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Index by author

April 01, 2019; Volume 47,Issue 4

B

  1. Backman, Janne T.

    1. Open Access
      Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 377-385; DOI: https://doi.org/10.1124/dmd.118.084665
    2. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
      Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 436-443; DOI: https://doi.org/10.1124/dmd.118.085498

  2. Barr, John T.

    1. Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate
      John T. Barr, Julie M. Lade, Thuy B. Tran and Upendra P. Dahal
      Drug Metabolism and Disposition April 2019, 47 (4) 419-423; DOI: https://doi.org/10.1124/dmd.118.085936

  3. Benet, Leslie Z.

    1. The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation
      Christine M. Bowman, Hideaki Okochi and Leslie Z. Benet
      Drug Metabolism and Disposition April 2019, 47 (4) 358-363; DOI: https://doi.org/10.1124/dmd.118.085779

  4. Bielinski, Suzette J.

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

  5. Black, John L.

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

  6. Bonnaventure, Pierre

    1. Hepatocyte Concentrations of Imaging Compounds Associated with Transporter Inhibition: Evidence in Perfused Rat Livers
      Pierre Bonnaventure, Fabien Cusin and Catherine M. Pastor
      Drug Metabolism and Disposition April 2019, 47 (4) 412-418; DOI: https://doi.org/10.1124/dmd.118.084624

  7. Bowman, Christine M.

    1. The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation
      Christine M. Bowman, Hideaki Okochi and Leslie Z. Benet
      Drug Metabolism and Disposition April 2019, 47 (4) 358-363; DOI: https://doi.org/10.1124/dmd.118.085779

C

  1. Carlo, Anthony A.

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

  2. Chen, Weidong

    1. Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng and Weidong Chen
      Drug Metabolism and Disposition April 2019, 47 (4) 364-376; DOI: https://doi.org/10.1124/dmd.118.085340

  3. Chu, Xiaoyan

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

  4. Cusin, Fabien

    1. Hepatocyte Concentrations of Imaging Compounds Associated with Transporter Inhibition: Evidence in Perfused Rat Livers
      Pierre Bonnaventure, Fabien Cusin and Catherine M. Pastor
      Drug Metabolism and Disposition April 2019, 47 (4) 412-418; DOI: https://doi.org/10.1124/dmd.118.084624

D

  1. Dahal, Upendra P.

    1. Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate
      John T. Barr, Julie M. Lade, Thuy B. Tran and Upendra P. Dahal
      Drug Metabolism and Disposition April 2019, 47 (4) 419-423; DOI: https://doi.org/10.1124/dmd.118.085936

  2. Devarajan, Sandhya

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

E

  1. Elmquist, William F.

    1. Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice
      Minjee Kim, Janice K. Laramy, Afroz S. Mohammad, Surabhi Talele, James Fisher, Jann N. Sarkaria and William F. Elmquist
      Drug Metabolism and Disposition April 2019, 47 (4) 393-404; DOI: https://doi.org/10.1124/dmd.118.084210

  2. Evangelista, Eric A.

    1. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
      Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 436-443; DOI: https://doi.org/10.1124/dmd.118.085498

F

  1. Feng, Bo

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

  2. Filppula, Anne M.

    1. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
      Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 436-443; DOI: https://doi.org/10.1124/dmd.118.085498

  3. Fisher, James

    1. Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice
      Minjee Kim, Janice K. Laramy, Afroz S. Mohammad, Surabhi Talele, James Fisher, Jann N. Sarkaria and William F. Elmquist
      Drug Metabolism and Disposition April 2019, 47 (4) 393-404; DOI: https://doi.org/10.1124/dmd.118.084210

  4. Funai, Yuta

    1. Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto and Katsuhisa Inoue
      Drug Metabolism and Disposition April 2019, 47 (4) 386-391; DOI: https://doi.org/10.1124/dmd.118.084483

H

  1. Heyward, Scott

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

  2. Ho, Ming-Fen

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

  3. Hop, Cornelis E. C. A.

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

  4. Humphreys, W. Griffith

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

I

  1. Ichijo, Kazuki

    1. Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto and Katsuhisa Inoue
      Drug Metabolism and Disposition April 2019, 47 (4) 386-391; DOI: https://doi.org/10.1124/dmd.118.084483

  2. Inoue, Katsuhisa

    1. Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto and Katsuhisa Inoue
      Drug Metabolism and Disposition April 2019, 47 (4) 386-391; DOI: https://doi.org/10.1124/dmd.118.084483

