Table of Contents

Special Section On Pharmacokinetic And Drug Metabolism Properties Of Novel Therapeutic Modalities

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  Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities

  Brooke M. Rock and Robert S. Foti

  Drug Metabolism and Disposition October 2019, 47 (10) 1097-1099; DOI: https://doi.org/10.1124/dmd.119.088708
• Open Access

  Mechanisms Influencing the Pharmacokinetics and Disposition of Monoclonal Antibodies and Peptides

  Amita Datta-Mannan

  Drug Metabolism and Disposition October 2019, 47 (10) 1100-1110; DOI: https://doi.org/10.1124/dmd.119.086488
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  Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species

  Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock

  Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742
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  Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities

  Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh

  Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744
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  Effect of Size on Solid Tumor Disposition of Protein Therapeutics

  Zhe Li, Yingyi Li, Hsuan-Ping Chang, Hsueh-Yuan Chang, Leiming Guo and Dhaval K. Shah

  Drug Metabolism and Disposition October 2019, 47 (10) 1136-1145; DOI: https://doi.org/10.1124/dmd.119.087809
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  Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues

  Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop

  Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023
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  Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates

  Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh

  Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132
• Open Access

  Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species

  Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang

  Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395
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  Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA

  Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock

  Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967
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  In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters

  Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong

  Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098