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Index by author

October 01, 2019; Volume 47,Issue 10

A

  1. Ajjala, Devender Reddy

    1. Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
      Veera Raghava Choudary Palacharla, Prathyusha Chunduru, Devender Reddy Ajjala, Gopinadh Bhyrapuneni, Ramakrishna Nirogi and Albert P. Li
      Drug Metabolism and Disposition October 2019, 47 (10) 1032-1039; DOI: https://doi.org/10.1124/dmd.119.088237

  2. Aleksunes, Lauren M.

    1. Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites
      Renato J. Scialis, Lauren M. Aleksunes, Iván L. Csanaky, Curtis D. Klaassen and José E. Manautou
      Drug Metabolism and Disposition October 2019, 47 (10) 1080-1092; DOI: https://doi.org/10.1124/dmd.119.086603

  3. Aluri, Krishna

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

  4. Ambudkar, Suresh V.

    1. Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1)
      Andaleeb Sajid, Natarajan Raju, Sabrina Lusvarghi, Shahrooz Vahedi, Rolf E. Swenson and Suresh V. Ambudkar
      Drug Metabolism and Disposition October 2019, 47 (10) 1013-1023; DOI: https://doi.org/10.1124/dmd.119.087734

  5. Aral, Jennifer

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

B

  1. Basiri, Babak

    1. Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
      Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
      Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967

  2. Be, Xuhai

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  3. Berry, Loren

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  4. Bhyrapuneni, Gopinadh

    1. Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
      Veera Raghava Choudary Palacharla, Prathyusha Chunduru, Devender Reddy Ajjala, Gopinadh Bhyrapuneni, Ramakrishna Nirogi and Albert P. Li
      Drug Metabolism and Disposition October 2019, 47 (10) 1032-1039; DOI: https://doi.org/10.1124/dmd.119.088237

  5. Biswas, Kaustav

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  6. Boucher, Jean-Luc

    1. Mechanism of H<sub>2</sub>S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
      Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
      Martin Dulac, Citra Nagarathinam, Patrick Dansette, Daniel Mansuy and Jean-Luc Boucher
      Drug Metabolism and Disposition October 2019, 47 (10) 1061-1065; DOI: https://doi.org/10.1124/dmd.119.087205

  7. Brouwer, Kim L.R.

    1. Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions
      Hee Eun Kang, Melina M. Malinen, Chitra Saran, Paavo Honkakoski and Kim L.R. Brouwer
      Drug Metabolism and Disposition October 2019, 47 (10) 1222-1230; DOI: https://doi.org/10.1124/dmd.119.087676

  8. Bumpus, Namandjé N.

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  9. Burke, Neal S.

    1. Open Access
      Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding
      Ana P. Costa, Michael H. Court, Neal S. Burke, Zhaohui Zhu, Katrina L. Mealey and Nicolas F. Villarino
      Drug Metabolism and Disposition October 2019, 47 (10) 1024-1031; DOI: https://doi.org/10.1124/dmd.119.087304

C

  1. Cass, Robert T.

    1. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132

  2. Chang, Hsuan-Ping

    1. Effect of Size on Solid Tumor Disposition of Protein Therapeutics
      Zhe Li, Yingyi Li, Hsuan-Ping Chang, Hsueh-Yuan Chang, Leiming Guo and Dhaval K. Shah
      Drug Metabolism and Disposition October 2019, 47 (10) 1136-1145; DOI: https://doi.org/10.1124/dmd.119.087809

  3. Chang, Hsueh-Yuan

    1. Effect of Size on Solid Tumor Disposition of Protein Therapeutics
      Zhe Li, Yingyi Li, Hsuan-Ping Chang, Hsueh-Yuan Chang, Leiming Guo and Dhaval K. Shah
      Drug Metabolism and Disposition October 2019, 47 (10) 1136-1145; DOI: https://doi.org/10.1124/dmd.119.087809

  4. Chen, Nan

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  5. Chen, Yang

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  6. Cheng, Yuan

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  7. Chong, Saeho

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

  8. Chunduru, Prathyusha

    1. Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
      Veera Raghava Choudary Palacharla, Prathyusha Chunduru, Devender Reddy Ajjala, Gopinadh Bhyrapuneni, Ramakrishna Nirogi and Albert P. Li
      Drug Metabolism and Disposition October 2019, 47 (10) 1032-1039; DOI: https://doi.org/10.1124/dmd.119.088237

  9. Clausen, Valerie

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

  10. Conner, Kip

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  11. Costa, Ana P.