  3. Ishihara, Marika

    1. Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto and Katsuhisa Inoue
      Drug Metabolism and Disposition April 2019, 47 (4) 386-391; DOI: https://doi.org/10.1124/dmd.118.084483

  4. Itkonen, Matti K.

    1. Open Access
      Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 377-385; DOI: https://doi.org/10.1124/dmd.118.084665

K

  1. Kahma, Helinä

    1. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
      Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 436-443; DOI: https://doi.org/10.1124/dmd.118.085498

  2. Kim, Minjee

    1. Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice
      Minjee Kim, Janice K. Laramy, Afroz S. Mohammad, Surabhi Talele, James Fisher, Jann N. Sarkaria and William F. Elmquist
      Drug Metabolism and Disposition April 2019, 47 (4) 393-404; DOI: https://doi.org/10.1124/dmd.118.084210

  3. Kishimoto, Hisanao

    1. Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto and Katsuhisa Inoue
      Drug Metabolism and Disposition April 2019, 47 (4) 386-391; DOI: https://doi.org/10.1124/dmd.118.084483

  4. Kumar, Vineet

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

L

  1. Lade, Julie M.

    1. Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate
      John T. Barr, Julie M. Lade, Thuy B. Tran and Upendra P. Dahal
      Drug Metabolism and Disposition April 2019, 47 (4) 419-423; DOI: https://doi.org/10.1124/dmd.118.085936

  2. Lai, Yurong

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

  3. Laramy, Janice K.

    1. Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice
      Minjee Kim, Janice K. Laramy, Afroz S. Mohammad, Surabhi Talele, James Fisher, Jann N. Sarkaria and William F. Elmquist
      Drug Metabolism and Disposition April 2019, 47 (4) 393-404; DOI: https://doi.org/10.1124/dmd.118.084210

  4. Larson, Nicholas B.

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

  5. Lau, Thomas Y.

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

  6. Launiainen, Terhi

    1. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
      Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 436-443; DOI: https://doi.org/10.1124/dmd.118.085498

  7. Liao, Mingxiang

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

  8. Liras, Jennifer L.

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

M

  1. Mathias, Anita

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

  2. Maurer, Tristan S.

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

  3. Mohammad, Afroz S.

    1. Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice
      Minjee Kim, Janice K. Laramy, Afroz S. Mohammad, Surabhi Talele, James Fisher, Jann N. Sarkaria and William F. Elmquist
      Drug Metabolism and Disposition April 2019, 47 (4) 393-404; DOI: https://doi.org/10.1124/dmd.118.084210

  4. Moon, Irene

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

  5. Moyer, Ann M.

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

N

  1. Neavin, Drew R.

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

  2. Neuvonen, Mikko

    1. Open Access
      Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 377-385; DOI: https://doi.org/10.1124/dmd.118.084665
    2. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
      Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 436-443; DOI: https://doi.org/10.1124/dmd.118.085498

  3. Neuvonen, Pertti J.

    1. Open Access
      Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 377-385; DOI: https://doi.org/10.1124/dmd.118.084665

  4. Niemi, Mikko

    1. Open Access
      Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 377-385; DOI: https://doi.org/10.1124/dmd.118.084665

O

  1. Okochi, Hideaki

    1. The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation
      Christine M. Bowman, Hideaki Okochi and Leslie Z. Benet
      Drug Metabolism and Disposition April 2019, 47 (4) 358-363; DOI: https://doi.org/10.1124/dmd.118.085779

P

  1. Pastor, Catherine M.

    1. Hepatocyte Concentrations of Imaging Compounds Associated with Transporter Inhibition: Evidence in Perfused Rat Livers
      Pierre Bonnaventure, Fabien Cusin and Catherine M. Pastor
      Drug Metabolism and Disposition April 2019, 47 (4) 412-418; DOI: https://doi.org/10.1124/dmd.118.084624

  2. Patel, Nandini C.

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

  3. Peng, Daiyin

    1. Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng and Weidong Chen
      Drug Metabolism and Disposition April 2019, 47 (4) 364-376; DOI: https://doi.org/10.1124/dmd.118.085340

R

  1. Reid, Joel M.

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

S

  1. Salphati, Laurent

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

  2. Sarkaria, Jann N.

    1. Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice
      Minjee Kim, Janice K. Laramy, Afroz S. Mohammad, Surabhi Talele, James Fisher, Jann N. Sarkaria and William F. Elmquist
      Drug Metabolism and Disposition April 2019, 47 (4) 393-404; DOI: https://doi.org/10.1124/dmd.118.084210

