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Drug Metabolism & Disposition

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Table of Contents

September 01, 2018; Volume 46,Issue 9

Minireview

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    The Roles of Xenobiotic Receptors: Beyond Chemical Disposition
    Bryan Mackowiak, Jessica Hodge, Sydney Stern and Hongbing Wang
    Drug Metabolism and Disposition September 2018, 46 (9) 1361-1371; DOI: https://doi.org/10.1124/dmd.118.081042

Articles

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    Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Organic Anion Transporting Polypeptides
    Kazuya Ishida, Mohammed Ullah, Beáta Tóth, Viktoria Juhasz and Jashvant D. Unadkat
    Drug Metabolism and Disposition September 2018, 46 (9) 1251-1258; DOI: https://doi.org/10.1124/dmd.118.080770
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    An Investigation into the Prediction of the Plasma Concentration-Time Profile and Its Interindividual Variability for a Range of Flavin-Containing Monooxygenase Substrates Using a Physiologically Based Pharmacokinetic Modeling Approach
    Venkatesh Pilla Reddy, Barry C. Jones, Nicola Colclough, Abhishek Srivastava, Joanne Wilson and Danxi Li
    Drug Metabolism and Disposition September 2018, 46 (9) 1259-1267; DOI: https://doi.org/10.1124/dmd.118.080648
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    Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader
    Tashinga E. Bapiro, Andy Sykes, Scott Martin, Michael Davies, James W. T. Yates, Matthias Hoch, Helen E. Rollison and Barry Jones
    Drug Metabolism and Disposition September 2018, 46 (9) 1268-1276; DOI: https://doi.org/10.1124/dmd.118.081539
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    Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 in Tissue-Selective Accumulation of Para-Hydroxymethamphetamine
    David J. Wagner, Laura M. Shireman, Sojung Ahn, Danny D. Shen and Joanne Wang
    Drug Metabolism and Disposition September 2018, 46 (9) 1277-1284; DOI: https://doi.org/10.1124/dmd.118.082131
  • Open Access
    Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance
    Jane R. Kenny, Diane Ramsden, David B. Buckley, Shannon Dallas, Conrad Fung, Michael Mohutsky, Heidi J. Einolf, Liangfu Chen, Joshua G. Dekeyser, Maria Fitzgerald, Theunis C. Goosen, Y. Amy Siu, Robert L. Walsky, George Zhang, Donald Tweedie and Niresh Hariparsad
    Drug Metabolism and Disposition September 2018, 46 (9) 1285-1303; DOI: https://doi.org/10.1124/dmd.118.081927
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    Decreased Kidney Function Is Associated with Enhanced Hepatic Flavin Monooxygenase Activity and Increased Circulating Trimethylamine N-Oxide Concentrations in Mice
    Cassandra Johnson, Alexander J. Prokopienko, Raymond E. West, Thomas D. Nolin and Jason R. Stubbs
    Drug Metabolism and Disposition September 2018, 46 (9) 1304-1309; DOI: https://doi.org/10.1124/dmd.118.081646
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    Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation
    Tingting Yan, Hong Wang, Lijuan Cao, Qiong Wang, Shogo Takahashi, Tomoki Yagai, Guolin Li, Kristopher W. Krausz, Guangji Wang, Frank J. Gonzalez and Haiping Hao
    Drug Metabolism and Disposition September 2018, 46 (9) 1310-1319; DOI: https://doi.org/10.1124/dmd.118.082008
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    Differences in the In Vivo and In Vitro Metabolism of Imrecoxib in Humans: Formation of the Rate-Limiting Aldehyde Intermediate
    Xiangyu Hou, Jialan Zhou, Songda Yu, Lei Zhou, Yifan Zhang, Dafang Zhong and Xiaoyan Chen
    Drug Metabolism and Disposition September 2018, 46 (9) 1320-1328; DOI: https://doi.org/10.1124/dmd.118.081182
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    Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 versus Neonatal Cytochrome P450 3A7
    Malika P. Godamudunage, Anne M. Grech and Emily E. Scott
    Drug Metabolism and Disposition September 2018, 46 (9) 1329-1337; DOI: https://doi.org/10.1124/dmd.118.082032
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    Recellularized Native Kidney Scaffolds as a Novel Tool in Nephrotoxicity Screening
    Michele Fedecostante, Koen G. C. Westphal, Michele F. Buono, Natalia Sanchez Romero, Martijn J. Wilmer, Janis Kerkering, Pedro Miguel Baptista, Joost G. Hoenderop and Rosalinde Masereeuw
    Drug Metabolism and Disposition September 2018, 46 (9) 1338-1350; DOI: https://doi.org/10.1124/dmd.118.080721
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    Content and Activities of UGT2B7 in Human Liver In Vitro and Predicted In Vivo: A Bottom-Up Approach
    Chen Xu, Jie Gao, Hai-Feng Zhang, Na Gao, Yuan-yuan Guo, Yan Fang, Qiang Wen and Hai-Ling Qiao
    Drug Metabolism and Disposition September 2018, 46 (9) 1351-1359; DOI: https://doi.org/10.1124/dmd.118.082024
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    Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent CYP1A1 Induction
    Duan Liu, Sisi Qin, Balmiki Ray, Krishna R. Kalari, Liewei Wang and Richard M. Weinshilboum
    Drug Metabolism and Disposition September 2018, 46 (9) 1372-1381; DOI: https://doi.org/10.1124/dmd.118.082164

Notice of Retraction

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    Notice of Retraction
    Drug Metabolism and Disposition September 2018, 46 (9) 1360; DOI: https://doi.org/10.1124/dmd.115.069229retraction

Errata

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    Correction to “Metabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis”
    Drug Metabolism and Disposition September 2018, 46 (9) 1382; DOI: https://doi.org/10.1124/dmd.117.077511err
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    Correction to “Maternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant Rats”
    Drug Metabolism and Disposition September 2018, 46 (9) 1383; DOI: https://doi.org/10.1124/dmd.117.079186err
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Drug Metabolism and Disposition: 46 (9)
Drug Metabolism and Disposition
Vol. 46, Issue 9
1 Sep 2018
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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