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Drug Metabolism & Disposition

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Table of Contents

June 01, 2018; Volume 46,Issue 6

Commentary

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    Data Generated by Quantitative Liquid Chromatography-Mass Spectrometry Proteomics Are Only the Start and Not the Endpoint: Optimization of Quantitative Concatemer-Based Measurement of Hepatic Uridine-5′-Diphosphate–Glucuronosyltransferase Enzymes with Reference to Catalytic Activity
    Brahim Achour, Alyssa Dantonio, Mark Niosi, Jonathan J. Novak, Zubida M. Al-Majdoub, Theunis C. Goosen, Amin Rostami-Hodjegan and Jill Barber
    Drug Metabolism and Disposition June 2018, 46 (6) 805-812; DOI: https://doi.org/10.1124/dmd.117.079475
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    Safety Assessment of Acyl Glucuronides—A Simplified Paradigm
    Dennis A. Smith, Timothy Hammond and Thomas A. Baillie
    Drug Metabolism and Disposition June 2018, 46 (6) 908-912; DOI: https://doi.org/10.1124/dmd.118.080515

Minireviews

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    Risk of Clinically Relevant Pharmacokinetic-Based Drug-Drug Interactions with Drugs Approved by the U.S. Food and Drug Administration Between 2013 and 2016
    Jingjing Yu, Zhu Zhou, Jessica Tay-Sontheimer, René H. Levy and Isabelle Ragueneau-Majlessi
    Drug Metabolism and Disposition June 2018, 46 (6) 835-845; DOI: https://doi.org/10.1124/dmd.117.078691
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    A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance
    Simone Schadt, Bojan Bister, Swapan K. Chowdhury, Christoph Funk, Cornelis E. C. A. Hop, W. Griffith Humphreys, Fumihiko Igarashi, Alexander D. James, Mark Kagan, S. Cyrus Khojasteh, Angus N. R. Nedderman, Chandra Prakash, Frank Runge, Holger Scheible, Douglas K. Spracklin, Piet Swart, Susanna Tse, Josh Yuan and R. Scott Obach
    Drug Metabolism and Disposition June 2018, 46 (6) 865-878; DOI: https://doi.org/10.1124/dmd.117.079848

Articles

  • <em>N</em>-Methylation of BI 187004 by Thiol <em>S</em>-Methyltransferase
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    N-Methylation of BI 187004 by Thiol S-Methyltransferase
    Hlaing H. Maw, Xingzhong Zeng, Scot Campbell, Mitchell E. Taub and Aaron M. Teitelbaum
    Drug Metabolism and Disposition June 2018, 46 (6) 770-778; DOI: https://doi.org/10.1124/dmd.117.079764
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    Substrate Selectivity Check of the Ergothioneine Transporter
    Julia Tschirka, Madlen Kreisor, Janina Betz and Dirk Gründemann
    Drug Metabolism and Disposition June 2018, 46 (6) 779-785; DOI: https://doi.org/10.1124/dmd.118.080440
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    Activation of 5-HT1A Receptors in the Hypothalamic Paraventricular Nuclei Negatively Regulates Cytochrome P450 Expression and Activity in Rat Liver
    Ewa Bromek, Marta Rysz, Anna Haduch, Jacek Wójcikowski and Władysława A. Daniel
    Drug Metabolism and Disposition June 2018, 46 (6) 786-793; DOI: https://doi.org/10.1124/dmd.117.079632
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    Structural Studies of Multidrug Resistance Protein 1 Using “Almost” Cysless Template
    Daria N. Trofimova and Roger G. Deeley
    Drug Metabolism and Disposition June 2018, 46 (6) 794-804; DOI: https://doi.org/10.1124/dmd.117.078709
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    Formation of Both Heme and Apoprotein Adducts Contributes to the Mechanism-Based Inactivation of Human CYP2J2 by 17α-Ethynylestradiol
    Hsia-lien Lin, Haoming Zhang and Paul F. Hollenberg
    Drug Metabolism and Disposition June 2018, 46 (6) 813-822; DOI: https://doi.org/10.1124/dmd.118.080903
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    Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management
    Nating Zhang, Chen Cheng, Olajide E. Olaleye, Yan Sun, Li Li, Yühong Huang, Feifei Du, Junling Yang, Fengqing Wang, Yanhong Shi, Fang Xu, Yanfen Li, Qi Wen, Naixia Zhang and Chuan Li
    Drug Metabolism and Disposition June 2018, 46 (6) 823-834; DOI: https://doi.org/10.1124/dmd.117.079673
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    Refinement of In Vitro Methods for Identification of Aldehyde Oxidase Substrates Reveals Metabolites of Kinase Inhibitors
    Ryan A. Dick
    Drug Metabolism and Disposition June 2018, 46 (6) 846-859; DOI: https://doi.org/10.1124/dmd.118.080960
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    New Pioglitazone Metabolites and Absence of Opened-Ring Metabolites in New N-Substituted Thiazolidinedione
    Michel Leandro Campos, Letícia Bonancio Cerqueira, Bruna Cristina Ulian Silva, Taísa Busaranho Franchin, Marina Rocha Galdino-Pitta, Ivan Rocha Pitta, Rosângela Gonçalves Peccinini and Roberto Pontarolo
    Drug Metabolism and Disposition June 2018, 46 (6) 879-887; DOI: https://doi.org/10.1124/dmd.117.079012
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    Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex
    Deepak Kumar Bhatt, Abdul Basit, Haeyoung Zhang, Andrea Gaedigk, Seung-been Lee, Katrina G. Claw, Aanchal Mehrotra, Amarjit Singh Chaudhry, Robin E. Pearce, Roger Gaedigk, Ulrich Broeckel, Timothy A. Thornton, Deborah A. Nickerson, Erin G. Schuetz, John K. Amory, J. Steven Leeder and Bhagwat Prasad
    Drug Metabolism and Disposition June 2018, 46 (6) 888-896; DOI: https://doi.org/10.1124/dmd.118.080952
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    Predicting Antitumor Effect of Deoxypodophyllotoxin in NCI-H460 Tumor-Bearing Mice on the Basis of In Vitro Pharmacodynamics and a Physiologically Based Pharmacokinetic-Pharmacodynamic Model
    Yang Chen, Kaijing Zhao, Fei Liu, Ying Li, Zeyu Zhong, Shijin Hong, Xiaodong Liu and Li Liu
    Drug Metabolism and Disposition June 2018, 46 (6) 897-907; DOI: https://doi.org/10.1124/dmd.117.079830
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    Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo Models
    Gabriela Dovrtelova, Ondrej Zendulka, Kristyna Noskova, Jan Jurica, Ondrej Pes, Jan Dusek, Alejandro Carazo, Iveta Zapletalova, Natasa Hlavacova and Petr Pavek
    Drug Metabolism and Disposition June 2018, 46 (6) 913-923; DOI: https://doi.org/10.1124/dmd.117.079582

Short Communication

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    Sulfotransferase 4A1 Increases Its Expression in Mouse Neurons as They Mature
    Takuyu Hashiguchi, Sawako Shindo, Shih-Heng Chen, Jau-Shyong Hong and Masahiko Negishi
    Drug Metabolism and Disposition June 2018, 46 (6) 860-864; DOI: https://doi.org/10.1124/dmd.118.080838
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Drug Metabolism and Disposition: 46 (6)
Drug Metabolism and Disposition
Vol. 46, Issue 6
1 Jun 2018
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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