  3. Scherer, Steven E.

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

  4. Shirasaka, Yoshiyuki

    1. Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto and Katsuhisa Inoue
      Drug Metabolism and Disposition April 2019, 47 (4) 386-391; DOI: https://doi.org/10.1124/dmd.118.084483

T

  1. Takemura, Miyuki

    1. Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
      Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto and Katsuhisa Inoue
      Drug Metabolism and Disposition April 2019, 47 (4) 386-391; DOI: https://doi.org/10.1124/dmd.118.084483

  2. Talele, Surabhi

    1. Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice
      Minjee Kim, Janice K. Laramy, Afroz S. Mohammad, Surabhi Talele, James Fisher, Jann N. Sarkaria and William F. Elmquist
      Drug Metabolism and Disposition April 2019, 47 (4) 393-404; DOI: https://doi.org/10.1124/dmd.118.084210

  3. Tornio, Aleksi

    1. Open Access
      Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 377-385; DOI: https://doi.org/10.1124/dmd.118.084665

  4. Totah, Rheem A.

    1. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
      Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 436-443; DOI: https://doi.org/10.1124/dmd.118.085498

  5. Tran, Thuy B.

    1. Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate
      John T. Barr, Julie M. Lade, Thuy B. Tran and Upendra P. Dahal
      Drug Metabolism and Disposition April 2019, 47 (4) 419-423; DOI: https://doi.org/10.1124/dmd.118.085936

  6. Trapa, Patrick E.

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

  7. Troutman, Matthew D.

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

U

  1. Umland, John P.

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

  2. Unadkat, Jashvant D.

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

V

  1. Viinamäki, Jenni

    1. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
      Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah and Janne T. Backman
      Drug Metabolism and Disposition April 2019, 47 (4) 436-443; DOI: https://doi.org/10.1124/dmd.118.085498

W

  1. Wager, Travis T.

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

  2. Wang, Fengling

    1. Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng and Weidong Chen
      Drug Metabolism and Disposition April 2019, 47 (4) 364-376; DOI: https://doi.org/10.1124/dmd.118.085340

  3. Wang, Huihui

    1. Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng and Weidong Chen
      Drug Metabolism and Disposition April 2019, 47 (4) 364-376; DOI: https://doi.org/10.1124/dmd.118.085340

  4. Wang, Liewei

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

  5. Weinshilboum, Richard M.

    1. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
      Sandhya Devarajan, Irene Moon, Ming-Fen Ho, Nicholas B. Larson, Drew R. Neavin, Ann M. Moyer, John L. Black, Suzette J. Bielinski, Steven E. Scherer, Liewei Wang, Richard M. Weinshilboum and Joel M. Reid
      Drug Metabolism and Disposition April 2019, 47 (4) 425-435; DOI: https://doi.org/10.1124/dmd.118.084269

  6. West, Mark A.

    1. In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier
      Patrick E. Trapa, Matthew D. Troutman, Thomas Y. Lau, Travis T. Wager, Tristan S. Maurer, Nandini C. Patel, Mark A. West, John P. Umland, Anthony A. Carlo, Bo Feng and Jennifer L. Liras
      Drug Metabolism and Disposition April 2019, 47 (4) 405-411; DOI: https://doi.org/10.1124/dmd.118.083279

  7. Wu, Yifan

    1. Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng and Weidong Chen
      Drug Metabolism and Disposition April 2019, 47 (4) 364-376; DOI: https://doi.org/10.1124/dmd.118.085340

X

  1. Xiao, Guangqing

    1. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation
      Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2019, 47 (4) 350-357; DOI: https://doi.org/10.1124/dmd.118.084988

  2. Xie, Xiaoting

    1. Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng and Weidong Chen
      Drug Metabolism and Disposition April 2019, 47 (4) 364-376; DOI: https://doi.org/10.1124/dmd.118.085340

Y

  1. Ye, Xi

    1. Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng and Weidong Chen
      Drug Metabolism and Disposition April 2019, 47 (4) 364-376; DOI: https://doi.org/10.1124/dmd.118.085340

Z

  1. Zhang, Jiwen

    1. Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
      Fengling Wang, Yifan Wu, Jiwen Zhang, Huihui Wang, Xiaoting Xie, Xi Ye, Daiyin Peng and Weidong Chen
      Drug Metabolism and Disposition April 2019, 47 (4) 364-376; DOI: https://doi.org/10.1124/dmd.118.085340
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