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Table of Contents

November 01, 2019; Volume 47,Issue 11

Articles

  • You have access
    Kinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme Reactions
    F. Peter Guengerich
    Drug Metabolism and Disposition November 2019, 47 (11) 1232-1239; DOI: https://doi.org/10.1124/dmd.119.088732
  • Impact of Different Selectivity between Soluble and Membrane-bound Forms of Carcinoembryonic Antigen (CEA) on the Target-mediated Disposition of Anti-CEA Monoclonal Antibodies
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    Impact of Different Selectivity between Soluble and Membrane-bound Forms of Carcinoembryonic Antigen (CEA) on the Target-mediated Disposition of Anti-CEA Monoclonal Antibodies
    Junko Iwano, Daisuke Shinmi, Kazuhiro Masuda, Takashi Murakami and Junichi Enokizono
    Drug Metabolism and Disposition November 2019, 47 (11) 1240-1246; DOI: https://doi.org/10.1124/dmd.119.088179
  • Metabolism of Strained Rings: Glutathione <em>S</em>-transferase–Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation
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    Metabolism of Strained Rings: Glutathione S-transferase–Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation
    Xue-Qing Li, Gunnar Grönberg, Eva-Henriette Bangur, Martin A. Hayes, Neal Castagnoli and Lars Weidolf
    Drug Metabolism and Disposition November 2019, 47 (11) 1247-1256; DOI: https://doi.org/10.1124/dmd.119.088658
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    Interindividual Variation in CYP3A Activity Influences Lapatinib Bioactivation
    Jennifer E. Bissada, Vivian Truong, Arsany A. Abouda, Kahari J. Wines, Rachel D. Crouch and Klarissa D. Jackson
    Drug Metabolism and Disposition November 2019, 47 (11) 1257-1269; DOI: https://doi.org/10.1124/dmd.119.088823
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    Elucidation of N1-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters
    Takeshi Miyake, Tadahaya Mizuno, Issey Takehara, Tatsuki Mochizuki, Miyuki Kimura, Shunji Matsuki, Shin Irie, Nobuaki Watanabe, Yukio Kato, Ichiro Ieiri, Kazuya Maeda, Osamu Ando and Hiroyuki Kusuhara
    Drug Metabolism and Disposition November 2019, 47 (11) 1270-1280; DOI: https://doi.org/10.1124/dmd.119.087262
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    Glutathione Conjugation and Protein Adduction Derived from Oxidative Debromination of Benzbromarone in Mice
    Hui Wang, Wenbao Wang, Bowen Gong, Zedan Wang, Yukun Feng, Weige Zhang, Shaojie Wang, Ying Peng and Jiang Zheng
    Drug Metabolism and Disposition November 2019, 47 (11) 1281-1290; DOI: https://doi.org/10.1124/dmd.119.087460
  • Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban
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    Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban
    Eleanor Jing Yi Cheong, Denise Wun Xi Teo, Denise Xin Yi Chua and Eric Chun Yong Chan
    Drug Metabolism and Disposition November 2019, 47 (11) 1291-1306; DOI: https://doi.org/10.1124/dmd.119.086918
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    Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats
    Jae H. Chang, Yi-Chen Chen, Jonathan Cheong, Robert S. Jones and Jodie Pang
    Drug Metabolism and Disposition November 2019, 47 (11) 1307-1313; DOI: https://doi.org/10.1124/dmd.119.088278
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    Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability
    Stephanie E. Martinez, Jian Shi, Hao-Jie Zhu, Tania E. Perez Jimenez, Zhaohui Zhu and Michael H. Court
    Drug Metabolism and Disposition November 2019, 47 (11) 1314-1324; DOI: https://doi.org/10.1124/dmd.119.088070
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    A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach
    Mostafa I. Fekry, Yi Xiao, Jeannette Zinggeler Berg and F. Peter Guengerich
    Drug Metabolism and Disposition November 2019, 47 (11) 1325-1332; DOI: https://doi.org/10.1124/dmd.119.089086
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    The Molecular Mechanism Regulating Diurnal Rhythm of Flavin-Containing Monooxygenase 5 in Mouse Liver
    Min Chen, Baozhang Guan, Haiman Xu, Fangjun Yu, Tianpeng Zhang and Baojian Wu
    Drug Metabolism and Disposition November 2019, 47 (11) 1333-1342; DOI: https://doi.org/10.1124/dmd.119.088450
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    Glucocorticoids Increase Renal Excretion of Urate in Mice by Downregulating Urate Transporter 1
    Gentao Li, Lifeng Han, Ruicong Ma, Khawar Saeed, Hui Xiong, Curtis D. Klaassen, Yuanfu Lu and Youcai Zhang
    Drug Metabolism and Disposition November 2019, 47 (11) 1343-1351; DOI: https://doi.org/10.1124/dmd.119.087700
  • Development of a Gold Nanoparticle–Functionalized Surface Plasmon Resonance Assay for the Sensitive Detection of Monoclonal Antibodies and Its Application in Pharmacokinetics
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    Development of a Gold Nanoparticle–Functionalized Surface Plasmon Resonance Assay for the Sensitive Detection of Monoclonal Antibodies and Its Application in Pharmacokinetics
    Haihong Bai, Mei Yuan, Xiaojing Wang, Xinghe Wang and Jinjing Che
    Drug Metabolism and Disposition November 2019, 47 (11) 1361-1367; DOI: https://doi.org/10.1124/dmd.119.086249

Short Communication

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    Enhanced and Persistent Inhibition of Organic Cation Transporter 1 Activity by Preincubation of Cyclosporine A
    Erika Panfen, Weiqi Chen, Yueping Zhang, Michael Sinz, Punit Marathe, Jinping Gan and Hong Shen
    Drug Metabolism and Disposition November 2019, 47 (11) 1352-1360; DOI: https://doi.org/10.1124/dmd.119.087197
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In this issue

Drug Metabolism and Disposition: 47 (11)
Drug Metabolism and Disposition
Vol. 47, Issue 11
1 Nov 2019
  • Table of Contents
  • Table of Contents (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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