Table of Contents

Articles

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  Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes

  J. Patrick Connick, James R. Reed and Wayne L. Backes

  Drug Metabolism and Disposition March 2018, 46 (3) 197-203; DOI: https://doi.org/10.1124/dmd.117.078642
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  Mechanism for Covalent Binding of MLN3126, an Oral Chemokine C-C Motif Receptor 9 Antagonist, to Serum Albumins

  Naohiro Narita, Akio Morohashi, Kimio Tohyama, Toshiyuki Takeuchi, Yoshihiko Tagawa, Takahiro Kondo and Satoru Asahi

  Drug Metabolism and Disposition March 2018, 46 (3) 204-213; DOI: https://doi.org/10.1124/dmd.117.078782
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  Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines

  Ikumi Washio, Takeo Nakanishi, Naoki Ishiguro, Norio Yamamura and Ikumi Tamai

  Drug Metabolism and Disposition March 2018, 46 (3) 214-222; DOI: https://doi.org/10.1124/dmd.117.078402
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  Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor

  Hugues de Boussac, Claire Gondeau, Philippe Briolotti, Cédric Duret, Fridolin Treindl, Michael Römer, Jean-Michel Fabre, Astrid Herrero, Jeanne Ramos, Patrick Maurel, Markus Templin, Sabine Gerbal-Chaloin and Martine Daujat-Chavanieu

  Drug Metabolism and Disposition March 2018, 46 (3) 223-236; DOI: https://doi.org/10.1124/dmd.117.078683
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  Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite—Resolution for Clinical Development

  Jim Zheng, Yan Xin, Jingyu Zhang, Raju Subramanian, Bernard P. Murray, J. Andrew Whitney, Matthew R. Warr, John Ling, Lisa Moorehead, Ellen Kwan, Jeffrey Hemenway, Bill J. Smith and Jeffrey A. Silverman

  Drug Metabolism and Disposition March 2018, 46 (3) 237-247; DOI: https://doi.org/10.1124/dmd.117.078899
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  REV-ERBα Regulates CYP7A1 Through Repression of Liver Receptor Homolog-1

  Tianpeng Zhang, Mengjing Zhao, Danyi Lu, Shuai Wang, Fangjun Yu, Lianxia Guo, Shijun Wen and Baojian Wu

  Drug Metabolism and Disposition March 2018, 46 (3) 248-258; DOI: https://doi.org/10.1124/dmd.117.078105
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  The Phenomenon of Albumin-Mediated Hepatic Uptake of Organic Anion Transport Polypeptide Substrates: Prediction of the In Vivo Uptake Clearance from the In Vitro Uptake by Isolated Hepatocytes Using a Facilitated-Dissociation Model

  Seiji Miyauchi, Masayuki Masuda, Soo-Jin Kim, Yuudai Tanaka, Kyeong-Ryoon Lee, Shouko Iwakado, Momoko Nemoto, Shotaro Sasaki, Kazumi Shimono, Yoshio Tanaka and Yuichi Sugiyama

  Drug Metabolism and Disposition March 2018, 46 (3) 259-267; DOI: https://doi.org/10.1124/dmd.117.077115
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  Importance of the Unstirred Water Layer and Hepatocyte Membrane Integrity In Vitro for Quantification of Intrinsic Metabolic Clearance

  Francesca L. Wood, J. Brian Houston and David Hallifax

  Drug Metabolism and Disposition March 2018, 46 (3) 268-278; DOI: https://doi.org/10.1124/dmd.117.078949
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  Derivation of a System-Independent K_i for P-glycoprotein Mediated Digoxin Transport from System-Dependent IC₅₀ Data

  Aqsaa Chaudhry, Git Chung, Adam Lynn, Akshata Yalvigi, Colin Brown, Harma Ellens, Michael O’Connor, Caroline Lee and Joe Bentz

  Drug Metabolism and Disposition March 2018, 46 (3) 279-290; DOI: https://doi.org/10.1124/dmd.117.075606
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  Bacterial Outer Membrane Vesicles from Dextran Sulfate Sodium–Induced Colitis Differentially Regulate Intestinal UDP-Glucuronosyltransferase 1A1 Partially Through Toll-Like Receptor 4/Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase Pathway

  Xue-Jiao Gao, Ting Li, Bin Wei, Zhi-Xiang Yan, Nan Hu, Yan-Juan Huang, Bei-Lei Han, Tai-Seng Wai, Wei Yang and Ru Yan

  Drug Metabolism and Disposition March 2018, 46 (3) 292-302; DOI: https://doi.org/10.1124/dmd.117.079046
• Open Access

  Late-occurring and Long-circulating Metabolites of GABA_Aα2,3 Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance

  Chungang Gu, Markus Artelsmair, Charles S. Elmore, Richard J. Lewis, Patty Davis, James E. Hall, Bruce T. Dembofsky, Greg Christoph, Mark A. Smith, Marc Chapdelaine and Maria Sunzel

  Drug Metabolism and Disposition March 2018, 46 (3) 303-315; DOI: https://doi.org/10.1124/dmd.117.078873
• Open Access

  Clinical Pharmacokinetics and the Impact of Genetic Polymorphism on a CYP2C19 Substrate, BMS-823778, in Healthy Subjects

  Jiachang Gong, Lars Hansen and Lisa Iacono

  Drug Metabolism and Disposition March 2018, 46 (3) 316-325; DOI: https://doi.org/10.1124/dmd.117.078824