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Index by author

July 01, 2018; Volume 46,Issue 7

A

  1. Adam-Stitah, Sylvie

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

B

  1. Bhatt, Deepak Kumar

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

  2. Bi, Yi-an

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

  3. Bisson, William H.

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

  4. Borell, Hubert

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

C

  1. Camenisch, Gian

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

  2. Cantrill, Carina

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

  3. Chang, Cheng

    1. 11β-Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism
      Xin Yang, Wenyi Hua, Sangwoo Ryu, Phillip Yates, Cheng Chang, Hui Zhang and Li Di
      Drug Metabolism and Disposition July 2018, 46 (7) 1023-1029; DOI: https://doi.org/10.1124/dmd.118.081083

  4. Chapa, Revathi

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

  5. Chu, Xiaoyan

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

  6. Comery, Thomas A.

    1. Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction
      Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
      Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457

D

  1. De Bruyn, Tom

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

  2. Deshmukh, Gauri

    1. Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats
      Matthew R. Durk, Gauri Deshmukh, Nicole Valle, Xiao Ding, Bianca M. Liederer and Xingrong Liu
      Drug Metabolism and Disposition July 2018, 46 (7) 964-969; DOI: https://doi.org/10.1124/dmd.118.080697

  3. Di, Li

    1. 11β-Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism
      Xin Yang, Wenyi Hua, Sangwoo Ryu, Phillip Yates, Cheng Chang, Hui Zhang and Li Di
      Drug Metabolism and Disposition July 2018, 46 (7) 1023-1029; DOI: https://doi.org/10.1124/dmd.118.081083

  4. Ding, Xiao

    1. Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats
      Matthew R. Durk, Gauri Deshmukh, Nicole Valle, Xiao Ding, Bianca M. Liederer and Xingrong Liu
      Drug Metabolism and Disposition July 2018, 46 (7) 964-969; DOI: https://doi.org/10.1124/dmd.118.080697

  5. Dong, Dong

    1. Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter
      Danyi Lu, Dong Dong, Qian Xie, Zhijie Li and Baojian Wu
      Drug Metabolism and Disposition July 2018, 46 (7) 970-979; DOI: https://doi.org/10.1124/dmd.118.080804

  6. Doran, Angela

    1. Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction
      Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
      Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457

  7. Durk, Matthew R.

    1. Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats
      Matthew R. Durk, Gauri Deshmukh, Nicole Valle, Xiao Ding, Bianca M. Liederer and Xingrong Liu
      Drug Metabolism and Disposition July 2018, 46 (7) 964-969; DOI: https://doi.org/10.1124/dmd.118.080697

G

  1. Galetin, Aleksandra

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

  2. Ganguly, Samit

    1. Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice
      Samit Ganguly, John C. Panetta, Jessica K. Roberts and Erin G. Schuetz
      Drug Metabolism and Disposition July 2018, 46 (7) 1014-1022; DOI: https://doi.org/10.1124/dmd.117.078360

  3. Gao, Hongying

    1. Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction
      Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
      Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457

  4. Gardin, Anne

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

  5. Glaenzel, Ulrike

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

  6. Gonzalez, Frank J.

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

  7. González-Peréz, Vanessa

    1. Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach
      Emily J. Johnson, Vanessa González-Peréz, Dan-Dan Tian, Yvonne S. Lin, Jashvant D. Unadkat, Allan E. Rettie, Danny D. Shen, Jeannine S. McCune and Mary F. Paine
      Drug Metabolism and Disposition July 2018, 46 (7) 1046-1052; DOI: https://doi.org/10.1124/dmd.118.081273

  8. Guo, Lianxia

    1. Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics
      Fangjun Yu, Tianpeng Zhang, Lianxia Guo and Baojian Wu
      Drug Metabolism and Disposition July 2018, 46 (7) 980-988; DOI: https://doi.org/10.1124/dmd.118.080895