    1. Open Access
      Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding
      Ana P. Costa, Michael H. Court, Neal S. Burke, Zhaohui Zhu, Katrina L. Mealey and Nicolas F. Villarino
      Drug Metabolism and Disposition October 2019, 47 (10) 1024-1031; DOI: https://doi.org/10.1124/dmd.119.087304

  12. Court, Michael H.

    1. Open Access
      Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding
      Ana P. Costa, Michael H. Court, Neal S. Burke, Zhaohui Zhu, Katrina L. Mealey and Nicolas F. Villarino
      Drug Metabolism and Disposition October 2019, 47 (10) 1024-1031; DOI: https://doi.org/10.1124/dmd.119.087304

  13. Csanaky, Iván L.

    1. Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites
      Renato J. Scialis, Lauren M. Aleksunes, Iván L. Csanaky, Curtis D. Klaassen and José E. Manautou
      Drug Metabolism and Disposition October 2019, 47 (10) 1080-1092; DOI: https://doi.org/10.1124/dmd.119.086603

D

  1. Dansette, Patrick

    1. Mechanism of H<sub>2</sub>S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
      Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
      Martin Dulac, Citra Nagarathinam, Patrick Dansette, Daniel Mansuy and Jean-Luc Boucher
      Drug Metabolism and Disposition October 2019, 47 (10) 1061-1065; DOI: https://doi.org/10.1124/dmd.119.087205

  2. Datta-Mannan, Amita

    1. Open Access
      Mechanisms Influencing the Pharmacokinetics and Disposition of Monoclonal Antibodies and Peptides
      Amita Datta-Mannan
      Drug Metabolism and Disposition October 2019, 47 (10) 1100-1110; DOI: https://doi.org/10.1124/dmd.119.086488

  3. Deng, Yuzhong

    1. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132

  4. Dennin, Sean

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

  5. Di, Li

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  6. Dragovich, Peter S.

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023
    2. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132

  7. Dulac, Martin

    1. Mechanism of H<sub>2</sub>S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
      Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
      Martin Dulac, Citra Nagarathinam, Patrick Dansette, Daniel Mansuy and Jean-Luc Boucher
      Drug Metabolism and Disposition October 2019, 47 (10) 1061-1065; DOI: https://doi.org/10.1124/dmd.119.087205

  8. Dunkoksung, Wilasinee

    1. Rhinacanthin-C Mediated Herb-Drug Interactions with Drug Transporters and Phase I Drug-Metabolizing Enzymes
      Wilasinee Dunkoksung, Nontima Vardhanabhuti, Pongpun Siripong and Suree Jianmongkol
      Drug Metabolism and Disposition October 2019, 47 (10) 1040-1049; DOI: https://doi.org/10.1124/dmd.118.085647

F

  1. Falsey, James R.

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  2. Foti, Robert S.

    1. Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities
      Brooke M. Rock and Robert S. Foti
      Drug Metabolism and Disposition October 2019, 47 (10) 1097-1099; DOI: https://doi.org/10.1124/dmd.119.088708
    2. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  3. Fourie-O’Donohue, Aimee

    1. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132

  4. Fung, Conrad

    1. Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates
      Diane Ramsden, Conrad Fung, Niresh Hariparsad, Jane R. Kenny, Michael Mohutsky, Neil J. Parrott, Sarah Robertson and Donald J. Tweedie
      Drug Metabolism and Disposition October 2019, 47 (10) 1206-1221; DOI: https://doi.org/10.1124/dmd.119.087270

G

  1. Gampa, Gautham

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  2. Gaus, Hans

    1. Open Access
      Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species
      Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang
      Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395

  3. Geng, Donghao

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  4. Glaus, Charles

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  5. Greenlee, Sarah

    1. Open Access
      Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species
      Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang
      Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395

