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Identification of 19-(S/R)Hydroxyeicosatetraenoic Acid as the First Endogenous Noncompetitive Inhibitor of Cytochrome P450 1B1 with Enantioselective Activity

Sherif M. Shoieb, Ahmed A. El-Sherbeni and Ayman O. S. El-Kadi
Drug Metabolism and Disposition February 2019, 47 (2) 67-70; DOI: https://doi.org/10.1124/dmd.118.084657

Article Information

vol. 47 no. 2 67-70
DOI 
https://doi.org/10.1124/dmd.118.084657
PubMed 
30420405
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 24, 2018
  • Accepted November 8, 2018
  • Published online January 3, 2019.

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Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sherif M. Shoieb,
  2. Ahmed A. El-Sherbeni, and
  3. Ayman O. S. El-Kadi
  1. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada (S.M.S., A.O.S.E.-K.); Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (A.A.E.-S.); and Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, Egypt (A.A.E.-S.)
  1. Address correspondence to:
    Dr. Ayman O. S. El-Kadi, Faculty of Pharmacy and Pharmaceutical Sciences, 2142J Katz Group-Rexall Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, Canada T6G 2E1. E-mail: aelkadi{at}ualberta.ca
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Rapid CommunicationShort Communication

19-HETE Enantiomers Noncompetitively Inhibit CYP1B1

Sherif M. Shoieb, Ahmed A. El-Sherbeni and Ayman O. S. El-Kadi
Drug Metabolism and Disposition February 1, 2019, 47 (2) 67-70; DOI: https://doi.org/10.1124/dmd.118.084657
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