H

  1. Hop, Cornelis E. C. A.

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

  2. Houston, J. Brian

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

  3. Hua, Wenyi

    1. 11β-Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism
      Xin Yang, Wenyi Hua, Sangwoo Ryu, Phillip Yates, Cheng Chang, Hui Zhang and Li Di
      Drug Metabolism and Disposition July 2018, 46 (7) 1023-1029; DOI: https://doi.org/10.1124/dmd.118.081083

  4. Humphreys, William G.

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

J

  1. James, Alexander D.

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

  2. Jin, Yi

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

  3. Johnson, Emily J.

    1. Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach
      Emily J. Johnson, Vanessa González-Peréz, Dan-Dan Tian, Yvonne S. Lin, Jashvant D. Unadkat, Allan E. Rettie, Danny D. Shen, Jeannine S. McCune and Mary F. Paine
      Drug Metabolism and Disposition July 2018, 46 (7) 1046-1052; DOI: https://doi.org/10.1124/dmd.118.081273

  4. Johnson, Katherine

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

K

  1. Kim, Soo-Jin

    1. Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling
      Yoshiaki Yao, Kota Toshimoto, Soo-Jin Kim, Takashi Yoshikado and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2018, 46 (7) 924-933; DOI: https://doi.org/10.1124/dmd.117.079210

  2. Kosa, Rachel E.

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

  3. Krausz, Kristopher W.

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

  4. Kumer, Sean C.

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

L

  1. Lai, Yurong

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

  2. Lee, Caroline

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

  3. Legangneux, Eric

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

  4. Li, Wenkui

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

  5. Li, Zhijie

    1. Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter
      Danyi Lu, Dong Dong, Qian Xie, Zhijie Li and Baojian Wu
      Drug Metabolism and Disposition July 2018, 46 (7) 970-979; DOI: https://doi.org/10.1124/dmd.118.080804

  6. Liao, Mingxiang

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

  7. Liederer, Bianca M.

    1. Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats
      Matthew R. Durk, Gauri Deshmukh, Nicole Valle, Xiao Ding, Bianca M. Liederer and Xingrong Liu
      Drug Metabolism and Disposition July 2018, 46 (7) 964-969; DOI: https://doi.org/10.1124/dmd.118.080697

  8. Lin, Yvonne S.

    1. Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach
      Emily J. Johnson, Vanessa González-Peréz, Dan-Dan Tian, Yvonne S. Lin, Jashvant D. Unadkat, Allan E. Rettie, Danny D. Shen, Jeannine S. McCune and Mary F. Paine
      Drug Metabolism and Disposition July 2018, 46 (7) 1046-1052; DOI: https://doi.org/10.1124/dmd.118.081273

  9. Liu, Xingrong

    1. Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats
      Matthew R. Durk, Gauri Deshmukh, Nicole Valle, Xiao Ding, Bianca M. Liederer and Xingrong Liu
      Drug Metabolism and Disposition July 2018, 46 (7) 964-969; DOI: https://doi.org/10.1124/dmd.118.080697

  10. Lockwood, Peter

    1. Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction
      Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
      Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457

  11. Lu, Danyi

    1. Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter
      Danyi Lu, Dong Dong, Qian Xie, Zhijie Li and Baojian Wu
      Drug Metabolism and Disposition July 2018, 46 (7) 970-979; DOI: https://doi.org/10.1124/dmd.118.080804

M

  1. Mancuso, Jessica

    1. Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction
      Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
      Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457

  2. Mathias, Anita

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

  3. McCune, Jeannine S.

    1. Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach
      Emily J. Johnson, Vanessa González-Peréz, Dan-Dan Tian, Yvonne S. Lin, Jashvant D. Unadkat, Allan E. Rettie, Danny D. Shen, Jeannine S. McCune and Mary F. Paine
      Drug Metabolism and Disposition July 2018, 46 (7) 1046-1052; DOI: https://doi.org/10.1124/dmd.118.081273
    2. Recommended Approaches for Pharmacokinetic Natural Product-Drug Interaction Research: a NaPDI Center Commentary
      Mary F. Paine, Danny D. Shen and Jeannine S. McCune
      Drug Metabolism and Disposition July 2018, 46 (7) 1041-1045; DOI: https://doi.org/10.1124/dmd.117.079962

