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Drug Metabolism & Disposition

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Table of Contents

March 01, 2019; Volume 47,Issue 3

Commentary

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    Ontogeny of ADME Processes during Postnatal Development in Man and Preclinical Species: A Comprehensive Review
    Luc M. De Schaepdrijver, Pieter P. J. Annaert and Connie L. Chen
    Drug Metabolism and Disposition March 2019, 47 (3) 295; DOI: https://doi.org/10.1124/dmd.118.084350

Minireview

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    Physiology of the Neonatal Gastrointestinal System Relevant to the Disposition of Orally Administered Medications
    April Neal-Kluever, Jeffrey Fisher, Lawrence Grylack, Satoko Kakiuchi-Kiyota and Wendy Halpern
    Drug Metabolism and Disposition March 2019, 47 (3) 296-313; DOI: https://doi.org/10.1124/dmd.118.084418

Articles

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    In Silico Prediction of the Absorption and Disposition of Cefadroxil in Humans using an Intestinal Permeability Method Scaled from Humanized PepT1 Mice
    Yongjun Hu and David E. Smith
    Drug Metabolism and Disposition March 2019, 47 (3) 173-183; DOI: https://doi.org/10.1124/dmd.118.084236
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    Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites
    Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang, John Richard Lee, Jimmy Orjala, Hyunwoo Lee and Hyunyoung Jeong
    Drug Metabolism and Disposition March 2019, 47 (3) 194-202; DOI: https://doi.org/10.1124/dmd.118.084772
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    Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Determine the Disposition of Esculetin-7-O-Glucuronide and 4-Methylesculetin-7-O-Glucuronide
    Yuhuan Li, Wenjie Song, Xiaojun Ou, Guangkuo Luo, Yushan Xie, Rongjin Sun, Ying Wang, Xiaoxiao Qi, Ming Hu, Zhongqiu Liu and Lijun Zhu
    Drug Metabolism and Disposition March 2019, 47 (3) 203-214; DOI: https://doi.org/10.1124/dmd.118.083493
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    Hepatic Organic Anion Transporting Polypeptide–Mediated Clearance in the Beagle Dog: Assessing In Vitro–In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance
    Norikazu Matsunaga, Ayşe Ufuk, Bridget L. Morse, David W. Bedwell, Jingqi Bao, Michael A. Mohutsky, Kathleen M. Hillgren, Stephen D. Hall, J. Brian Houston and Aleksandra Galetin
    Drug Metabolism and Disposition March 2019, 47 (3) 215-226; DOI: https://doi.org/10.1124/dmd.118.084194
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    Characterization of Anacetrapib Distribution into the Lipid Droplet of Adipose Tissue in Mice and Human Cultured Adipocytes
    Douglas G. Johns, Lauretta LeVoci, Mihajlo Krsmanovic, Min Lu, Georgy Hartmann, Suoyu Xu, Sheng-Ping Wang, Ying Chen, Thomas Bateman and Robert O. Blaustein
    Drug Metabolism and Disposition March 2019, 47 (3) 227-233; DOI: https://doi.org/10.1124/dmd.118.084525
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    Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases
    Fandi Kong, Xiaoyan Pang, Jihui Zhao, Pan Deng, Mingyue Zheng, Dafang Zhong and Xiaoyan Chen
    Drug Metabolism and Disposition March 2019, 47 (3) 238-248; DOI: https://doi.org/10.1124/dmd.118.084640
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    Hepatic Enzymes Relevant to the Disposition of (−)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC
    Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat
    Drug Metabolism and Disposition March 2019, 47 (3) 249-256; DOI: https://doi.org/10.1124/dmd.118.085548
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    Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics
    Dominique A. Ramirez, Keagan P. Collins, Allister E. Aradi, Katherine A. Conger and Daniel L. Gustafson
    Drug Metabolism and Disposition March 2019, 47 (3) 257-268; DOI: https://doi.org/10.1124/dmd.118.083766
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    Drug and Chemical Glucosidation by Control Supersomes and Membranes from Spodoptera frugiperda (Sf) 9 Cells: Implications for the Apparent Glucuronidation of Xenobiotics by UDP-glucuronosyltransferase 1A5
    Nuy Chau, Leyla Kaya, Benjamin C. Lewis, Peter I. Mackenzie and John O. Miners
    Drug Metabolism and Disposition March 2019, 47 (3) 271-278; DOI: https://doi.org/10.1124/dmd.118.084947
  • Continuum of Host-Gut Microbial Co-metabolism: Host CYP3A4/3A7 are Responsible for Tertiary Oxidations of Deoxycholate Species
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    Continuum of Host-Gut Microbial Co-metabolism: Host CYP3A4/3A7 are Responsible for Tertiary Oxidations of Deoxycholate Species
    Jian Zhang, Ling-Zhi Gao, Yu-Jie Chen, Ping-Ping Zhu, Shan-Shan Yin, Ming-Ming Su, Yan Ni, Jia Miao, Wen-Lin Wu, Hong Chen, Kim L. R. Brouwer, Chang-Xiao Liu, Liang Xu, Wei Jia and Ke Lan
    Drug Metabolism and Disposition March 2019, 47 (3) 283-294; DOI: https://doi.org/10.1124/dmd.118.085670
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    Use of Segregated Hepatocyte Scaling Factors and Cross-Species Relationships to Resolve Clearance Dependence in the Prediction of Human Hepatic Clearance
    D. Hallifax and J.B. Houston
    Drug Metabolism and Disposition March 2019, 47 (3) 320-327; DOI: https://doi.org/10.1124/dmd.118.085191
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    Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver
    Joseph L. Dempsey and Julia Yue Cui
    Drug Metabolism and Disposition March 2019, 47 (3) 329-339; DOI: https://doi.org/10.1124/dmd.118.085142
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    Pharmacokinetics, Metabolism, and Excretion of [14C]Esaxerenone, a Novel Mineralocorticoid Receptor Blocker in Humans
    Makiko Yamada, Jeanne Mendell, Hideo Takakusa, Takako Shimizu and Osamu Ando
    Drug Metabolism and Disposition March 2019, 47 (3) 340-349; DOI: https://doi.org/10.1124/dmd.118.084897

Short Communication

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    A Recombinant Humanized Anticocaine Monoclonal Antibody Alters the Urinary Clearance of Cocaine and Its Metabolites in Rats
    Jordan A. Marckel, Hanna N. Wetzel, Sihame Amlal, Hassane Amlal and Andrew B. Norman
    Drug Metabolism and Disposition March 2019, 47 (3) 184-188; DOI: https://doi.org/10.1124/dmd.118.083857
  • Gas-Phase Rearrangement of the <em>O</em>-Glucuronide of Vildagliptin Forms Product-Ion Fragments Suggesting Wrongly an <em>N</em>-Glucuronide
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    Gas-Phase Rearrangement of the O-Glucuronide of Vildagliptin Forms Product-Ion Fragments Suggesting Wrongly an N-Glucuronide
    Andreas Fredenhagen, Jürgen Kühnöl, Matthias Kittelmann and Lukas Oberer
    Drug Metabolism and Disposition March 2019, 47 (3) 189-193; DOI: https://doi.org/10.1124/dmd.118.085597
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    Age Dependency of Blood-Brain Barrier Penetration by cis- and trans-Permethrin in the Rat
    Tanzir B. Mortuza, Gaylen L. Edwards, Catherine A. White, Vandan Patel, Brian S. Cummings and James V. Bruckner
    Drug Metabolism and Disposition March 2019, 47 (3) 234-237; DOI: https://doi.org/10.1124/dmd.118.084822
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    Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice
    Michael Crosby and David S. Riddick
    Drug Metabolism and Disposition March 2019, 47 (3) 279-282; DOI: https://doi.org/10.1124/dmd.118.084509
  • The MBNL/CELF Splicing Factors Regulate Cytosolic Sulfotransferase 4A1 Protein Expression during Cell Differentiation
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    The MBNL/CELF Splicing Factors Regulate Cytosolic Sulfotransferase 4A1 Protein Expression during Cell Differentiation
    Misgana Idris, Neville J. Butcher and Rodney F. Minchin
    Drug Metabolism and Disposition March 2019, 47 (3) 314-319; DOI: https://doi.org/10.1124/dmd.118.085290

Errata

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    Correction to “A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects”
    Drug Metabolism and Disposition March 2019, 47 (3) 269; DOI: https://doi.org/10.1124/dmd.117.078790err2
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    Correction to “Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent CYP1A1 Induction”
    Drug Metabolism and Disposition March 2019, 47 (3) 270; DOI: https://doi.org/10.1124/dmd.117.082164err
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    Correction to “Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease”
    Drug Metabolism and Disposition March 2019, 47 (3) 328; DOI: https://doi.org/10.1124/dmd.115.083907err
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In this issue

Drug Metabolism and Disposition: 47 (3)
Drug Metabolism and Disposition
Vol. 47, Issue 3
1 Mar 2019
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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