Research ArticleArticle
Metabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis
Hong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. Lee
Drug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
Hong Liu
Bioanalysis and Biotransformation (H.L., M.J.M., J.S., A.J.L.), DMPK and Translational Modeling (D.M.S., X.L.), Process Chemistry (A.D.R.), Discovery Chemistry and Technology (M.R.S.), and Clinical Pharmacology and Pharmacometrics (A.A.O.), Research and Development, AbbVie, North Chicago, Illinois
David M. Stresser
Bioanalysis and Biotransformation (H.L., M.J.M., J.S., A.J.L.), DMPK and Translational Modeling (D.M.S., X.L.), Process Chemistry (A.D.R.), Discovery Chemistry and Technology (M.R.S.), and Clinical Pharmacology and Pharmacometrics (A.A.O.), Research and Development, AbbVie, North Chicago, Illinois
Melissa J. Michmerhuizen
Bioanalysis and Biotransformation (H.L., M.J.M., J.S., A.J.L.), DMPK and Translational Modeling (D.M.S., X.L.), Process Chemistry (A.D.R.), Discovery Chemistry and Technology (M.R.S.), and Clinical Pharmacology and Pharmacometrics (A.A.O.), Research and Development, AbbVie, North Chicago, Illinois
Xiaofeng Li
Bioanalysis and Biotransformation (H.L., M.J.M., J.S., A.J.L.), DMPK and Translational Modeling (D.M.S., X.L.), Process Chemistry (A.D.R.), Discovery Chemistry and Technology (M.R.S.), and Clinical Pharmacology and Pharmacometrics (A.A.O.), Research and Development, AbbVie, North Chicago, Illinois
Ahmed A. Othman
Bioanalysis and Biotransformation (H.L., M.J.M., J.S., A.J.L.), DMPK and Translational Modeling (D.M.S., X.L.), Process Chemistry (A.D.R.), Discovery Chemistry and Technology (M.R.S.), and Clinical Pharmacology and Pharmacometrics (A.A.O.), Research and Development, AbbVie, North Chicago, Illinois
Aimee D. Reed
Bioanalysis and Biotransformation (H.L., M.J.M., J.S., A.J.L.), DMPK and Translational Modeling (D.M.S., X.L.), Process Chemistry (A.D.R.), Discovery Chemistry and Technology (M.R.S.), and Clinical Pharmacology and Pharmacometrics (A.A.O.), Research and Development, AbbVie, North Chicago, Illinois
Michael R. Schrimpf
Bioanalysis and Biotransformation (H.L., M.J.M., J.S., A.J.L.), DMPK and Translational Modeling (D.M.S., X.L.), Process Chemistry (A.D.R.), Discovery Chemistry and Technology (M.R.S.), and Clinical Pharmacology and Pharmacometrics (A.A.O.), Research and Development, AbbVie, North Chicago, Illinois
Jens Sydor
Bioanalysis and Biotransformation (H.L., M.J.M., J.S., A.J.L.), DMPK and Translational Modeling (D.M.S., X.L.), Process Chemistry (A.D.R.), Discovery Chemistry and Technology (M.R.S.), and Clinical Pharmacology and Pharmacometrics (A.A.O.), Research and Development, AbbVie, North Chicago, Illinois
Anthony J. Lee
Bioanalysis and Biotransformation (H.L., M.J.M., J.S., A.J.L.), DMPK and Translational Modeling (D.M.S., X.L.), Process Chemistry (A.D.R.), Discovery Chemistry and Technology (M.R.S.), and Clinical Pharmacology and Pharmacometrics (A.A.O.), Research and Development, AbbVie, North Chicago, Illinois
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Research ArticleArticle
Metabolism and Disposition of ABT-126 in Humans
Hong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. Lee
Drug Metabolism and Disposition April 1, 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
Research ArticleArticle
Metabolism and Disposition of ABT-126 in Humans
Hong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. Lee
Drug Metabolism and Disposition April 1, 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
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