Research ArticleArticle
Identification of Ketene-Reactive Intermediate of Erlotinib Possibly Responsible for Inactivation of P450 Enzymes
Huimin Zhao, Siyuan Li, Zixin Yang, Ying Peng, Xiaohui Chen and Jiang Zheng
Drug Metabolism and Disposition April 2018, 46 (4) 442-450; DOI: https://doi.org/10.1124/dmd.117.079327
Huimin Zhao
School of Pharmacy (H.Z., X.C.) and Wuya College of Innovation (S.L., Z.Y., Y.P., J.Z.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People’s Republic of China; and State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China (J.Z.)
Siyuan Li
School of Pharmacy (H.Z., X.C.) and Wuya College of Innovation (S.L., Z.Y., Y.P., J.Z.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People’s Republic of China; and State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China (J.Z.)
Zixin Yang
School of Pharmacy (H.Z., X.C.) and Wuya College of Innovation (S.L., Z.Y., Y.P., J.Z.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People’s Republic of China; and State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China (J.Z.)
Ying Peng
School of Pharmacy (H.Z., X.C.) and Wuya College of Innovation (S.L., Z.Y., Y.P., J.Z.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People’s Republic of China; and State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China (J.Z.)
Xiaohui Chen
School of Pharmacy (H.Z., X.C.) and Wuya College of Innovation (S.L., Z.Y., Y.P., J.Z.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People’s Republic of China; and State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China (J.Z.)
Jiang Zheng
School of Pharmacy (H.Z., X.C.) and Wuya College of Innovation (S.L., Z.Y., Y.P., J.Z.), Shenyang Pharmaceutical University, Shenyang, Liaoning, People’s Republic of China; and State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China (J.Z.)
Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleArticle
Bioactivation of Erlotinib to Ketene Intermediate
Huimin Zhao, Siyuan Li, Zixin Yang, Ying Peng, Xiaohui Chen and Jiang Zheng
Drug Metabolism and Disposition April 1, 2018, 46 (4) 442-450; DOI: https://doi.org/10.1124/dmd.117.079327
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement