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Research ArticleArticle

Overcoming P-Glycoprotein–Mediated Drug Resistance with Noscapine Derivatives

Divya Muthiah, Georgia K. Henshaw, Aaron J. DeBono, Ben Capuano, Peter J. Scammells and Richard Callaghan
Drug Metabolism and Disposition February 2019, 47 (2) 164-172; DOI: https://doi.org/10.1124/dmd.118.083188
Divya Muthiah
Division of Biomedical Science and Biochemistry, Research School of Biology and Medical School, Australian National University, Canberra, Australian Capital Territory (D.M., G.K.H., R.C.), and Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria (A.J.D., B.C., P.J.S.), Australia
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Georgia K. Henshaw
Division of Biomedical Science and Biochemistry, Research School of Biology and Medical School, Australian National University, Canberra, Australian Capital Territory (D.M., G.K.H., R.C.), and Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria (A.J.D., B.C., P.J.S.), Australia
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Aaron J. DeBono
Division of Biomedical Science and Biochemistry, Research School of Biology and Medical School, Australian National University, Canberra, Australian Capital Territory (D.M., G.K.H., R.C.), and Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria (A.J.D., B.C., P.J.S.), Australia
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Ben Capuano
Division of Biomedical Science and Biochemistry, Research School of Biology and Medical School, Australian National University, Canberra, Australian Capital Territory (D.M., G.K.H., R.C.), and Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria (A.J.D., B.C., P.J.S.), Australia
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Peter J. Scammells
Division of Biomedical Science and Biochemistry, Research School of Biology and Medical School, Australian National University, Canberra, Australian Capital Territory (D.M., G.K.H., R.C.), and Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria (A.J.D., B.C., P.J.S.), Australia
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Richard Callaghan
Division of Biomedical Science and Biochemistry, Research School of Biology and Medical School, Australian National University, Canberra, Australian Capital Territory (D.M., G.K.H., R.C.), and Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria (A.J.D., B.C., P.J.S.), Australia
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Article Information

vol. 47 no. 2 164-172
DOI 
https://doi.org/10.1124/dmd.118.083188
PubMed 
30478158

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 20, 2018
  • Accepted November 20, 2018
  • Published online January 16, 2019.

Article Versions

  • Earlier version (November 26, 2018 - 05:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Divya Muthiah,
  2. Georgia K. Henshaw,
  3. Aaron J. DeBono,
  4. Ben Capuano,
  5. Peter J. Scammells, and
  6. Richard Callaghan
  1. Division of Biomedical Science and Biochemistry, Research School of Biology and Medical School, Australian National University, Canberra, Australian Capital Territory (D.M., G.K.H., R.C.), and Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria (A.J.D., B.C., P.J.S.), Australia
  1. Address correspondence to:
    Richard Callaghan, Research School of Biology, Building 134, Linnaeus Way, Australian National University, Acton, Canberra, ACT 2601, Australia. E-mail: richard.callaghan{at}anu.edu.au
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Drug Metabolism and Disposition: 47 (2)
Drug Metabolism and Disposition
Vol. 47, Issue 2
1 Feb 2019
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Research ArticleArticle

Inhibition of P-Glycoprotein by Noscapine Derivatives

Divya Muthiah, Georgia K. Henshaw, Aaron J. DeBono, Ben Capuano, Peter J. Scammells and Richard Callaghan
Drug Metabolism and Disposition February 1, 2019, 47 (2) 164-172; DOI: https://doi.org/10.1124/dmd.118.083188

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Research ArticleArticle

Inhibition of P-Glycoprotein by Noscapine Derivatives

Divya Muthiah, Georgia K. Henshaw, Aaron J. DeBono, Ben Capuano, Peter J. Scammells and Richard Callaghan
Drug Metabolism and Disposition February 1, 2019, 47 (2) 164-172; DOI: https://doi.org/10.1124/dmd.118.083188
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