Article Figures & Data
Figures
Tables
Data Supplement
- Supplemental Data -
Supplemental Figure 1 - Ketamine one-compartmental distribution with zero order absorption for PO and first-order absorption for the IP dosing and first-order elimination from the central compartment
Supplemental Figure 2 - Diagnostic plots – observed vs. population and individual predicted ketamine concentrations
Supplemental Figure 3 - Diagnostic residual plots
Supplemental Figure 4 - Normalized prediction distribution error (NPDE) plots
Supplemental Figure 5 - Ketamine brain/serum ratios in wild-type, PgpKO and Pgp/Bcrp-dKO mice
Supplemental Table 1 - Noncompartmental analysis parameters for Ketamine IP and PO PK at 100 mg/kg
Supplemental Table 2 - Descriptive Statistics of Ketamine induced dLORR in male FVB mice (WT, Bcrp -/-, Pgp -/-, Bcrp-Pgp -/-)
Supplemental Table 3 - Descriptive statistics of Ketamine induced Loss of righting reflex (LORR) in male WT FVB mice with or without 100 mg/kg oral Elacridar 1.5 hours before intraperitoneal ketamine dosing
- Supplemental Data -