Table of Contents

Articles

• You have access

  In Vitro–In Vivo Inaccuracy: The CYP3A4 Anomaly

  Christine M. Bowman and Leslie Z. Benet

  Drug Metabolism and Disposition December 2019, 47 (12) 1368-1371; DOI: https://doi.org/10.1124/dmd.119.088427
• You have access

  Ginsenoside Rc Is a New Selective UGT1A9 Inhibitor in Human Liver Microsomes and Recombinant Human UGT Isoforms

  Hyunyoung Lee, Jae-Kyung Heo, Ga-Hyun Lee, So-Young Park, Su-Nyeong Jang, Hyun-Ji Kim, Mi Jeong Kwon, Im-Sook Song and Kwang-Hyeon Liu

  Drug Metabolism and Disposition December 2019, 47 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.119.087965
• You have access

  An Accurate In Vitro Prediction of Human VD_ss Based on the Øie–Tozer Equation and Primary Physicochemical Descriptors. 3. Analysis and Assessment of Predictivity on a Large Dataset

  Giuliano Berellini and Franco Lombardo

  Drug Metabolism and Disposition December 2019, 47 (12) 1380-1387; DOI: https://doi.org/10.1124/dmd.119.088914
• You have access

  Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL

  Shannon Kozlovich, Gang Chen, Christy J.W. Watson, William J. Blot and Philip Lazarus

  Drug Metabolism and Disposition December 2019, 47 (12) 1388-1396; DOI: https://doi.org/10.1124/dmd.119.088351
• You have access

  Protein Binding and Hepatic Clearance: Re-Examining the Discrimination between Models of Hepatic Clearance with Diazepam in the Isolated Perfused Rat Liver Preparation

  Hong-Jaan Wang and Leslie Z. Benet

  Drug Metabolism and Disposition December 2019, 47 (12) 1397-1402; DOI: https://doi.org/10.1124/dmd.119.088872
• You have access

  Brain Distributional Kinetics of a Novel MDM2 Inhibitor SAR405838: Implications for Use in Brain Tumor Therapy

  Minjee Kim, Janice K. Laramy, Gautham Gampa, Karen E. Parrish, Richard Brundage, Jann N. Sarkaria and William F. Elmquist

  Drug Metabolism and Disposition December 2019, 47 (12) 1403-1414; DOI: https://doi.org/10.1124/dmd.119.088716
• Open Access

  Pregnancy and CYP3A5 Genotype Affect Day 7 Plasma Lumefantrine Concentrations

  Ritah F. Mutagonda, Omary M.S. Minzi, Siriel N. Massawe, Muhammad Asghar, Anna Färnert, Appolinary A.R. Kamuhabwa and Eleni Aklillu

  Drug Metabolism and Disposition December 2019, 47 (12) 1415-1424; DOI: https://doi.org/10.1124/dmd.119.088062
• You have access

  CYP2D1 Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats

  Hongqiu Zhou, Li Yang, Changsuo Wang, Zhiqiang Li, Zhen Ouyang, Mangting Shan, Jun Gu and Yuan Wei

  Drug Metabolism and Disposition December 2019, 47 (12) 1425-1432; DOI: https://doi.org/10.1124/dmd.119.088526
• You have access

  Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo

  Congrong Niu, Yujin Wang, Xiaofeng Zhao, Sam Tep, Eisuke Murakami, Raju Subramanian, Bill Smith and Yurong Lai

  Drug Metabolism and Disposition December 2019, 47 (12) 1433-1442; DOI: https://doi.org/10.1124/dmd.119.088922
• Open Access

  An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects

  Andrew W. Harrell, Robert Wilson, Yau Lun Man, Kylie Riddell, Emily Jarvis, Graeme Young, Robert Chambers, Lee Crossman, Alex Georgiou, Adrian Pereira, David Kenworthy, Claire Beaumont, Miriam Marotti, Denisa Wilkes, Edith M. Hessel and William A. Fahy

  Drug Metabolism and Disposition December 2019, 47 (12) 1457-1468; DOI: https://doi.org/10.1124/dmd.119.088344
• You have access

  Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using Cyp2abfgs-Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity

  Nataliia Kovalchuk, Qing-Yu Zhang, Jacklyn Kelty, Laura Van Winkle and Xinxin Ding

  Drug Metabolism and Disposition December 2019, 47 (12) 1469-1478; DOI: https://doi.org/10.1124/dmd.119.088930