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Research ArticleArticle

A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multidrug-Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport

Xiaojie Zang, Guangji Wang, Qingyun Cai, Xiao Zheng, Jingwei Zhang, Qianying Chen, Baojin Wu, Xiong Zhu, Haiping Hao and Fang Zhou
Drug Metabolism and Disposition May 2018, 46 (5) 542-551; DOI: https://doi.org/10.1124/dmd.117.079442
Xiaojie Zang
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
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Guangji Wang
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
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Qingyun Cai
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
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Xiao Zheng
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
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Jingwei Zhang
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
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Qianying Chen
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
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Baojin Wu
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
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Xiong Zhu
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
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Haiping Hao
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
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Fang Zhou
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
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Article Information

vol. 46 no. 5 542-551
DOI 
https://doi.org/10.1124/dmd.117.079442
PubMed 
29523600

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 10, 2017
  • Accepted February 22, 2018
  • Published online April 4, 2018.

Article Versions

  • Earlier version (March 9, 2018 - 08:45).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xiaojie Zang1,
  2. Guangji Wang1,
  3. Qingyun Cai,
  4. Xiao Zheng,
  5. Jingwei Zhang,
  6. Qianying Chen,
  7. Baojin Wu,
  8. Xiong Zhu,
  9. Haiping Hao, and
  10. Fang Zhou
  1. Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines (X.Za., G.W., Q.Ca., X.Zhe., J.Z., Q.Ch., H.H., F.Z.), and Medical and Chemical Institute (B.W., X.Zhu.), China Pharmaceutical University, Nanjing, China
  1. Address correspondence to:
    Fang Zhou, Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. E-mail: zf1113{at}163.com; or Haiping Hao, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. E-mail: hhp_770505{at}hotmail.com
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Drug Metabolism and Disposition: 46 (5)
Drug Metabolism and Disposition
Vol. 46, Issue 5
1 May 2018
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Research ArticleArticle

A Promising Microtubule Inhibitor Overcomes MDR

Xiaojie Zang, Guangji Wang, Qingyun Cai, Xiao Zheng, Jingwei Zhang, Qianying Chen, Baojin Wu, Xiong Zhu, Haiping Hao and Fang Zhou
Drug Metabolism and Disposition May 1, 2018, 46 (5) 542-551; DOI: https://doi.org/10.1124/dmd.117.079442

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Research ArticleArticle

A Promising Microtubule Inhibitor Overcomes MDR

Xiaojie Zang, Guangji Wang, Qingyun Cai, Xiao Zheng, Jingwei Zhang, Qianying Chen, Baojin Wu, Xiong Zhu, Haiping Hao and Fang Zhou
Drug Metabolism and Disposition May 1, 2018, 46 (5) 542-551; DOI: https://doi.org/10.1124/dmd.117.079442
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