  6. Gu, Yongli

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

  7. Guo, Leiming

    1. Effect of Size on Solid Tumor Disposition of Protein Therapeutics
      Zhe Li, Yingyi Li, Hsuan-Ping Chang, Hsueh-Yuan Chang, Leiming Guo and Dhaval K. Shah
      Drug Metabolism and Disposition October 2019, 47 (10) 1136-1145; DOI: https://doi.org/10.1124/dmd.119.087809

H

  1. Hao, Yue

    1. Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
      Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
      Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967

  2. Hariparsad, Niresh

    1. Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates
      Diane Ramsden, Conrad Fung, Niresh Hariparsad, Jane R. Kenny, Michael Mohutsky, Neil J. Parrott, Sarah Robertson and Donald J. Tweedie
      Drug Metabolism and Disposition October 2019, 47 (10) 1206-1221; DOI: https://doi.org/10.1124/dmd.119.087270

  3. Hayashi, Tetsuya

    1. The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions
      Ryuji Kato, Yoshio Ijiri, Tetsuya Hayashi and Jack Uetrecht
      Drug Metabolism and Disposition October 2019, 47 (10) 1093-1096; DOI: https://doi.org/10.1124/dmd.119.087981

  4. Herberich, Brad

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  5. Hickman, Dean

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  6. Holt, Kimberly

    1. Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
      Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
      Kimberly Holt, Min Ye, Swati Nagar and Ken Korzekwa
      Drug Metabolism and Disposition October 2019, 47 (10) 1050-1060; DOI: https://doi.org/10.1124/dmd.119.087973

  7. Honkakoski, Paavo

    1. Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions
      Hee Eun Kang, Melina M. Malinen, Chitra Saran, Paavo Honkakoski and Kim L.R. Brouwer
      Drug Metabolism and Disposition October 2019, 47 (10) 1222-1230; DOI: https://doi.org/10.1124/dmd.119.087676

  8. Hop, Cornelis E.C.A.

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023
    2. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132
    3. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  9. Huang, Liyue

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  10. Huang, Xin

    1. Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
      Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
      Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967

  11. Humphreys, Sara C.

    1. Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
      Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
      Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967

  12. Hurh, Eunju

    1. Open Access
      Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species
      Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang
      Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395

I

  1. Ijiri, Yoshio

    1. The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions
      Ryuji Kato, Yoshio Ijiri, Tetsuya Hayashi and Jack Uetrecht
      Drug Metabolism and Disposition October 2019, 47 (10) 1093-1096; DOI: https://doi.org/10.1124/dmd.119.087981

  2. Ikotun, Tayo

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  3. Iqbal, Sajida

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

J

  1. Jiang, Jim

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

  2. Jianmongkol, Suree

    1. Rhinacanthin-C Mediated Herb-Drug Interactions with Drug Transporters and Phase I Drug-Metabolizing Enzymes
      Wilasinee Dunkoksung, Nontima Vardhanabhuti, Pongpun Siripong and Suree Jianmongkol
      Drug Metabolism and Disposition October 2019, 47 (10) 1040-1049; DOI: https://doi.org/10.1124/dmd.118.085647

K

  1. Kang, Hee Eun

    1. Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions
      Hee Eun Kang, Melina M. Malinen, Chitra Saran, Paavo Honkakoski and Kim L.R. Brouwer
      Drug Metabolism and Disposition October 2019, 47 (10) 1222-1230; DOI: https://doi.org/10.1124/dmd.119.087676

  2. Kato, Ryuji

    1. The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions
      Ryuji Kato, Yoshio Ijiri, Tetsuya Hayashi and Jack Uetrecht
      Drug Metabolism and Disposition October 2019, 47 (10) 1093-1096; DOI: https://doi.org/10.1124/dmd.119.087981

  3. Kenny, Jane R.

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744
    2. Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates
      Diane Ramsden, Conrad Fung, Niresh Hariparsad, Jane R. Kenny, Michael Mohutsky, Neil J. Parrott, Sarah Robertson and Donald J. Tweedie
      Drug Metabolism and Disposition October 2019, 47 (10) 1206-1221; DOI: https://doi.org/10.1124/dmd.119.087270

