Drug Metabolism and Disposition: 46 (4)

April 01, 2018; Volume 46,Issue 4

Editorial

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Publishing in an ASPET Journal – What’s in It for You?
Mary Vore

Drug Metabolism and Disposition April 2018, 46 (4) 440-441; DOI: https://doi.org/10.1124/dmd.117.081034

Articles

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Regulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG Cells
Norman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M. Zanger, Linda Böhmert, Alfonso Lampen and Albert Braeuning

Drug Metabolism and Disposition April 2018, 46 (4) 326-335; DOI: https://doi.org/10.1124/dmd.117.078675
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Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In Vitro
Cen Xie, Xiaoxia Gao, Dongxue Sun, Youbo Zhang, Kristopher W. Krausz, Xuemei Qin and Frank J. Gonzalez

Drug Metabolism and Disposition April 2018, 46 (4) 336-345; DOI: https://doi.org/10.1124/dmd.117.079723
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A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects
Rui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li Di

Drug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
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A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects
Rui Li, Emi Kimoto, Mark Niosi, David A. Tess, Jian Lin, Larry M. Tremaine and Li Di

Drug Metabolism and Disposition April 2018, 46 (4) 357-366; DOI: https://doi.org/10.1124/dmd.117.078808
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Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D₃-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans
Timothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. Thummel

Drug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
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CYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species Toxicity
Eric A. Evangelista, Rozenn N. Lemaitre, Nona Sotoodehnia, Sina A. Gharib and Rheem A. Totah

Drug Metabolism and Disposition April 2018, 46 (4) 380-386; DOI: https://doi.org/10.1124/dmd.117.078840
Open Access
Direct Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates
Frederik Weiß, Helen S. Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M. Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O. Joos and Oliver Poetz

Drug Metabolism and Disposition April 2018, 46 (4) 387-396; DOI: https://doi.org/10.1124/dmd.117.078626
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Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro
Guncha Taneja, Chun Chu, Paramahamsa Maturu, Bhagavatula Moorthy and Romi Ghose

Drug Metabolism and Disposition April 2018, 46 (4) 397-404; DOI: https://doi.org/10.1124/dmd.117.079160
Open Access
Simultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss Approach
James Harrison, Tom De Bruyn, Adam S. Darwich and J. Brian Houston

Drug Metabolism and Disposition April 2018, 46 (4) 405-414; DOI: https://doi.org/10.1124/dmd.117.079590
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Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines
Keith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li Di

Drug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
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Maternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant Rats
Xia Li, Xiaojing Yang, E Xiang, Jinyuan Luo, Shuaikai Qiu, Yan Fang, Li Zhang, Yu Guo, Jiang Zheng and Hui Wang

Drug Metabolism and Disposition April 2018, 46 (4) 422-428; DOI: https://doi.org/10.1124/dmd.117.079186
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Metabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis
Hong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. Lee

Drug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
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Identification of Ketene-Reactive Intermediate of Erlotinib Possibly Responsible for Inactivation of P450 Enzymes
Huimin Zhao, Siyuan Li, Zixin Yang, Ying Peng, Xiaohui Chen and Jiang Zheng

Drug Metabolism and Disposition April 2018, 46 (4) 442-450; DOI: https://doi.org/10.1124/dmd.117.079327
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LC-MS Differential Analysis for Fast and Sensitive Determination of Biotransformation of Therapeutic Proteins
Ming Yao, Bingming Chen, Weiping Zhao, John T. Mehl, Lingjun Li and Mingshe Zhu

Drug Metabolism and Disposition April 2018, 46 (4) 451-457; DOI: https://doi.org/10.1124/dmd.117.077792
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Mathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging Properties
J. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker Fischer

Drug Metabolism and Disposition April 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
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Identification of Galeterone and Abiraterone as Inhibitors of Dehydroepiandrosterone Sulfonation Catalyzed by Human Hepatic Cytosol, SULT2A1, SULT2B1b, and SULT1E1
Caleb Keng Yan Yip, Sumit Bansal, Siew Ying Wong and Aik Jiang Lau

Drug Metabolism and Disposition April 2018, 46 (4) 470-482; DOI: https://doi.org/10.1124/dmd.117.078980

Errata

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Correction to “A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects”
Drug Metabolism and Disposition April 2018, 46 (4) 483; DOI: https://doi.org/10.1124/dmd.117.078790err
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Correction to “A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects”
Drug Metabolism and Disposition April 2018, 46 (4) 484; DOI: https://doi.org/10.1124/dmd.117.078808err

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