Table of Contents

Articles

• You have access

  Kinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme Reactions

  F. Peter Guengerich

  Drug Metabolism and Disposition November 2019, 47 (11) 1232-1239; DOI: https://doi.org/10.1124/dmd.119.088732
• 

  You have access

  Impact of Different Selectivity between Soluble and Membrane-bound Forms of Carcinoembryonic Antigen (CEA) on the Target-mediated Disposition of Anti-CEA Monoclonal Antibodies

  Junko Iwano, Daisuke Shinmi, Kazuhiro Masuda, Takashi Murakami and Junichi Enokizono

  Drug Metabolism and Disposition November 2019, 47 (11) 1240-1246; DOI: https://doi.org/10.1124/dmd.119.088179
• 

  You have access

  Metabolism of Strained Rings: Glutathione S-transferase–Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation

  Xue-Qing Li, Gunnar Grönberg, Eva-Henriette Bangur, Martin A. Hayes, Neal Castagnoli and Lars Weidolf

  Drug Metabolism and Disposition November 2019, 47 (11) 1247-1256; DOI: https://doi.org/10.1124/dmd.119.088658
• You have access

  Interindividual Variation in CYP3A Activity Influences Lapatinib Bioactivation

  Jennifer E. Bissada, Vivian Truong, Arsany A. Abouda, Kahari J. Wines, Rachel D. Crouch and Klarissa D. Jackson

  Drug Metabolism and Disposition November 2019, 47 (11) 1257-1269; DOI: https://doi.org/10.1124/dmd.119.088823
• You have access

  Elucidation of N¹-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters

  Takeshi Miyake, Tadahaya Mizuno, Issey Takehara, Tatsuki Mochizuki, Miyuki Kimura, Shunji Matsuki, Shin Irie, Nobuaki Watanabe, Yukio Kato, Ichiro Ieiri, Kazuya Maeda, Osamu Ando and Hiroyuki Kusuhara

  Drug Metabolism and Disposition November 2019, 47 (11) 1270-1280; DOI: https://doi.org/10.1124/dmd.119.087262
• You have access

  Glutathione Conjugation and Protein Adduction Derived from Oxidative Debromination of Benzbromarone in Mice

  Hui Wang, Wenbao Wang, Bowen Gong, Zedan Wang, Yukun Feng, Weige Zhang, Shaojie Wang, Ying Peng and Jiang Zheng

  Drug Metabolism and Disposition November 2019, 47 (11) 1281-1290; DOI: https://doi.org/10.1124/dmd.119.087460
• 

  You have access

  Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban

  Eleanor Jing Yi Cheong, Denise Wun Xi Teo, Denise Xin Yi Chua and Eric Chun Yong Chan

  Drug Metabolism and Disposition November 2019, 47 (11) 1291-1306; DOI: https://doi.org/10.1124/dmd.119.086918
• You have access

  Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats

  Jae H. Chang, Yi-Chen Chen, Jonathan Cheong, Robert S. Jones and Jodie Pang

  Drug Metabolism and Disposition November 2019, 47 (11) 1307-1313; DOI: https://doi.org/10.1124/dmd.119.088278
• You have access

  Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability

  Stephanie E. Martinez, Jian Shi, Hao-Jie Zhu, Tania E. Perez Jimenez, Zhaohui Zhu and Michael H. Court

  Drug Metabolism and Disposition November 2019, 47 (11) 1314-1324; DOI: https://doi.org/10.1124/dmd.119.088070
• You have access

  A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach

  Mostafa I. Fekry, Yi Xiao, Jeannette Zinggeler Berg and F. Peter Guengerich

  Drug Metabolism and Disposition November 2019, 47 (11) 1325-1332; DOI: https://doi.org/10.1124/dmd.119.089086
• You have access

  The Molecular Mechanism Regulating Diurnal Rhythm of Flavin-Containing Monooxygenase 5 in Mouse Liver

  Min Chen, Baozhang Guan, Haiman Xu, Fangjun Yu, Tianpeng Zhang and Baojian Wu

  Drug Metabolism and Disposition November 2019, 47 (11) 1333-1342; DOI: https://doi.org/10.1124/dmd.119.088450
• You have access

  Glucocorticoids Increase Renal Excretion of Urate in Mice by Downregulating Urate Transporter 1

  Gentao Li, Lifeng Han, Ruicong Ma, Khawar Saeed, Hui Xiong, Curtis D. Klaassen, Yuanfu Lu and Youcai Zhang

  Drug Metabolism and Disposition November 2019, 47 (11) 1343-1351; DOI: https://doi.org/10.1124/dmd.119.087700
• 

  You have access

  Development of a Gold Nanoparticle–Functionalized Surface Plasmon Resonance Assay for the Sensitive Detection of Monoclonal Antibodies and Its Application in Pharmacokinetics

  Haihong Bai, Mei Yuan, Xiaojing Wang, Xinghe Wang and Jinjing Che

  Drug Metabolism and Disposition November 2019, 47 (11) 1361-1367; DOI: https://doi.org/10.1124/dmd.119.086249