  4. Meissner, Axel

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

  5. Michalewicz, Meeghan

    1. Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling
      Pallabi Mitra, Samantha Weinheimer, Meeghan Michalewicz and Mitchell E. Taub
      Drug Metabolism and Disposition July 2018, 46 (7) 953-963; DOI: https://doi.org/10.1124/dmd.118.080614

  6. Mitra, Pallabi

    1. Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling
      Pallabi Mitra, Samantha Weinheimer, Meeghan Michalewicz and Mitchell E. Taub
      Drug Metabolism and Disposition July 2018, 46 (7) 953-963; DOI: https://doi.org/10.1124/dmd.118.080614

  7. Modi, Sweta

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

N

  1. Niosi, Mark

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

  2. Nufer, Robert

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

O

  1. Obach, R. Scott

    1. Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction
      Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
      Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457

P

  1. Paine, Mary F.

    1. Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach
      Emily J. Johnson, Vanessa González-Peréz, Dan-Dan Tian, Yvonne S. Lin, Jashvant D. Unadkat, Allan E. Rettie, Danny D. Shen, Jeannine S. McCune and Mary F. Paine
      Drug Metabolism and Disposition July 2018, 46 (7) 1046-1052; DOI: https://doi.org/10.1124/dmd.118.081273
    2. Recommended Approaches for Pharmacokinetic Natural Product-Drug Interaction Research: a NaPDI Center Commentary
      Mary F. Paine, Danny D. Shen and Jeannine S. McCune
      Drug Metabolism and Disposition July 2018, 46 (7) 1041-1045; DOI: https://doi.org/10.1124/dmd.117.079962

  2. Panetta, John C.

    1. Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice
      Samit Ganguly, John C. Panetta, Jessica K. Roberts and Erin G. Schuetz
      Drug Metabolism and Disposition July 2018, 46 (7) 1014-1022; DOI: https://doi.org/10.1124/dmd.117.078360

  3. Peter van Marle, Sjoerd

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

  4. Prasad, Bhagwat

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

R

  1. Rettie, Allan E.

    1. Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach
      Emily J. Johnson, Vanessa González-Peréz, Dan-Dan Tian, Yvonne S. Lin, Jashvant D. Unadkat, Allan E. Rettie, Danny D. Shen, Jeannine S. McCune and Mary F. Paine
      Drug Metabolism and Disposition July 2018, 46 (7) 1046-1052; DOI: https://doi.org/10.1124/dmd.118.081273

  2. Roberts, Jessica K.

    1. Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice
      Samit Ganguly, John C. Panetta, Jessica K. Roberts and Erin G. Schuetz
      Drug Metabolism and Disposition July 2018, 46 (7) 1014-1022; DOI: https://doi.org/10.1124/dmd.117.078360

  3. Rodrigues, A. David

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

  4. Ryu, Sangwoo

    1. 11β-Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism
      Xin Yang, Wenyi Hua, Sangwoo Ryu, Phillip Yates, Cheng Chang, Hui Zhang and Li Di
      Drug Metabolism and Disposition July 2018, 46 (7) 1023-1029; DOI: https://doi.org/10.1124/dmd.118.081083

S

  1. Salphati, Laurent

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

  2. Sawant-Basak, Aarti

    1. Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction
      Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
      Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457

  3. Schildknegt, Klaas

    1. Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction
      Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
      Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457