  4. Kharasch, Evan D.

    1. Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry
      Pan-Fen Wang, Alicia Neiner and Evan D. Kharasch
      Drug Metabolism and Disposition October 2019, 47 (10) 1195-1205; DOI: https://doi.org/10.1124/dmd.119.086348

  5. Khojasteh, S. Cyrus

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023
    2. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132
    3. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  6. Kim, Joohwan

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

  7. Klaassen, Curtis D.

    1. Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites
      Renato J. Scialis, Lauren M. Aleksunes, Iván L. Csanaky, Curtis D. Klaassen and José E. Manautou
      Drug Metabolism and Disposition October 2019, 47 (10) 1080-1092; DOI: https://doi.org/10.1124/dmd.119.086603

  8. Korzekwa, Ken

    1. Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
      Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
      Kimberly Holt, Min Ye, Swati Nagar and Ken Korzekwa
      Drug Metabolism and Disposition October 2019, 47 (10) 1050-1060; DOI: https://doi.org/10.1124/dmd.119.087973

  9. Kozak, Katherine R.

    1. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132

L

  1. Lade, Julie M.

    1. Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
      Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
      Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967

  2. Lai, Yurong

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  3. Li, Albert P.

    1. Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
      Veera Raghava Choudary Palacharla, Prathyusha Chunduru, Devender Reddy Ajjala, Gopinadh Bhyrapuneni, Ramakrishna Nirogi and Albert P. Li
      Drug Metabolism and Disposition October 2019, 47 (10) 1032-1039; DOI: https://doi.org/10.1124/dmd.119.088237

  4. Li, Hongyan

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  5. Li, Ping

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  6. Li, Yingyi

    1. Effect of Size on Solid Tumor Disposition of Protein Therapeutics
      Zhe Li, Yingyi Li, Hsuan-Ping Chang, Hsueh-Yuan Chang, Leiming Guo and Dhaval K. Shah
      Drug Metabolism and Disposition October 2019, 47 (10) 1136-1145; DOI: https://doi.org/10.1124/dmd.119.087809

  7. Li, Zhe

    1. Effect of Size on Solid Tumor Disposition of Protein Therapeutics
      Zhe Li, Yingyi Li, Hsuan-Ping Chang, Hsueh-Yuan Chang, Leiming Guo and Dhaval K. Shah
      Drug Metabolism and Disposition October 2019, 47 (10) 1136-1145; DOI: https://doi.org/10.1124/dmd.119.087809

  8. Liang, Limin

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  9. Liu, Li

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  10. Liu, Liling

    1. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132

  11. Liu, Xiaodong

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  12. Liu, Xingrong

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  13. Liu, Yichin

    1. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132

  14. Long, Jason

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  15. Lusvarghi, Sabrina

    1. Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1)
      Andaleeb Sajid, Natarajan Raju, Sabrina Lusvarghi, Shahrooz Vahedi, Rolf E. Swenson and Suresh V. Ambudkar
      Drug Metabolism and Disposition October 2019, 47 (10) 1013-1023; DOI: https://doi.org/10.1124/dmd.119.087734

M

  1. Ma, Yong

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023

  2. Malinen, Melina M.

    1. Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions
      Hee Eun Kang, Melina M. Malinen, Chitra Saran, Paavo Honkakoski and Kim L.R. Brouwer
      Drug Metabolism and Disposition October 2019, 47 (10) 1222-1230; DOI: https://doi.org/10.1124/dmd.119.087676

  3. Manautou, José E.

    1. Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites
      Renato J. Scialis, Lauren M. Aleksunes, Iván L. Csanaky, Curtis D. Klaassen and José E. Manautou
      Drug Metabolism and Disposition October 2019, 47 (10) 1080-1092; DOI: https://doi.org/10.1124/dmd.119.086603

  4. Mansuy, Daniel

    1. Mechanism of H<sub>2</sub>S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
      Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
      Martin Dulac, Citra Nagarathinam, Patrick Dansette, Daniel Mansuy and Jean-Luc Boucher
      Drug Metabolism and Disposition October 2019, 47 (10) 1061-1065; DOI: https://doi.org/10.1124/dmd.119.087205

