Article Figures & Data
Figures
Tables
Data Supplement
- Supplemental Figures -
Supplemental Figure 1 - Synthesis scheme and 15N HMBC spectrum of the M9 synthetic standard
Supplemental Figure 2 - LC-MS/MS CID spectra of human liver microsomal metabolite M9 vs. the synthetic M9 vs. human and preclinical animal plasma metabolites M9.
Supplemental Figure 3 - PDA UV spectra of AZD7325, the M9 metabolite and synthetic standard
Supplemental Figure 4 - LC-MS/MS chromatogram showing the formation of M10 and M42 by human liver microsomal incubation of the M9 synthetic standard
Supplemental Figure 5 - Confirmation of the human liver microsomal metabolite M42 to be identical to plasma metabolite M42 by LC-MS/MS CID high resolution spectra
Supplemental Figure 6 - Two convertible diastereomers of M42, presumably due to hindered rotation about the aryl-aryl bond
Supplemental Figure 7 - A tentative mechanism involving the formation of a 5-methyloxazole ring for M9 and a subsequent pathway leading to M42 was once considered.
Supplemental Figure 8 - On-column interconversion of carbinolamine metabolites M5 and M6 possibly involving an imine intermediate
Supplemental Figure 9 - Comparison in the exposure of the non-conjugate metabolites in the AUC pooled human plasma vs. the AUC pooled dog and rat plasma
- Supplemental Figures -