Rapid CommunicationSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction—Short Communication
Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation
Anna Vildhede, Chuong Nguyen, Brian K. Erickson, Ryan C. Kunz, Richard Jones, Emi Kimoto, Francis Bourbonais, A. David Rodrigues and Manthena V.S. Varma
Drug Metabolism and Disposition May 2018, 46 (5) 692-696; DOI: https://doi.org/10.1124/dmd.117.079285
Anna Vildhede
Pharmacokinetics, Dynamics and Metabolism (A.V., E.K., A.D.R., M.V.S.V.) and Discovery Sciences (C.N., F.B.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut; IQ Proteomics, Cambridge, Massachusetts (B.K.E., R.C.K.); and MS Bioworks, Ann Arbor, Michigan (R.J.)
Chuong Nguyen
Pharmacokinetics, Dynamics and Metabolism (A.V., E.K., A.D.R., M.V.S.V.) and Discovery Sciences (C.N., F.B.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut; IQ Proteomics, Cambridge, Massachusetts (B.K.E., R.C.K.); and MS Bioworks, Ann Arbor, Michigan (R.J.)
Brian K. Erickson
Pharmacokinetics, Dynamics and Metabolism (A.V., E.K., A.D.R., M.V.S.V.) and Discovery Sciences (C.N., F.B.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut; IQ Proteomics, Cambridge, Massachusetts (B.K.E., R.C.K.); and MS Bioworks, Ann Arbor, Michigan (R.J.)
Ryan C. Kunz
Pharmacokinetics, Dynamics and Metabolism (A.V., E.K., A.D.R., M.V.S.V.) and Discovery Sciences (C.N., F.B.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut; IQ Proteomics, Cambridge, Massachusetts (B.K.E., R.C.K.); and MS Bioworks, Ann Arbor, Michigan (R.J.)
Richard Jones
Pharmacokinetics, Dynamics and Metabolism (A.V., E.K., A.D.R., M.V.S.V.) and Discovery Sciences (C.N., F.B.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut; IQ Proteomics, Cambridge, Massachusetts (B.K.E., R.C.K.); and MS Bioworks, Ann Arbor, Michigan (R.J.)
Emi Kimoto
Pharmacokinetics, Dynamics and Metabolism (A.V., E.K., A.D.R., M.V.S.V.) and Discovery Sciences (C.N., F.B.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut; IQ Proteomics, Cambridge, Massachusetts (B.K.E., R.C.K.); and MS Bioworks, Ann Arbor, Michigan (R.J.)
Francis Bourbonais
Pharmacokinetics, Dynamics and Metabolism (A.V., E.K., A.D.R., M.V.S.V.) and Discovery Sciences (C.N., F.B.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut; IQ Proteomics, Cambridge, Massachusetts (B.K.E., R.C.K.); and MS Bioworks, Ann Arbor, Michigan (R.J.)
A. David Rodrigues
Pharmacokinetics, Dynamics and Metabolism (A.V., E.K., A.D.R., M.V.S.V.) and Discovery Sciences (C.N., F.B.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut; IQ Proteomics, Cambridge, Massachusetts (B.K.E., R.C.K.); and MS Bioworks, Ann Arbor, Michigan (R.J.)
Manthena V.S. Varma
Pharmacokinetics, Dynamics and Metabolism (A.V., E.K., A.D.R., M.V.S.V.) and Discovery Sciences (C.N., F.B.), Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut; IQ Proteomics, Cambridge, Massachusetts (B.K.E., R.C.K.); and MS Bioworks, Ann Arbor, Michigan (R.J.)
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Rapid CommunicationSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction—Short Communication
Targeted versus Global Proteomic Quantification of Transporters
Anna Vildhede, Chuong Nguyen, Brian K. Erickson, Ryan C. Kunz, Richard Jones, Emi Kimoto, Francis Bourbonais, A. David Rodrigues and Manthena V.S. Varma
Drug Metabolism and Disposition May 1, 2018, 46 (5) 692-696; DOI: https://doi.org/10.1124/dmd.117.079285
Rapid CommunicationSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction—Short Communication
Targeted versus Global Proteomic Quantification of Transporters
Anna Vildhede, Chuong Nguyen, Brian K. Erickson, Ryan C. Kunz, Richard Jones, Emi Kimoto, Francis Bourbonais, A. David Rodrigues and Manthena V.S. Varma
Drug Metabolism and Disposition May 1, 2018, 46 (5) 692-696; DOI: https://doi.org/10.1124/dmd.117.079285
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