  5. Matson, John

    1. Open Access
      Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species
      Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang
      Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395

  6. Mealey, Katrina L.

    1. Open Access
      Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding
      Ana P. Costa, Michael H. Court, Neal S. Burke, Zhaohui Zhu, Katrina L. Mealey and Nicolas F. Villarino
      Drug Metabolism and Disposition October 2019, 47 (10) 1024-1031; DOI: https://doi.org/10.1124/dmd.119.087304

  7. Miranda, Les P.

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  8. Mohutsky, Michael

    1. Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates
      Diane Ramsden, Conrad Fung, Niresh Hariparsad, Jane R. Kenny, Michael Mohutsky, Neil J. Parrott, Sarah Robertson and Donald J. Tweedie
      Drug Metabolism and Disposition October 2019, 47 (10) 1206-1221; DOI: https://doi.org/10.1124/dmd.119.087270

  9. Moyer, Bryan

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  10. Murray, Justin

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

N

  1. Nagapudi, Karthik

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  2. Nagar, Swati

    1. Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
      Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
      Kimberly Holt, Min Ye, Swati Nagar and Ken Korzekwa
      Drug Metabolism and Disposition October 2019, 47 (10) 1050-1060; DOI: https://doi.org/10.1124/dmd.119.087973

  3. Nagarathinam, Citra

    1. Mechanism of H<sub>2</sub>S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
      Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
      Martin Dulac, Citra Nagarathinam, Patrick Dansette, Daniel Mansuy and Jean-Luc Boucher
      Drug Metabolism and Disposition October 2019, 47 (10) 1061-1065; DOI: https://doi.org/10.1124/dmd.119.087205

  4. Neiner, Alicia

    1. Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry
      Pan-Fen Wang, Alicia Neiner and Evan D. Kharasch
      Drug Metabolism and Disposition October 2019, 47 (10) 1195-1205; DOI: https://doi.org/10.1124/dmd.119.086348

  5. Netirojjanakul, Chawita

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  6. Nirogi, Ramakrishna

    1. Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
      Veera Raghava Choudary Palacharla, Prathyusha Chunduru, Devender Reddy Ajjala, Gopinadh Bhyrapuneni, Ramakrishna Nirogi and Albert P. Li
      Drug Metabolism and Disposition October 2019, 47 (10) 1032-1039; DOI: https://doi.org/10.1124/dmd.119.088237

  7. Nixey, Thomas E.

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

P

  1. Palacharla, Veera Raghava Choudary

    1. Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
      Veera Raghava Choudary Palacharla, Prathyusha Chunduru, Devender Reddy Ajjala, Gopinadh Bhyrapuneni, Ramakrishna Nirogi and Albert P. Li
      Drug Metabolism and Disposition October 2019, 47 (10) 1032-1039; DOI: https://doi.org/10.1124/dmd.119.088237

  2. Parrott, Neil J.

    1. Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates
      Diane Ramsden, Conrad Fung, Niresh Hariparsad, Jane R. Kenny, Michael Mohutsky, Neil J. Parrott, Sarah Robertson and Donald J. Tweedie
      Drug Metabolism and Disposition October 2019, 47 (10) 1206-1221; DOI: https://doi.org/10.1124/dmd.119.087270

  3. Patilea-Vrana, Gabriela

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  4. Pillow, Thomas H.

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023
    2. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132

  5. Polson, Andrew

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023

  6. Post, Noah

    1. Open Access
      Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species
      Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang
      Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395

R

  1. Raju, Natarajan

    1. Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1)
      Andaleeb Sajid, Natarajan Raju, Sabrina Lusvarghi, Shahrooz Vahedi, Rolf E. Swenson and Suresh V. Ambudkar
      Drug Metabolism and Disposition October 2019, 47 (10) 1013-1023; DOI: https://doi.org/10.1124/dmd.119.087734

  2. Ramsden, Diane

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098
    2. Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates
      Diane Ramsden, Conrad Fung, Niresh Hariparsad, Jane R. Kenny, Michael Mohutsky, Neil J. Parrott, Sarah Robertson and Donald J. Tweedie
      Drug Metabolism and Disposition October 2019, 47 (10) 1206-1221; DOI: https://doi.org/10.1124/dmd.119.087270

