Research ArticleMinireviews
A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance
Simone Schadt, Bojan Bister, Swapan K. Chowdhury, Christoph Funk, Cornelis E. C. A. Hop, W. Griffith Humphreys, Fumihiko Igarashi, Alexander D. James, Mark Kagan, S. Cyrus Khojasteh, Angus N. R. Nedderman, Chandra Prakash, Frank Runge, Holger Scheible, Douglas K. Spracklin, Piet Swart, Susanna Tse, Josh Yuan and R. Scott Obach
Drug Metabolism and Disposition June 2018, 46 (6) 865-878; DOI: https://doi.org/10.1124/dmd.117.079848
Simone Schadt
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Bojan Bister
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Swapan K. Chowdhury
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Christoph Funk
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Cornelis E. C. A. Hop
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
W. Griffith Humphreys
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Fumihiko Igarashi
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Alexander D. James
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Mark Kagan
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
S. Cyrus Khojasteh
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Angus N. R. Nedderman
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Chandra Prakash
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Frank Runge
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Holger Scheible
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Douglas K. Spracklin
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Piet Swart
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Susanna Tse
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Josh Yuan
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
R. Scott Obach
Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
Article Information
vol. 46 no. 6 865-878
PubMed
Print ISSN
Online ISSN
History
- Received December 6, 2017
- Accepted February 21, 2018
- Published online April 30, 2018.
Article Versions
- Earlier version (February 27, 2018 - 06:05).
- You are viewing the most recent version of this article.
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Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics
Author Information
- Simone Schadt,
- Bojan Bister,
- Swapan K. Chowdhury,
- Christoph Funk,
- Cornelis E. C. A. Hop,
- W. Griffith Humphreys,
- Fumihiko Igarashi,
- Alexander D. James,
- Mark Kagan,
- S. Cyrus Khojasteh,
- Angus N. R. Nedderman,
- Chandra Prakash,
- Frank Runge,
- Holger Scheible,
- Douglas K. Spracklin,
- Piet Swart,
- Susanna Tse,
- Josh Yuan, and
- R. Scott Obach
- Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (S.S., C.F.); Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riß, Germany (B.B., F.R.); Drug Metabolism and Pharmacokinetics Department, Takeda Pharmaceutical International Co., Cambridge, Massachusetts (S.K.C., J.Y.); Genentech, Inc., Drug Metabolism and Pharmacokinetics, South San Francisco, California (C.E.C.A.H., S.C.K.); Bristol-Myers Squibb Pharmaceutical Co., Princeton, New Jersey (W.G.H.); Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan (F.I.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J.); PK Sciences (ADME), Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, New Jersey (M.K.); Unilabs York Bioanalytical Solutions, Discovery Park House, Discovery Park, Sandwich, Kent, United Kingdom (A.N.R.N); Drug Metabolism, Pharmacokinetics and Clinical Pharmacology, Agios, Cambridge, Massachusetts (C.P.); Merck Biopharma, Quantitative Pharmacology and Drug Disposition, NCE Drug Disposition, Darmstadt, Germany (H.S., P.S.); and Pfizer, Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (D.K.S., S.T., R.S.O.)
- Address correspondence to:
Simone Schadt, Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacher Strasse 124, 4070 Basel, Switzerland. E-mail: simone.schadt{at}roche.com
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Research ArticleMinireviews
A Decade in the MIST
Simone Schadt, Bojan Bister, Swapan K. Chowdhury, Christoph Funk, Cornelis E. C. A. Hop, W. Griffith Humphreys, Fumihiko Igarashi, Alexander D. James, Mark Kagan, S. Cyrus Khojasteh, Angus N. R. Nedderman, Chandra Prakash, Frank Runge, Holger Scheible, Douglas K. Spracklin, Piet Swart, Susanna Tse, Josh Yuan and R. Scott Obach
Drug Metabolism and Disposition June 1, 2018, 46 (6) 865-878; DOI: https://doi.org/10.1124/dmd.117.079848
Research ArticleMinireviews
A Decade in the MIST
Simone Schadt, Bojan Bister, Swapan K. Chowdhury, Christoph Funk, Cornelis E. C. A. Hop, W. Griffith Humphreys, Fumihiko Igarashi, Alexander D. James, Mark Kagan, S. Cyrus Khojasteh, Angus N. R. Nedderman, Chandra Prakash, Frank Runge, Holger Scheible, Douglas K. Spracklin, Piet Swart, Susanna Tse, Josh Yuan and R. Scott Obach
Drug Metabolism and Disposition June 1, 2018, 46 (6) 865-878; DOI: https://doi.org/10.1124/dmd.117.079848
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