmd.117.077222
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    The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes
    Marie Febvre-James, Arnaud Bruyère, Marc Le Vée and Olivier Fardel
    Drug Metabolism and Disposition February 2018, 46 (2) 131-140; DOI: https://doi.org/10.1124/dmd.117.078048
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    Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions 
    Helinä Kahma, Anne M. Filppula, Mikko Neuvonen, E. Katriina Tarkiainen, Aleksi Tornio, Mikko T. Holmberg, Matti K. Itkonen, Moshe Finel, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
    Drug Metabolism and Disposition February 2018, 46 (2) 141-150; DOI: https://doi.org/10.1124/dmd.117.078162
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    Toxicokinetics and Physiologically Based Pharmacokinetic Modeling of the Shellfish Toxin Domoic Acid in Nonhuman Primates
    Jing Jing, Rebekah Petroff, Sara Shum, Brenda Crouthamel, Ariel R. Topletz, Kimberly S. Grant, Thomas M. Burbacher and Nina Isoherranen
    Drug Metabolism and Disposition February 2018, 46 (2) 155-165; DOI: https://doi.org/10.1124/dmd.117.078485
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    Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes
    Michelle Schaefer, Gaku Morinaga, Akiko Matsui, Gerhard Schänzle, Daniel Bischoff and Roderich D. Süssmuth
    Drug Metabolism and Disposition February 2018, 46 (2) 166-177; DOI: https://doi.org/10.1124/dmd.117.078238
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    Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys
    Hong Shen, David M. Nelson, Regina V. Oliveira, Yueping Zhang, Colleen A. Mcnaney, Xiaomei Gu, Weiqi Chen, Ching Su, Michael D. Reily, Petia A. Shipkova, Jinping Gan, Yurong Lai, Punit Marathe and W. Griffith Humphreys
    Drug Metabolism and Disposition February 2018, 46 (2) 178-188; DOI: https://doi.org/10.1124/dmd.117.077586
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    Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics
    Sarah Billington, Adrian S. Ray, Laurent Salphati, Guangqing Xiao, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Caroline A. Lee, Anita Mathias, Cornelis E. C. A. Hop, Christopher Rowbottom, Raymond Evers, Yurong Lai, Edward J. Kelly, Bhagwat Prasad and Jashvant D. Unadkat
    Drug Metabolism and Disposition February 2018, 46 (2) 189-196; DOI: https://doi.org/10.1124/dmd.117.077289

Short Communication

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    Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood
    Jin-Zi Ji, Ting Tai, Bei-Bei Huang, Tong-Tong Gu, Qiong-Yu Mi and Hong-Guang Xie
    Drug Metabolism and Disposition February 2018, 46 (2) 151-154; DOI: https://doi.org/10.1124/dmd.117.078329
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Drug Metabolism and Disposition: 46 (2)
Drug Metabolism and Disposition
Vol. 46, Issue 2
1 Feb 2018
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