Research ArticleArticle
Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction
Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
Drug Metabolism and Disposition July 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457
Aarti Sawant-Basak
Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Cambridge, Massachusetts (A.S.-B.); Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Groton, Connecticut (R.S.O., A.D., H.G., S.T.); Pfizer Global Product Development, Groton, Connecticut (P.L.); Pfizer Worldwide Research and Development Pharmaceutical Sciences Chemical Research and Development, Groton, Connecticut (K.S.); Pfizer Worldwide Research and Development, Research Statistics, Cambridge, Massachusetts (J.M.); and Pfizer Neuroscience and Pain Research Unit, Worldwide Research and Development, Cambridge, Massachusetts (T.A.C.)
R. Scott Obach
Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Cambridge, Massachusetts (A.S.-B.); Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Groton, Connecticut (R.S.O., A.D., H.G., S.T.); Pfizer Global Product Development, Groton, Connecticut (P.L.); Pfizer Worldwide Research and Development Pharmaceutical Sciences Chemical Research and Development, Groton, Connecticut (K.S.); Pfizer Worldwide Research and Development, Research Statistics, Cambridge, Massachusetts (J.M.); and Pfizer Neuroscience and Pain Research Unit, Worldwide Research and Development, Cambridge, Massachusetts (T.A.C.)
Angela Doran
Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Cambridge, Massachusetts (A.S.-B.); Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Groton, Connecticut (R.S.O., A.D., H.G., S.T.); Pfizer Global Product Development, Groton, Connecticut (P.L.); Pfizer Worldwide Research and Development Pharmaceutical Sciences Chemical Research and Development, Groton, Connecticut (K.S.); Pfizer Worldwide Research and Development, Research Statistics, Cambridge, Massachusetts (J.M.); and Pfizer Neuroscience and Pain Research Unit, Worldwide Research and Development, Cambridge, Massachusetts (T.A.C.)
Peter Lockwood
Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Cambridge, Massachusetts (A.S.-B.); Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Groton, Connecticut (R.S.O., A.D., H.G., S.T.); Pfizer Global Product Development, Groton, Connecticut (P.L.); Pfizer Worldwide Research and Development Pharmaceutical Sciences Chemical Research and Development, Groton, Connecticut (K.S.); Pfizer Worldwide Research and Development, Research Statistics, Cambridge, Massachusetts (J.M.); and Pfizer Neuroscience and Pain Research Unit, Worldwide Research and Development, Cambridge, Massachusetts (T.A.C.)
Klaas Schildknegt
Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Cambridge, Massachusetts (A.S.-B.); Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Groton, Connecticut (R.S.O., A.D., H.G., S.T.); Pfizer Global Product Development, Groton, Connecticut (P.L.); Pfizer Worldwide Research and Development Pharmaceutical Sciences Chemical Research and Development, Groton, Connecticut (K.S.); Pfizer Worldwide Research and Development, Research Statistics, Cambridge, Massachusetts (J.M.); and Pfizer Neuroscience and Pain Research Unit, Worldwide Research and Development, Cambridge, Massachusetts (T.A.C.)
Hongying Gao
Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Cambridge, Massachusetts (A.S.-B.); Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Groton, Connecticut (R.S.O., A.D., H.G., S.T.); Pfizer Global Product Development, Groton, Connecticut (P.L.); Pfizer Worldwide Research and Development Pharmaceutical Sciences Chemical Research and Development, Groton, Connecticut (K.S.); Pfizer Worldwide Research and Development, Research Statistics, Cambridge, Massachusetts (J.M.); and Pfizer Neuroscience and Pain Research Unit, Worldwide Research and Development, Cambridge, Massachusetts (T.A.C.)
Jessica Mancuso
Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Cambridge, Massachusetts (A.S.-B.); Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Groton, Connecticut (R.S.O., A.D., H.G., S.T.); Pfizer Global Product Development, Groton, Connecticut (P.L.); Pfizer Worldwide Research and Development Pharmaceutical Sciences Chemical Research and Development, Groton, Connecticut (K.S.); Pfizer Worldwide Research and Development, Research Statistics, Cambridge, Massachusetts (J.M.); and Pfizer Neuroscience and Pain Research Unit, Worldwide Research and Development, Cambridge, Massachusetts (T.A.C.)
Susanna Tse
Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Cambridge, Massachusetts (A.S.-B.); Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Groton, Connecticut (R.S.O., A.D., H.G., S.T.); Pfizer Global Product Development, Groton, Connecticut (P.L.); Pfizer Worldwide Research and Development Pharmaceutical Sciences Chemical Research and Development, Groton, Connecticut (K.S.); Pfizer Worldwide Research and Development, Research Statistics, Cambridge, Massachusetts (J.M.); and Pfizer Neuroscience and Pain Research Unit, Worldwide Research and Development, Cambridge, Massachusetts (T.A.C.)
Thomas A. Comery
Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Cambridge, Massachusetts (A.S.-B.); Pfizer Worldwide Research and Development, Pharmacokinetics, Dynamics and Metabolism (PDM), Groton, Connecticut (R.S.O., A.D., H.G., S.T.); Pfizer Global Product Development, Groton, Connecticut (P.L.); Pfizer Worldwide Research and Development Pharmaceutical Sciences Chemical Research and Development, Groton, Connecticut (K.S.); Pfizer Worldwide Research and Development, Research Statistics, Cambridge, Massachusetts (J.M.); and Pfizer Neuroscience and Pain Research Unit, Worldwide Research and Development, Cambridge, Massachusetts (T.A.C.)
Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleArticle
Novel Sulfonamide Metabolite Explains Ketoconazole DDI
Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
Drug Metabolism and Disposition July 1, 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457
Research ArticleArticle
Novel Sulfonamide Metabolite Explains Ketoconazole DDI
Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse and Thomas A. Comery
Drug Metabolism and Disposition July 1, 2018, 46 (7) 934-942; DOI: https://doi.org/10.1124/dmd.118.080457
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement