Research ArticleArticle
Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs with High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the “Albumin-Mediated” Hepatic Uptake Mechanism on the Basis of the “Facilitated-Dissociation Model”
Soo-Jin Kim, Kyeong-Ryoon Lee, Seiji Miyauchi and Yuichi Sugiyama
Drug Metabolism and Disposition February 2019, 47 (2) 94-103; DOI: https://doi.org/10.1124/dmd.118.083733
Soo-Jin Kim
Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Tsurumi-ku, Yokohama, Japan (S.-J.K., K.-R.L., Y.S.); Life Science Institute, Daewoong Pharmaceutical, Pogok-eup, Cheoin-gu, Yongin, Korea (K.-R.L.); and Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan (S.M.)
Kyeong-Ryoon Lee
Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Tsurumi-ku, Yokohama, Japan (S.-J.K., K.-R.L., Y.S.); Life Science Institute, Daewoong Pharmaceutical, Pogok-eup, Cheoin-gu, Yongin, Korea (K.-R.L.); and Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan (S.M.)
Seiji Miyauchi
Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Tsurumi-ku, Yokohama, Japan (S.-J.K., K.-R.L., Y.S.); Life Science Institute, Daewoong Pharmaceutical, Pogok-eup, Cheoin-gu, Yongin, Korea (K.-R.L.); and Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan (S.M.)
Yuichi Sugiyama
Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Tsurumi-ku, Yokohama, Japan (S.-J.K., K.-R.L., Y.S.); Life Science Institute, Daewoong Pharmaceutical, Pogok-eup, Cheoin-gu, Yongin, Korea (K.-R.L.); and Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan (S.M.)
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IVIVE for “Albumin-Mediated” Hepatic Uptake Clearance
Soo-Jin Kim, Kyeong-Ryoon Lee, Seiji Miyauchi and Yuichi Sugiyama
Drug Metabolism and Disposition February 1, 2019, 47 (2) 94-103; DOI: https://doi.org/10.1124/dmd.118.083733
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