  4. Schroer, Kirsten

    1. Open Access
      Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
      Ulrike Glaenzel, Yi Jin, Robert Nufer, Wenkui Li, Kirsten Schroer, Sylvie Adam-Stitah, Sjoerd Peter van Marle, Eric Legangneux, Hubert Borell, Alexander D. James, Axel Meissner, Gian Camenisch and Anne Gardin
      Drug Metabolism and Disposition July 2018, 46 (7) 1001-1013; DOI: https://doi.org/10.1124/dmd.117.079574

  5. Schuetz, Erin G.

    1. Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice
      Samit Ganguly, John C. Panetta, Jessica K. Roberts and Erin G. Schuetz
      Drug Metabolism and Disposition July 2018, 46 (7) 1014-1022; DOI: https://doi.org/10.1124/dmd.117.078360

  6. Shen, Danny D.

    1. Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach
      Emily J. Johnson, Vanessa González-Peréz, Dan-Dan Tian, Yvonne S. Lin, Jashvant D. Unadkat, Allan E. Rettie, Danny D. Shen, Jeannine S. McCune and Mary F. Paine
      Drug Metabolism and Disposition July 2018, 46 (7) 1046-1052; DOI: https://doi.org/10.1124/dmd.118.081273
    2. Recommended Approaches for Pharmacokinetic Natural Product-Drug Interaction Research: a NaPDI Center Commentary
      Mary F. Paine, Danny D. Shen and Jeannine S. McCune
      Drug Metabolism and Disposition July 2018, 46 (7) 1041-1045; DOI: https://doi.org/10.1124/dmd.117.079962

  7. Sugiyama, Yuichi

    1. Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling
      Yoshiaki Yao, Kota Toshimoto, Soo-Jin Kim, Takashi Yoshikado and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2018, 46 (7) 924-933; DOI: https://doi.org/10.1124/dmd.117.079210

  8. Sun, Dongxue

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

T

  1. Taub, Mitchell E.

    1. Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling
      Pallabi Mitra, Samantha Weinheimer, Meeghan Michalewicz and Mitchell E. Taub
      Drug Metabolism and Disposition July 2018, 46 (7) 953-963; DOI: https://doi.org/10.1124/dmd.118.080614

  2. Tian, Dan-Dan

    1. Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach
      Emily J. Johnson, Vanessa González-Peréz, Dan-Dan Tian, Yvonne S. Lin, Jashvant D. Unadkat, Allan E. Rettie, Danny D. Shen, Jeannine S. McCune and Mary F. Paine
      Drug Metabolism and Disposition July 2018, 46 (7) 1046-1052; DOI: https://doi.org/10.1124/dmd.118.081273

  3. Toshimoto, Kota

    1. Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling
      Yoshiaki Yao, Kota Toshimoto, Soo-Jin Kim, Takashi Yoshikado and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2018, 46 (7) 924-933; DOI: https://doi.org/10.1124/dmd.117.079210

  4. Tremaine, Larry M.

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

  5. Tse, Susanna

    1. Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction
      Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
      Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457

U

  1. Ufuk, Ayşe

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

  2. Unadkat, Jashvant D.

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523
    2. Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach
      Emily J. Johnson, Vanessa González-Peréz, Dan-Dan Tian, Yvonne S. Lin, Jashvant D. Unadkat, Allan E. Rettie, Danny D. Shen, Jeannine S. McCune and Mary F. Paine
      Drug Metabolism and Disposition July 2018, 46 (7) 1046-1052; DOI: https://doi.org/10.1124/dmd.118.081273

V

  1. Valle, Nicole

    1. Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats
      Matthew R. Durk, Gauri Deshmukh, Nicole Valle, Xiao Ding, Bianca M. Liederer and Xingrong Liu
      Drug Metabolism and Disposition July 2018, 46 (7) 964-969; DOI: https://doi.org/10.1124/dmd.118.080697

  2. Varma, Manthena V. S.

    1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance
      Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin and J. Brian Houston
      Drug Metabolism and Disposition July 2018, 46 (7) 989-1000; DOI: https://doi.org/10.1124/dmd.118.081315

