Table of Contents

Articles

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  Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling

  Yoshiaki Yao, Kota Toshimoto, Soo-Jin Kim, Takashi Yoshikado and Yuichi Sugiyama

  Drug Metabolism and Disposition July 2018, 46 (7) 924-933; DOI: https://doi.org/10.1124/dmd.117.079210
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  Metabolism of a 5HT₆ Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction

  Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery

  Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457
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  Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study

  Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat

  Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523
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  Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling

  Pallabi Mitra, Samantha Weinheimer, Meeghan Michalewicz and Mitchell E. Taub

  Drug Metabolism and Disposition July 2018, 46 (7) 953-963; DOI: https://doi.org/10.1124/dmd.118.080614
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  Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter

  Danyi Lu, Dong Dong, Qian Xie, Zhijie Li and Baojian Wu

  Drug Metabolism and Disposition July 2018, 46 (7) 970-979; DOI: https://doi.org/10.1124/dmd.118.080804
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  Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics

  Fangjun Yu, Tianpeng Zhang, Lianxia Guo and Baojian Wu

  Drug Metabolism and Disposition July 2018, 46 (7) 980-988; DOI: https://doi.org/10.1124/dmd.118.080895
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  Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

  Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston

  Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315
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  Metabolism and Disposition of Siponimod, a Novel Selective S1P₁/S1P₅ Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism

  Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin

  Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574
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  Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice

  Samit Ganguly, John C. Panetta, Jessica K. Roberts and Erin G. Schuetz

  Drug Metabolism and Disposition July 2018, 46 (7) 1014-1022; DOI: https://doi.org/10.1124/dmd.117.078360
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  11β-Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism

  Xin Yang, Wenyi Hua, Sangwoo Ryu, Phillip Yates, Cheng Chang, Hui Zhang and Li Di

  Drug Metabolism and Disposition July 2018, 46 (7) 1023-1029; DOI: https://doi.org/10.1124/dmd.118.081083
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  Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis

  Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez

  Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176