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Drug Metabolism & Disposition

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Table of Contents

April 01, 2019; Volume 47,Issue 4

Articles

  • You have access
    A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
    Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
    Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988
  • You have access
    The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation
    Christine M. Bowman, Hideaki Okochi and Leslie Z. Benet
    Drug Metabolism and Disposition April 2019, 47 (4) 358-363; DOI: https://doi.org/10.1124/dmd.118.085779
  • Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
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    Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
    Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng and Weidong Chen
    Drug Metabolism and Disposition April 2019, 47 (4) 364-376; DOI: https://doi.org/10.1124/dmd.118.085340
  • Open Access
    Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans
    Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
    Drug Metabolism and Disposition April 2019, 47 (4) 377-385; DOI: https://doi.org/10.1124/dmd.118.084665
  • Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
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    Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
    Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto and Katsuhisa Inoue
    Drug Metabolism and Disposition April 2019, 47 (4) 386-391; DOI: https://doi.org/10.1124/dmd.118.084483
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    Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice
    Minjee Kim, Janice K. Laramy, Afroz S. Mohammad, Surabhi Talele, James Fisher, Jann N. Sarkaria and William F. Elmquist
    Drug Metabolism and Disposition April 2019, 47 (4) 393-404; DOI: https://doi.org/10.1124/dmd.118.084210
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    In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
    Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
    Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279
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    Hepatocyte Concentrations of Imaging Compounds Associated with Transporter Inhibition: Evidence in Perfused Rat Livers
    Pierre Bonnaventure, Fabien Cusin and Catherine M. Pastor
    Drug Metabolism and Disposition April 2019, 47 (4) 412-418; DOI: https://doi.org/10.1124/dmd.118.084624
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    Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
    Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
    Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269
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    Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
    Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah and Janne T. Backman
    Drug Metabolism and Disposition April 2019, 47 (4) 436-443; DOI: https://doi.org/10.1124/dmd.118.085498

Short Communication

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    Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate
    John T. Barr, Julie M. Lade, Thuy B. Tran and Upendra P. Dahal
    Drug Metabolism and Disposition April 2019, 47 (4) 419-423; DOI: https://doi.org/10.1124/dmd.118.085936

Errata

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    Correction to “In Vitro Hepatic Oxidative Biotransformation of Trimethoprim”
    Drug Metabolism and Disposition April 2019, 47 (4) 392; DOI: https://doi.org/10.1124/dmd.117.065193err
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    Correction to “Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children”
    Drug Metabolism and Disposition April 2019, 47 (4) 424; DOI: https://doi.org/10.1124/dmd.117.072256err
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Drug Metabolism and Disposition: 47 (4)
Drug Metabolism and Disposition
Vol. 47, Issue 4
1 Apr 2019
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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