  3. Robertson, Sarah

    1. Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates
      Diane Ramsden, Conrad Fung, Niresh Hariparsad, Jane R. Kenny, Michael Mohutsky, Neil J. Parrott, Sarah Robertson and Donald J. Tweedie
      Drug Metabolism and Disposition October 2019, 47 (10) 1206-1221; DOI: https://doi.org/10.1124/dmd.119.087270

  4. Rock, Brooke M.

    1. Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities
      Brooke M. Rock and Robert S. Foti
      Drug Metabolism and Disposition October 2019, 47 (10) 1097-1099; DOI: https://doi.org/10.1124/dmd.119.088708
    2. Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
      Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
      Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967

  5. Rock, Dan A.

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

S

  1. Sadowsky, Jack D.

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023
    2. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132

  2. Sajid, Andaleeb

    1. Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1)
      Andaleeb Sajid, Natarajan Raju, Sabrina Lusvarghi, Shahrooz Vahedi, Rolf E. Swenson and Suresh V. Ambudkar
      Drug Metabolism and Disposition October 2019, 47 (10) 1013-1023; DOI: https://doi.org/10.1124/dmd.119.087734

  3. Saran, Chitra

    1. Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions
      Hee Eun Kang, Melina M. Malinen, Chitra Saran, Paavo Honkakoski and Kim L.R. Brouwer
      Drug Metabolism and Disposition October 2019, 47 (10) 1222-1230; DOI: https://doi.org/10.1124/dmd.119.087676

  4. Scialis, Renato J.

    1. Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites
      Renato J. Scialis, Lauren M. Aleksunes, Iván L. Csanaky, Curtis D. Klaassen and José E. Manautou
      Drug Metabolism and Disposition October 2019, 47 (10) 1080-1092; DOI: https://doi.org/10.1124/dmd.119.086603

  5. Seneviratne, Herana Kamal

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  6. Shah, Dhaval K.

    1. Effect of Size on Solid Tumor Disposition of Protein Therapeutics
      Zhe Li, Yingyi Li, Hsuan-Ping Chang, Hsueh-Yuan Chang, Leiming Guo and Dhaval K. Shah
      Drug Metabolism and Disposition October 2019, 47 (10) 1136-1145; DOI: https://doi.org/10.1124/dmd.119.087809

  7. Sham, Kelvin

    1. Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
      Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
      Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967
    2. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  8. Siripong, Pongpun

    1. Rhinacanthin-C Mediated Herb-Drug Interactions with Drug Transporters and Phase I Drug-Metabolizing Enzymes
      Wilasinee Dunkoksung, Nontima Vardhanabhuti, Pongpun Siripong and Suree Jianmongkol
      Drug Metabolism and Disposition October 2019, 47 (10) 1040-1049; DOI: https://doi.org/10.1124/dmd.118.085647

  9. Smith, Richard

    1. Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
      Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
      Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967

  10. Soto, Marcus

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  11. Su, Dian

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023

  12. Swenson, Rolf E.

    1. Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1)
      Andaleeb Sajid, Natarajan Raju, Sabrina Lusvarghi, Shahrooz Vahedi, Rolf E. Swenson and Suresh V. Ambudkar
      Drug Metabolism and Disposition October 2019, 47 (10) 1013-1023; DOI: https://doi.org/10.1124/dmd.119.087734

T

  1. Tegley, Christopher M.

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  2. Thayer, Mai B.

    1. Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
      Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
      Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967

  3. Tran, Linh

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  4. Tweedie, Donald J.