W

  1. Weinheimer, Samantha

    1. Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling
      Pallabi Mitra, Samantha Weinheimer, Meeghan Michalewicz and Mitchell E. Taub
      Drug Metabolism and Disposition July 2018, 46 (7) 953-963; DOI: https://doi.org/10.1124/dmd.118.080614

  2. Wu, Baojian

    1. Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics
      Fangjun Yu, Tianpeng Zhang, Lianxia Guo and Baojian Wu
      Drug Metabolism and Disposition July 2018, 46 (7) 980-988; DOI: https://doi.org/10.1124/dmd.118.080895
    2. Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter
      Danyi Lu, Dong Dong, Qian Xie, Zhijie Li and Baojian Wu
      Drug Metabolism and Disposition July 2018, 46 (7) 970-979; DOI: https://doi.org/10.1124/dmd.118.080804

X

  1. Xiao, Guangqing

    1. Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
      Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer and Jashvant D. Unadkat
      Drug Metabolism and Disposition July 2018, 46 (7) 943-952; DOI: https://doi.org/10.1124/dmd.118.080523

  2. Xie, Cen

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

  3. Xie, Qian

    1. Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter
      Danyi Lu, Dong Dong, Qian Xie, Zhijie Li and Baojian Wu
      Drug Metabolism and Disposition July 2018, 46 (7) 970-979; DOI: https://doi.org/10.1124/dmd.118.080804

Y

  1. Yagai, Tomoki

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

  2. Yan, Tingting

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

  3. Yang, Xin

    1. 11β-Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism
      Xin Yang, Wenyi Hua, Sangwoo Ryu, Phillip Yates, Cheng Chang, Hui Zhang and Li Di
      Drug Metabolism and Disposition July 2018, 46 (7) 1023-1029; DOI: https://doi.org/10.1124/dmd.118.081083

  4. Yang, Xiuwei

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

  5. Yao, Yoshiaki

    1. Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling
      Yoshiaki Yao, Kota Toshimoto, Soo-Jin Kim, Takashi Yoshikado and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2018, 46 (7) 924-933; DOI: https://doi.org/10.1124/dmd.117.079210

  6. Yates, Phillip

    1. 11β-Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism
      Xin Yang, Wenyi Hua, Sangwoo Ryu, Phillip Yates, Cheng Chang, Hui Zhang and Li Di
      Drug Metabolism and Disposition July 2018, 46 (7) 1023-1029; DOI: https://doi.org/10.1124/dmd.118.081083

  7. Yoshikado, Takashi

    1. Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling
      Yoshiaki Yao, Kota Toshimoto, Soo-Jin Kim, Takashi Yoshikado and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2018, 46 (7) 924-933; DOI: https://doi.org/10.1124/dmd.117.079210

  8. Yu, Fangjun

    1. Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics
      Fangjun Yu, Tianpeng Zhang, Lianxia Guo and Baojian Wu
      Drug Metabolism and Disposition July 2018, 46 (7) 980-988; DOI: https://doi.org/10.1124/dmd.118.080895

Z

  1. Zhang, Hui

    1. 11β-Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism
      Xin Yang, Wenyi Hua, Sangwoo Ryu, Phillip Yates, Cheng Chang, Hui Zhang and Li Di
      Drug Metabolism and Disposition July 2018, 46 (7) 1023-1029; DOI: https://doi.org/10.1124/dmd.118.081083

  2. Zhang, Lei

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

  3. Zhang, Tianpeng

    1. Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics
      Fangjun Yu, Tianpeng Zhang, Lianxia Guo and Baojian Wu
      Drug Metabolism and Disposition July 2018, 46 (7) 980-988; DOI: https://doi.org/10.1124/dmd.118.080895

  4. Zhang, Youbo

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

  5. Zheng, Yiran

    1. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis
      Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez
      Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176
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