Table of Contents

Articles

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  A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation

  Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat

  Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988
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  The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation

  Christine M. Bowman, Hideaki Okochi and Leslie Z. Benet

  Drug Metabolism and Disposition April 2019, 47 (4) 358-363; DOI: https://doi.org/10.1124/dmd.118.085779
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  Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo

  Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng and Weidong Chen

  Drug Metabolism and Disposition April 2019, 47 (4) 364-376; DOI: https://doi.org/10.1124/dmd.118.085340
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  Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans

  Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman

  Drug Metabolism and Disposition April 2019, 47 (4) 377-385; DOI: https://doi.org/10.1124/dmd.118.084665
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  Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats

  Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto and Katsuhisa Inoue

  Drug Metabolism and Disposition April 2019, 47 (4) 386-391; DOI: https://doi.org/10.1124/dmd.118.084483
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  Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice

  Minjee Kim, Janice K. Laramy, Afroz S. Mohammad, Surabhi Talele, James Fisher, Jann N. Sarkaria and William F. Elmquist

  Drug Metabolism and Disposition April 2019, 47 (4) 393-404; DOI: https://doi.org/10.1124/dmd.118.084210
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  In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier

  Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras

  Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279
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  Hepatocyte Concentrations of Imaging Compounds Associated with Transporter Inhibition: Evidence in Perfused Rat Livers

  Pierre Bonnaventure, Fabien Cusin and Catherine M. Pastor

  Drug Metabolism and Disposition April 2019, 47 (4) 412-418; DOI: https://doi.org/10.1124/dmd.118.084624
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  Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19

  Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid

  Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269
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  Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

  Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah and Janne T. Backman

  Drug Metabolism and Disposition April 2019, 47 (4) 436-443; DOI: https://doi.org/10.1124/dmd.118.085498