    1. Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates
      Diane Ramsden, Conrad Fung, Niresh Hariparsad, Jane R. Kenny, Michael Mohutsky, Neil J. Parrott, Sarah Robertson and Donald J. Tweedie
      Drug Metabolism and Disposition October 2019, 47 (10) 1206-1221; DOI: https://doi.org/10.1124/dmd.119.087270

U

  1. Uetrecht, Jack

    1. The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions
      Ryuji Kato, Yoshio Ijiri, Tetsuya Hayashi and Jack Uetrecht
      Drug Metabolism and Disposition October 2019, 47 (10) 1093-1096; DOI: https://doi.org/10.1124/dmd.119.087981

  2. Unadkat, Jashvant D.

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

V

  1. Vahedi, Shahrooz

    1. Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1)
      Andaleeb Sajid, Natarajan Raju, Sabrina Lusvarghi, Shahrooz Vahedi, Rolf E. Swenson and Suresh V. Ambudkar
      Drug Metabolism and Disposition October 2019, 47 (10) 1013-1023; DOI: https://doi.org/10.1124/dmd.119.087734

  2. Vardhanabhuti, Nontima

    1. Rhinacanthin-C Mediated Herb-Drug Interactions with Drug Transporters and Phase I Drug-Metabolizing Enzymes
      Wilasinee Dunkoksung, Nontima Vardhanabhuti, Pongpun Siripong and Suree Jianmongkol
      Drug Metabolism and Disposition October 2019, 47 (10) 1040-1049; DOI: https://doi.org/10.1124/dmd.118.085647

  3. Villarino, Nicolas F.

    1. Open Access
      Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding
      Ana P. Costa, Michael H. Court, Neal S. Burke, Zhaohui Zhu, Katrina L. Mealey and Nicolas F. Villarino
      Drug Metabolism and Disposition October 2019, 47 (10) 1024-1031; DOI: https://doi.org/10.1124/dmd.119.087304

W

  1. Wang, Pan-Fen

    1. Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry
      Pan-Fen Wang, Alicia Neiner and Evan D. Kharasch
      Drug Metabolism and Disposition October 2019, 47 (10) 1195-1205; DOI: https://doi.org/10.1124/dmd.119.086348

  2. Wang, Wei

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023

  3. Wang, Yanfeng

    1. Open Access
      Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species
      Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang
      Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395

  4. Wang, Zhongjian

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  5. Wright, Matthew R.

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  6. Wu, Bin

    1. Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
      Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
      Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967
    2. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  7. Wu, Jing-Tao

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

X

  1. Xu, Jiong

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

Y

  1. Yang, Hanyu

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  2. Ye, Min

    1. Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
      Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
      Kimberly Holt, Min Ye, Swati Nagar and Ken Korzekwa
      Drug Metabolism and Disposition October 2019, 47 (10) 1050-1060; DOI: https://doi.org/10.1124/dmd.119.087973

  3. Yin, Lin

    1. Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
      Robert S. Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R. Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P. Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E. Nixey, Kelvin Sham, Marcus Soto, Christopher M. Tegley, Linh Tran, Bin Wu, Lin Yin and Dan A. Rock
      Drug Metabolism and Disposition October 2019, 47 (10) 1111-1121; DOI: https://doi.org/10.1124/dmd.119.087742

  4. Yu, Rosie

    1. Open Access
      Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species
      Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang
      Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395

  5. Yu, Shang-Fan

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023

Z

  1. Zak, Mark

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  2. Zang, Richard

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  3. Zerler, Brad

    1. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters
      Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim and Saeho Chong
      Drug Metabolism and Disposition October 2019, 47 (10) 1183-1194; DOI: https://doi.org/10.1124/dmd.119.087098

  4. Zhang, Donglu

    1. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
      Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop
      Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023
    2. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates
      Donglu Zhang, Aimee Fourie-O’Donohue, Peter S. Dragovich, Thomas H. Pillow, Jack D. Sadowsky, Katherine R. Kozak, Robert T. Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1156-1163; DOI: https://doi.org/10.1124/dmd.118.086132
    3. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  5. Zhang, Xiangping

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  6. Zhao, Kaijing

    1. Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
      Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu and Li Liu
      Drug Metabolism and Disposition October 2019, 47 (10) 1066-1079; DOI: https://doi.org/10.1124/dmd.118.085902

  7. Zhou, Lian

    1. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
      Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
      Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

  8. Zhu, Zhaohui

    1. Open Access
      Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding
      Ana P. Costa, Michael H. Court, Neal S. Burke, Zhaohui Zhu, Katrina L. Mealey and Nicolas F. Villarino
      Drug Metabolism and Disposition October 2019, 47 (10) 1024-1031; DOI: https://doi.org/10.1124/dmd.119.087304
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