Table of Contents

Articles

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  In Silico Prediction of the Absorption and Disposition of Cefadroxil in Humans using an Intestinal Permeability Method Scaled from Humanized PepT1 Mice

  Yongjun Hu and David E. Smith

  Drug Metabolism and Disposition March 2019, 47 (3) 173-183; DOI: https://doi.org/10.1124/dmd.118.084236
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  Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites

  Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang, John Richard Lee, Jimmy Orjala, Hyunwoo Lee and Hyunyoung Jeong

  Drug Metabolism and Disposition March 2019, 47 (3) 194-202; DOI: https://doi.org/10.1124/dmd.118.084772
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  Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Determine the Disposition of Esculetin-7-O-Glucuronide and 4-Methylesculetin-7-O-Glucuronide

  Yuhuan Li, Wenjie Song, Xiaojun Ou, Guangkuo Luo, Yushan Xie, Rongjin Sun, Ying Wang, Xiaoxiao Qi, Ming Hu, Zhongqiu Liu and Lijun Zhu

  Drug Metabolism and Disposition March 2019, 47 (3) 203-214; DOI: https://doi.org/10.1124/dmd.118.083493
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  Hepatic Organic Anion Transporting Polypeptide–Mediated Clearance in the Beagle Dog: Assessing In Vitro–In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance

  Norikazu Matsunaga, Ayşe Ufuk, Bridget L. Morse, David W. Bedwell, Jingqi Bao, Michael A. Mohutsky, Kathleen M. Hillgren, Stephen D. Hall, J. Brian Houston and Aleksandra Galetin

  Drug Metabolism and Disposition March 2019, 47 (3) 215-226; DOI: https://doi.org/10.1124/dmd.118.084194
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  Characterization of Anacetrapib Distribution into the Lipid Droplet of Adipose Tissue in Mice and Human Cultured Adipocytes

  Douglas G. Johns, Lauretta LeVoci, Mihajlo Krsmanovic, Min Lu, Georgy Hartmann, Suoyu Xu, Sheng-Ping Wang, Ying Chen, Thomas Bateman and Robert O. Blaustein

  Drug Metabolism and Disposition March 2019, 47 (3) 227-233; DOI: https://doi.org/10.1124/dmd.118.084525
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  Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases

  Fandi Kong, Xiaoyan Pang, Jihui Zhao, Pan Deng, Mingyue Zheng, Dafang Zhong and Xiaoyan Chen

  Drug Metabolism and Disposition March 2019, 47 (3) 238-248; DOI: https://doi.org/10.1124/dmd.118.084640
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  Hepatic Enzymes Relevant to the Disposition of (−)-∆⁹-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC

  Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat

  Drug Metabolism and Disposition March 2019, 47 (3) 249-256; DOI: https://doi.org/10.1124/dmd.118.085548
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  Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics

  Dominique A. Ramirez, Keagan P. Collins, Allister E. Aradi, Katherine A. Conger and Daniel L. Gustafson

  Drug Metabolism and Disposition March 2019, 47 (3) 257-268; DOI: https://doi.org/10.1124/dmd.118.083766
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  Drug and Chemical Glucosidation by Control Supersomes and Membranes from Spodoptera frugiperda (Sf) 9 Cells: Implications for the Apparent Glucuronidation of Xenobiotics by UDP-glucuronosyltransferase 1A5

  Nuy Chau, Leyla Kaya, Benjamin C. Lewis, Peter I. Mackenzie and John O. Miners

  Drug Metabolism and Disposition March 2019, 47 (3) 271-278; DOI: https://doi.org/10.1124/dmd.118.084947
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  Continuum of Host-Gut Microbial Co-metabolism: Host CYP3A4/3A7 are Responsible for Tertiary Oxidations of Deoxycholate Species

  Jian Zhang, Ling-Zhi Gao, Yu-Jie Chen, Ping-Ping Zhu, Shan-Shan Yin, Ming-Ming Su, Yan Ni, Jia Miao, Wen-Lin Wu, Hong Chen, Kim L. R. Brouwer, Chang-Xiao Liu, Liang Xu, Wei Jia and Ke Lan

  Drug Metabolism and Disposition March 2019, 47 (3) 283-294; DOI: https://doi.org/10.1124/dmd.118.085670
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  Use of Segregated Hepatocyte Scaling Factors and Cross-Species Relationships to Resolve Clearance Dependence in the Prediction of Human Hepatic Clearance

  D. Hallifax and J.B. Houston

  Drug Metabolism and Disposition March 2019, 47 (3) 320-327; DOI: https://doi.org/10.1124/dmd.118.085191
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  Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver

  Joseph L. Dempsey and Julia Yue Cui

  Drug Metabolism and Disposition March 2019, 47 (3) 329-339; DOI: https://doi.org/10.1124/dmd.118.085142
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  Pharmacokinetics, Metabolism, and Excretion of [¹⁴C]Esaxerenone, a Novel Mineralocorticoid Receptor Blocker in Humans

  Makiko Yamada, Jeanne Mendell, Hideo Takakusa, Takako Shimizu and Osamu Ando

  Drug Metabolism and Disposition March 2019, 47 (3) 340-349; DOI: https://doi.org/10.1124/dmd.118.084897