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Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967
Sara C. Humphreys
Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, California (S.C.H., M.B.T., J.M.L., B.B., R.S., B.M.R.); Hybrid Modality Engineering Department, Amgen Research, Thousand Oaks, California (B.W., K.S.); and Molecular Engineering Department, Amgen Research, Cambridge, Massachusetts (Y.H., X.H.)
Mai B. Thayer
Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, California (S.C.H., M.B.T., J.M.L., B.B., R.S., B.M.R.); Hybrid Modality Engineering Department, Amgen Research, Thousand Oaks, California (B.W., K.S.); and Molecular Engineering Department, Amgen Research, Cambridge, Massachusetts (Y.H., X.H.)
Julie M. Lade
Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, California (S.C.H., M.B.T., J.M.L., B.B., R.S., B.M.R.); Hybrid Modality Engineering Department, Amgen Research, Thousand Oaks, California (B.W., K.S.); and Molecular Engineering Department, Amgen Research, Cambridge, Massachusetts (Y.H., X.H.)
Bin Wu
Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, California (S.C.H., M.B.T., J.M.L., B.B., R.S., B.M.R.); Hybrid Modality Engineering Department, Amgen Research, Thousand Oaks, California (B.W., K.S.); and Molecular Engineering Department, Amgen Research, Cambridge, Massachusetts (Y.H., X.H.)
Kelvin Sham
Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, California (S.C.H., M.B.T., J.M.L., B.B., R.S., B.M.R.); Hybrid Modality Engineering Department, Amgen Research, Thousand Oaks, California (B.W., K.S.); and Molecular Engineering Department, Amgen Research, Cambridge, Massachusetts (Y.H., X.H.)
Babak Basiri
Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, California (S.C.H., M.B.T., J.M.L., B.B., R.S., B.M.R.); Hybrid Modality Engineering Department, Amgen Research, Thousand Oaks, California (B.W., K.S.); and Molecular Engineering Department, Amgen Research, Cambridge, Massachusetts (Y.H., X.H.)
Yue Hao
Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, California (S.C.H., M.B.T., J.M.L., B.B., R.S., B.M.R.); Hybrid Modality Engineering Department, Amgen Research, Thousand Oaks, California (B.W., K.S.); and Molecular Engineering Department, Amgen Research, Cambridge, Massachusetts (Y.H., X.H.)
Xin Huang
Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, California (S.C.H., M.B.T., J.M.L., B.B., R.S., B.M.R.); Hybrid Modality Engineering Department, Amgen Research, Thousand Oaks, California (B.W., K.S.); and Molecular Engineering Department, Amgen Research, Cambridge, Massachusetts (Y.H., X.H.)
Richard Smith
Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, California (S.C.H., M.B.T., J.M.L., B.B., R.S., B.M.R.); Hybrid Modality Engineering Department, Amgen Research, Thousand Oaks, California (B.W., K.S.); and Molecular Engineering Department, Amgen Research, Cambridge, Massachusetts (Y.H., X.H.)
Brooke M. Rock
Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, California (S.C.H., M.B.T., J.M.L., B.B., R.S., B.M.R.); Hybrid Modality Engineering Department, Amgen Research, Thousand Oaks, California (B.W., K.S.); and Molecular Engineering Department, Amgen Research, Cambridge, Massachusetts (Y.H., X.H.)
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Research ArticleArticle
Plasma and Liver Protein Binding of GalNAc-Conjugated siRNA
Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
Drug Metabolism and Disposition October 1, 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967
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Plasma and Liver Protein Binding of GalNAc-Conjugated siRNA
Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
Drug Metabolism and Disposition October 1, 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967
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