Table of Contents

Articles

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  Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibody

  Jean-Philippe Émond, Adrien Labriet, Sylvie Desjardins, Michèle Rouleau, Lyne Villeneuve, Hélène Hovington, Hervé Brisson, Louis Lacombe, David Simonyan, Patrick Caron, Martine Périgny, Bernard Têtu, John K. Fallon, Kathrin Klein, Philip C. Smith, Ulrich M. Zanger, Chantal Guillemette and Eric Lévesque

  Drug Metabolism and Disposition May 2019, 47 (5) 444-452; DOI: https://doi.org/10.1124/dmd.119.086330
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  Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes

  Ronald de Vries, Frank Jacobs, Geert Mannens, Jan Snoeys, Filip Cuyckens, Caly Chien and Peter Ward

  Drug Metabolism and Disposition May 2019, 47 (5) 453-464; DOI: https://doi.org/10.1124/dmd.118.084517
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  In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites

  Yuli Qian, Xinwen Wang and John S. Markowitz

  Drug Metabolism and Disposition May 2019, 47 (5) 465-472; DOI: https://doi.org/10.1124/dmd.118.086074
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  Time Course of Aldehyde Oxidase and Why It Is Nonlinear

  Armina Abbasi, Erickson M. Paragas, Carolyn A. Joswig-Jones, John T. Rodgers and Jeffrey P. Jones

  Drug Metabolism and Disposition May 2019, 47 (5) 473-483; DOI: https://doi.org/10.1124/dmd.118.085787
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  A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes

  Keith A. Riccardi, David A. Tess, Jian Lin, Roshan Patel, Sangwoo Ryu, Karen Atkinson, Li Di and Rui Li

  Drug Metabolism and Disposition May 2019, 47 (5) 484-492; DOI: https://doi.org/10.1124/dmd.118.085639
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  Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1

  Emi Kimoto, Manoli Vourvahis, Renato J. Scialis, Heather Eng, A. David Rodrigues and Manthena V. S. Varma

  Drug Metabolism and Disposition May 2019, 47 (5) 493-503; DOI: https://doi.org/10.1124/dmd.118.085241
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  Oxidative Deamination of Emixustat by Human Vascular Adhesion Protein-1/Semicarbazide-Sensitive Amine Oxidase

  Michael J. Reid, Russell Eyre and Terry Podoll

  Drug Metabolism and Disposition May 2019, 47 (5) 504-515; DOI: https://doi.org/10.1124/dmd.118.085811
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  Role of ABCG2 in Secretion into Milk of the Anti-Inflammatory Flunixin and Its Main Metabolite: In Vitro-In Vivo Correlation in Mice and Cows

  Dafne Garcia-Mateos, Alba Maria Garcia-Lino, Indira Alvarez-Fernandez, Esther Blanco-Paniagua, Alvaro de la Fuente, Ana Isabel Alvarez and Gracia Merino

  Drug Metabolism and Disposition May 2019, 47 (5) 516-524; DOI: https://doi.org/10.1124/dmd.118.085506
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  Characterization of Fasiglifam-Related Liver Toxicity in Dogs

  Akifumi Kogame, Yuu Moriya, Ikuo Mori, Liping Pan, Akio Morohashi, Takuya Ebihara, Hideo Fukui, Yoshihiko Tagawa and Leslie Z. Benet

  Drug Metabolism and Disposition May 2019, 47 (5) 525-534; DOI: https://doi.org/10.1124/dmd.118.084889
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  Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors

  Stephanie N. Liu, Jessica Bo Li Lu, Christy J. W. Watson, Philip Lazarus, Zeruesenay Desta and Brandon T. Gufford

  Drug Metabolism and Disposition May 2019, 47 (5) 535-544; DOI: https://doi.org/10.1124/dmd.118.085035
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  A Novel Depurination Methodology to Assess DNA Alkylation of Chloro-Bis-Seco-Cyclopropylbenzoindoles Allowed for Comparison of Minor-Groove Reactivity

  Shuai Wang, Buyun Chen, Peter Dragovich, Thomas Pillow, Leanna Staben, Jun Guo, Dian Su, Chenghong Zhang, Sudheer Bobba, Yong Ma, Jianshuang Wang, Dewakar Sangaraju, BinQing Wei, Gail Lewis Phillips, Cyrus Khojasteh and Donglu Zhang

  Drug Metabolism and Disposition May 2019, 47 (5) 547-555; DOI: https://doi.org/10.1124/dmd.118.085209