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The Phenomenon of Albumin-Mediated Hepatic Uptake of Organic Anion Transport Polypeptide Substrates: Prediction of the In Vivo Uptake Clearance from the In Vitro Uptake by Isolated Hepatocytes Using a Facilitated-Dissociation Model

Seiji Miyauchi, Masayuki Masuda, Soo-Jin Kim, Yuudai Tanaka, Kyeong-Ryoon Lee, Shouko Iwakado, Momoko Nemoto, Shotaro Sasaki, Kazumi Shimono, Yoshio Tanaka and Yuichi Sugiyama
Drug Metabolism and Disposition March 2018, 46 (3) 259-267; DOI: https://doi.org/10.1124/dmd.117.077115

Article Information

vol. 46 no. 3 259-267
DOI 
https://doi.org/10.1124/dmd.117.077115
PubMed 
29298773
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 21, 2017
  • Accepted December 11, 2017
  • Published online February 2, 2018.

Article Versions

Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Seiji Miyauchi,
  2. Masayuki Masuda,
  3. Soo-Jin Kim1,
  4. Yuudai Tanaka,
  5. Kyeong-Ryoon Lee2,
  6. Shouko Iwakado,
  7. Momoko Nemoto,
  8. Shotaro Sasaki,
  9. Kazumi Shimono,
  10. Yoshio Tanaka, and
  11. Yuichi Sugiyama
  1. Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba, Japan (S.M., M.M., Y.T., S.I., M.N., S.S., K.S., Y.T.) and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Cluster for Industry Partnerships, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Japan (S.-J.K., K.-R.L., Y.S.)
  1. Address correspondence to:
    Dr. Yuichi Sugiyama, Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Cluster for Industry Partnerships, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. E-mail: ychi.sugiyama{at}riken.jp
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IVIVE for Albumin-Mediated Hepatic Uptake

Seiji Miyauchi, Masayuki Masuda, Soo-Jin Kim, Yuudai Tanaka, Kyeong-Ryoon Lee, Shouko Iwakado, Momoko Nemoto, Shotaro Sasaki, Kazumi Shimono, Yoshio Tanaka and Yuichi Sugiyama
Drug Metabolism and Disposition March 1, 2018, 46 (3) 259-267; DOI: https://doi.org/10.1124/dmd.117.077115
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