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Drug Metabolism & Disposition

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Table of Contents

October 01, 2019; Volume 47,Issue 10

Special Section On Pharmacokinetic And Drug Metabolism Properties Of Novel Therapeutic Modalities

  • You have access
    Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities
    Brooke M. Rock and Robert S. Foti
    Drug Metabolism and Disposition October 2019, 47 (10) 1097-1099; DOI: https://doi.org/10.1124/dmd.119.088708
  • Open Access
    Mechanisms Influencing the Pharmacokinetics and Disposition of Monoclonal Antibodies and Peptides
    Amita Datta-Mannan
    Drug Metabolism and Disposition October 2019, 47 (10) 1100-1110; DOI: https://doi.org/10.1124/dmd.119.086488
  • Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
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    Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
    Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
    Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742
  • You have access
    Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
    Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
    Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744
  • You have access
    Effect of Size on Solid Tumor Disposition of Protein Therapeutics
    Zhe Li, Yingyi Li, Hsuan-Ping Chang, Hsueh-Yuan Chang, Leiming Guo and Dhaval K. Shah
    Drug Metabolism and Disposition October 2019, 47 (10) 1136-1145; DOI: https://doi.org/10.1124/dmd.119.087809
  • Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
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    Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
    Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
    Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023
  • Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
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    Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
    Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
    Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132
  • Open Access
    Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species
    Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang
    Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395
  • Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
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    Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
    Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
    Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967
  • You have access
    In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
    Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
    Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

Articles

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    Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1)
    Andaleeb Sajid, Natarajan Raju, Sabrina Lusvarghi, Shahrooz Vahedi, Rolf E. Swenson and Suresh V. Ambudkar
    Drug Metabolism and Disposition October 2019, 47 (10) 1013-1023; DOI: https://doi.org/10.1124/dmd.119.087734
  • Open Access
    Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding
    Ana P. Costa, Michael H. Court, Neal S. Burke, Zhaohui Zhu, Katrina L. Mealey and Nicolas F. Villarino
    Drug Metabolism and Disposition October 2019, 47 (10) 1024-1031; DOI: https://doi.org/10.1124/dmd.119.087304
  • You have access
    Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
    Veera Raghava Choudary Palacharla, Prathyusha Chunduru, Devender Reddy Ajjala, Gopinadh Bhyrapuneni, Ramakrishna Nirogi and Albert P. Li
    Drug Metabolism and Disposition October 2019, 47 (10) 1032-1039; DOI: https://doi.org/10.1124/dmd.119.088237
  • You have access
    Rhinacanthin-C Mediated Herb-Drug Interactions with Drug Transporters and Phase I Drug-Metabolizing Enzymes
    Wilasinee Dunkoksung, Nontima Vardhanabhuti, Pongpun Siripong and Suree Jianmongkol
    Drug Metabolism and Disposition October 2019, 47 (10) 1040-1049; DOI: https://doi.org/10.1124/dmd.118.085647
  • Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
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    Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
    Kimberly Holt, Min Ye, Swati Nagar and Ken Korzekwa
    Drug Metabolism and Disposition October 2019, 47 (10) 1050-1060; DOI: https://doi.org/10.1124/dmd.119.087973
  • Mechanism of H<sub>2</sub>S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
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    Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
    Martin Dulac, Citra Nagarathinam, Patrick Dansette, Daniel Mansuy and Jean-Luc Boucher
    Drug Metabolism and Disposition October 2019, 47 (10) 1061-1065; DOI: https://doi.org/10.1124/dmd.119.087205
  • You have access
    Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
    Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
    Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902
  • You have access
    Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites
    Renato J. Scialis, Lauren M. Aleksunes, Iván L. Csanaky, Curtis D. Klaassen and José E. Manautou
    Drug Metabolism and Disposition October 2019, 47 (10) 1080-1092; DOI: https://doi.org/10.1124/dmd.119.086603
  • You have access
    Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry
    Pan-Fen Wang, Alicia Neiner and Evan D. Kharasch
    Drug Metabolism and Disposition October 2019, 47 (10) 1195-1205; DOI: https://doi.org/10.1124/dmd.119.086348
  • You have access
    Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates
    Diane Ramsden, Conrad Fung, Niresh Hariparsad, Jane R. Kenny, Michael Mohutsky, Neil J. Parrott, Sarah Robertson and Donald J. Tweedie
    Drug Metabolism and Disposition October 2019, 47 (10) 1206-1221; DOI: https://doi.org/10.1124/dmd.119.087270
  • You have access
    Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions
    Hee Eun Kang, Melina M. Malinen, Chitra Saran, Paavo Honkakoski and Kim L.R. Brouwer
    Drug Metabolism and Disposition October 2019, 47 (10) 1222-1230; DOI: https://doi.org/10.1124/dmd.119.087676

Short Communication

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    The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions
    Ryuji Kato, Yoshio Ijiri, Tetsuya Hayashi and Jack Uetrecht
    Drug Metabolism and Disposition October 2019, 47 (10) 1093-1096; DOI: https://doi.org/10.1124/dmd.119.087981

Erratum

  • You have access
    Correction to “Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry”
    Drug Metabolism and Disposition October 2019, 47 (10) 1231; DOI: https://doi.org/10.1124/dmd.119.086348err
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Drug Metabolism and Disposition: 47 (10)
Drug Metabolism and Disposition
Vol. 47, Issue 10
1 Oct 2019
  • Table of Contents
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  • Special Section On Pharmacokinetic And Drug Metabolism Properties Of Novel Therapeutic Modalities
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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