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Rapid CommunicationSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction—Short Communication

Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation

Anna Vildhede, Chuong Nguyen, Brian K. Erickson, Ryan C. Kunz, Richard Jones, Emi Kimoto, Francis Bourbonais, A. David Rodrigues and Manthena V.S. Varma
Drug Metabolism and Disposition May 2018, 46 (5) 692-696; DOI: https://doi.org/10.1124/dmd.117.079285

Article Information

vol. 46 no. 5 692-696
DOI 
https://doi.org/10.1124/dmd.117.079285
PubMed 
29439128
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 2, 2017
  • Accepted February 8, 2018
  • Published online April 10, 2018.

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Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anna Vildhede,
  2. Chuong Nguyen,
  3. Brian K. Erickson,
  4. Ryan C. Kunz,
  5. Richard Jones,
  6. Emi Kimoto,
  7. Francis Bourbonais,
  8. A. David Rodrigues, and
  9. Manthena V.S. Varma
  1. Pharmacokinetics, Dynamics and Metabolism (A.V., E.K., A.D.R., M.V.S.V.) and Discovery Sciences (C.N., F.B.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut; IQ Proteomics, Cambridge, Massachusetts (B.K.E., R.C.K.); and MS Bioworks, Ann Arbor, Michigan (R.J.)
  1. Address correspondence to:
    Dr. Manthena V. Varma, Pharmacokinetics, Dynamics, and Metabolism, MS 8220-2451, Pfizer Global Research and Development, Pfizer Inc., Groton, CT 06340. E-mail: manthena.v.varma{at}pfizer.com
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Rapid CommunicationSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction—Short Communication

Targeted versus Global Proteomic Quantification of Transporters

Anna Vildhede, Chuong Nguyen, Brian K. Erickson, Ryan C. Kunz, Richard Jones, Emi Kimoto, Francis Bourbonais, A. David Rodrigues and Manthena V.S. Varma
Drug Metabolism and Disposition May 1, 2018, 46 (5) 692-696; DOI: https://doi.org/10.1124/dmd.117.079285
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