Research ArticleArticle
Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites
Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang, John Richard Lee, Jimmy Orjala, Hyunwoo Lee and Hyunyoung Jeong
Drug Metabolism and Disposition March 2019, 47 (3) 194-202; DOI: https://doi.org/10.1124/dmd.118.084772
Yukuang Guo
Departments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)
Camila Manoel Crnkovic
Departments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)
Kyoung-Jae Won
Departments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)
Xiaotong Yang
Departments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)
John Richard Lee
Departments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)
Jimmy Orjala
Departments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)
Hyunwoo Lee
Departments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)
Hyunyoung Jeong
Departments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)

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Research ArticleArticle
Tacrolimus Metabolism by Gut Bacteria
Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang, John Richard Lee, Jimmy Orjala, Hyunwoo Lee and Hyunyoung Jeong
Drug Metabolism and Disposition March 1, 2019, 47 (3) 194-202; DOI: https://doi.org/10.1124/dmd.118.084772
Research ArticleArticle
Tacrolimus Metabolism by Gut Bacteria
Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang, John Richard Lee, Jimmy Orjala, Hyunwoo Lee and Hyunyoung Jeong
Drug Metabolism and Disposition March 1, 2019, 47 (3) 194-202; DOI: https://doi.org/10.1124/dmd.118.084772
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