Table of Contents

Articles

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  Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Organic Anion Transporting Polypeptides

  Kazuya Ishida, Mohammed Ullah, Beáta Tóth, Viktoria Juhasz and Jashvant D. Unadkat

  Drug Metabolism and Disposition September 2018, 46 (9) 1251-1258; DOI: https://doi.org/10.1124/dmd.118.080770
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  An Investigation into the Prediction of the Plasma Concentration-Time Profile and Its Interindividual Variability for a Range of Flavin-Containing Monooxygenase Substrates Using a Physiologically Based Pharmacokinetic Modeling Approach

  Venkatesh Pilla Reddy, Barry C. Jones, Nicola Colclough, Abhishek Srivastava, Joanne Wilson and Danxi Li

  Drug Metabolism and Disposition September 2018, 46 (9) 1259-1267; DOI: https://doi.org/10.1124/dmd.118.080648
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  Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader

  Tashinga E. Bapiro, Andy Sykes, Scott Martin, Michael Davies, James W. T. Yates, Matthias Hoch, Helen E. Rollison and Barry Jones

  Drug Metabolism and Disposition September 2018, 46 (9) 1268-1276; DOI: https://doi.org/10.1124/dmd.118.081539
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  Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 in Tissue-Selective Accumulation of Para-Hydroxymethamphetamine

  David J. Wagner, Laura M. Shireman, Sojung Ahn, Danny D. Shen and Joanne Wang

  Drug Metabolism and Disposition September 2018, 46 (9) 1277-1284; DOI: https://doi.org/10.1124/dmd.118.082131
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  Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance

  Jane R. Kenny, Diane Ramsden, David B. Buckley, Shannon Dallas, Conrad Fung, Michael Mohutsky, Heidi J. Einolf, Liangfu Chen, Joshua G. Dekeyser, Maria Fitzgerald, Theunis C. Goosen, Y. Amy Siu, Robert L. Walsky, George Zhang, Donald Tweedie and Niresh Hariparsad

  Drug Metabolism and Disposition September 2018, 46 (9) 1285-1303; DOI: https://doi.org/10.1124/dmd.118.081927
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  Decreased Kidney Function Is Associated with Enhanced Hepatic Flavin Monooxygenase Activity and Increased Circulating Trimethylamine N-Oxide Concentrations in Mice

  Cassandra Johnson, Alexander J. Prokopienko, Raymond E. West, Thomas D. Nolin and Jason R. Stubbs

  Drug Metabolism and Disposition September 2018, 46 (9) 1304-1309; DOI: https://doi.org/10.1124/dmd.118.081646
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  Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation

  Tingting Yan, Hong Wang, Lijuan Cao, Qiong Wang, Shogo Takahashi, Tomoki Yagai, Guolin Li, Kristopher W. Krausz, Guangji Wang, Frank J. Gonzalez and Haiping Hao

  Drug Metabolism and Disposition September 2018, 46 (9) 1310-1319; DOI: https://doi.org/10.1124/dmd.118.082008
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  Differences in the In Vivo and In Vitro Metabolism of Imrecoxib in Humans: Formation of the Rate-Limiting Aldehyde Intermediate

  Xiangyu Hou, Jialan Zhou, Songda Yu, Lei Zhou, Yifan Zhang, Dafang Zhong and Xiaoyan Chen

  Drug Metabolism and Disposition September 2018, 46 (9) 1320-1328; DOI: https://doi.org/10.1124/dmd.118.081182
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  Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 versus Neonatal Cytochrome P450 3A7

  Malika P. Godamudunage, Anne M. Grech and Emily E. Scott

  Drug Metabolism and Disposition September 2018, 46 (9) 1329-1337; DOI: https://doi.org/10.1124/dmd.118.082032
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  Recellularized Native Kidney Scaffolds as a Novel Tool in Nephrotoxicity Screening

  Michele Fedecostante, Koen G. C. Westphal, Michele F. Buono, Natalia Sanchez Romero, Martijn J. Wilmer, Janis Kerkering, Pedro Miguel Baptista, Joost G. Hoenderop and Rosalinde Masereeuw

  Drug Metabolism and Disposition September 2018, 46 (9) 1338-1350; DOI: https://doi.org/10.1124/dmd.118.080721
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  Content and Activities of UGT2B7 in Human Liver In Vitro and Predicted In Vivo: A Bottom-Up Approach

  Chen Xu, Jie Gao, Hai-Feng Zhang, Na Gao, Yuan-yuan Guo, Yan Fang, Qiang Wen and Hai-Ling Qiao

  Drug Metabolism and Disposition September 2018, 46 (9) 1351-1359; DOI: https://doi.org/10.1124/dmd.118.082024
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  Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent CYP1A1 Induction

  Duan Liu, Sisi Qin, Balmiki Ray, Krishna R. Kalari, Liewei Wang and Richard M. Weinshilboum

  Drug Metabolism and Disposition September 2018, 46 (9) 1372-1381; DOI: https://doi.org/10.1124/dmd.118.082164