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Research ArticleArticle

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys

Hong Shen, David M. Nelson, Regina V. Oliveira, Yueping Zhang, Colleen A. Mcnaney, Xiaomei Gu, Weiqi Chen, Ching Su, Michael D. Reily, Petia A. Shipkova, Jinping Gan, Yurong Lai, Punit Marathe and W. Griffith Humphreys
Drug Metabolism and Disposition February 2018, 46 (2) 178-188; DOI: https://doi.org/10.1124/dmd.117.077586
Hong Shen
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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David M. Nelson
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Regina V. Oliveira
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Yueping Zhang
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Colleen A. Mcnaney
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Xiaomei Gu
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Weiqi Chen
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Ching Su
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Michael D. Reily
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Petia A. Shipkova
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Jinping Gan
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Yurong Lai
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Punit Marathe
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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W. Griffith Humphreys
Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Article Information

vol. 46 no. 2 178-188
DOI 
https://doi.org/10.1124/dmd.117.077586
PubMed 
29162614

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 14, 2017
  • Accepted November 17, 2017
  • Published online January 19, 2018.

Article Versions

  • Earlier version (November 21, 2017 - 06:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hong Shen,
  2. David M. Nelson,
  3. Regina V. Oliveira,
  4. Yueping Zhang,
  5. Colleen A. Mcnaney,
  6. Xiaomei Gu,
  7. Weiqi Chen,
  8. Ching Su,
  9. Michael D. Reily,
  10. Petia A. Shipkova,
  11. Jinping Gan,
  12. Yurong Lai,
  13. Punit Marathe, and
  14. W. Griffith Humphreys
  1. Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
  1. Address correspondence to:
    Dr. Hong Shen, Department of Metabolism and Pharmacokinetics, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08543-4000. E-mail: hong.shen1{at}bms.com
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Drug Metabolism and Disposition: 46 (2)
Drug Metabolism and Disposition
Vol. 46, Issue 2
1 Feb 2018
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Research ArticleArticle

Identification of Functional Plasma Markers of OAT1 and OAT3

Hong Shen, David M. Nelson, Regina V. Oliveira, Yueping Zhang, Colleen A. Mcnaney, Xiaomei Gu, Weiqi Chen, Ching Su, Michael D. Reily, Petia A. Shipkova, Jinping Gan, Yurong Lai, Punit Marathe and W. Griffith Humphreys
Drug Metabolism and Disposition February 1, 2018, 46 (2) 178-188; DOI: https://doi.org/10.1124/dmd.117.077586

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Research ArticleArticle

Identification of Functional Plasma Markers of OAT1 and OAT3

Hong Shen, David M. Nelson, Regina V. Oliveira, Yueping Zhang, Colleen A. Mcnaney, Xiaomei Gu, Weiqi Chen, Ching Su, Michael D. Reily, Petia A. Shipkova, Jinping Gan, Yurong Lai, Punit Marathe and W. Griffith Humphreys
Drug Metabolism and Disposition February 1, 2018, 46 (2) 178-188; DOI: https://doi.org/10.1124/dmd.117.077586
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