Research ArticleArticle
Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers
Chun Yang, Dongmei Zhou, Zancong Shen, David M. Wilson, Matthew Renner, Jeffrey N. Miner, Jean-Luc Girardet and Caroline A. Lee
Drug Metabolism and Disposition February 2019, 47 (2) 104-113; DOI: https://doi.org/10.1124/dmd.118.080549
Chun Yang
Preclinical and Clinical DMPK (C.Y., Z.S., C.A.L.), Bioanalytical (D.Z., D.M.W.), Biology (J.N.M.), and Chemistry (M.R., J.-L.G.) Departments, Ardea Biosciences, Inc., San Diego, California
Dongmei Zhou
Preclinical and Clinical DMPK (C.Y., Z.S., C.A.L.), Bioanalytical (D.Z., D.M.W.), Biology (J.N.M.), and Chemistry (M.R., J.-L.G.) Departments, Ardea Biosciences, Inc., San Diego, California
Zancong Shen
Preclinical and Clinical DMPK (C.Y., Z.S., C.A.L.), Bioanalytical (D.Z., D.M.W.), Biology (J.N.M.), and Chemistry (M.R., J.-L.G.) Departments, Ardea Biosciences, Inc., San Diego, California
David M. Wilson
Preclinical and Clinical DMPK (C.Y., Z.S., C.A.L.), Bioanalytical (D.Z., D.M.W.), Biology (J.N.M.), and Chemistry (M.R., J.-L.G.) Departments, Ardea Biosciences, Inc., San Diego, California
Matthew Renner
Preclinical and Clinical DMPK (C.Y., Z.S., C.A.L.), Bioanalytical (D.Z., D.M.W.), Biology (J.N.M.), and Chemistry (M.R., J.-L.G.) Departments, Ardea Biosciences, Inc., San Diego, California
Jeffrey N. Miner
Preclinical and Clinical DMPK (C.Y., Z.S., C.A.L.), Bioanalytical (D.Z., D.M.W.), Biology (J.N.M.), and Chemistry (M.R., J.-L.G.) Departments, Ardea Biosciences, Inc., San Diego, California
Jean-Luc Girardet
Preclinical and Clinical DMPK (C.Y., Z.S., C.A.L.), Bioanalytical (D.Z., D.M.W.), Biology (J.N.M.), and Chemistry (M.R., J.-L.G.) Departments, Ardea Biosciences, Inc., San Diego, California
Caroline A. Lee
Preclinical and Clinical DMPK (C.Y., Z.S., C.A.L.), Bioanalytical (D.Z., D.M.W.), Biology (J.N.M.), and Chemistry (M.R., J.-L.G.) Departments, Ardea Biosciences, Inc., San Diego, California
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Research ArticleArticle
Lesinurad Atropisomer Characterization
Chun Yang, Dongmei Zhou, Zancong Shen, David M. Wilson, Matthew Renner, Jeffrey N. Miner, Jean-Luc Girardet and Caroline A. Lee
Drug Metabolism and Disposition February 1, 2019, 47 (2) 104-113; DOI: https://doi.org/10.1124/dmd.118.080549
Research ArticleArticle
Lesinurad Atropisomer Characterization
Chun Yang, Dongmei Zhou, Zancong Shen, David M. Wilson, Matthew Renner, Jeffrey N. Miner, Jean-Luc Girardet and Caroline A. Lee
Drug Metabolism and Disposition February 1, 2019, 47 (2) 104-113; DOI: https://doi.org/10.1124/dmd.118.080549
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