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Research ArticleArticle

Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes

Ronald de Vries, Frank Jacobs, Geert Mannens, Jan Snoeys, Filip Cuyckens, Caly Chien and Peter Ward
Drug Metabolism and Disposition May 2019, 47 (5) 453-464; DOI: https://doi.org/10.1124/dmd.118.084517
Ronald de Vries
Janssen Research & Development, Beerse, Belgium (R.d.V., F.J., G.M., J.S., F.C.); Janssen Research & Development, Spring House, Pennsylvania (C.C.); and Janssen Research & Development, San Diego, California (P.W.)
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Frank Jacobs
Janssen Research & Development, Beerse, Belgium (R.d.V., F.J., G.M., J.S., F.C.); Janssen Research & Development, Spring House, Pennsylvania (C.C.); and Janssen Research & Development, San Diego, California (P.W.)
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Geert Mannens
Janssen Research & Development, Beerse, Belgium (R.d.V., F.J., G.M., J.S., F.C.); Janssen Research & Development, Spring House, Pennsylvania (C.C.); and Janssen Research & Development, San Diego, California (P.W.)
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Jan Snoeys
Janssen Research & Development, Beerse, Belgium (R.d.V., F.J., G.M., J.S., F.C.); Janssen Research & Development, Spring House, Pennsylvania (C.C.); and Janssen Research & Development, San Diego, California (P.W.)
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Filip Cuyckens
Janssen Research & Development, Beerse, Belgium (R.d.V., F.J., G.M., J.S., F.C.); Janssen Research & Development, Spring House, Pennsylvania (C.C.); and Janssen Research & Development, San Diego, California (P.W.)
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Caly Chien
Janssen Research & Development, Beerse, Belgium (R.d.V., F.J., G.M., J.S., F.C.); Janssen Research & Development, Spring House, Pennsylvania (C.C.); and Janssen Research & Development, San Diego, California (P.W.)
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Peter Ward
Janssen Research & Development, Beerse, Belgium (R.d.V., F.J., G.M., J.S., F.C.); Janssen Research & Development, Spring House, Pennsylvania (C.C.); and Janssen Research & Development, San Diego, California (P.W.)
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Article Information

vol. 47 no. 5 453-464
DOI 
https://doi.org/10.1124/dmd.118.084517
PubMed 
30787101

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 2, 2018
  • Accepted February 4, 2019
  • Published online March 28, 2019.

Article Versions

  • Earlier version (February 20, 2019 - 07:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ronald de Vries,
  2. Frank Jacobs,
  3. Geert Mannens,
  4. Jan Snoeys,
  5. Filip Cuyckens,
  6. Caly Chien, and
  7. Peter Ward
  1. Janssen Research & Development, Beerse, Belgium (R.d.V., F.J., G.M., J.S., F.C.); Janssen Research & Development, Spring House, Pennsylvania (C.C.); and Janssen Research & Development, San Diego, California (P.W.)
  1. Address correspondence to:
    Ronald de Vries, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium. E-mail: rdvries{at}its.jnj.com
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Drug Metabolism and Disposition: 47 (5)
Drug Metabolism and Disposition
Vol. 47, Issue 5
1 May 2019
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Research ArticleArticle

Apalutamide Human Absorption, Metabolism, and Excretion

Ronald de Vries, Frank Jacobs, Geert Mannens, Jan Snoeys, Filip Cuyckens, Caly Chien and Peter Ward
Drug Metabolism and Disposition May 1, 2019, 47 (5) 453-464; DOI: https://doi.org/10.1124/dmd.118.084517

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Research ArticleArticle

Apalutamide Human Absorption, Metabolism, and Excretion

Ronald de Vries, Frank Jacobs, Geert Mannens, Jan Snoeys, Filip Cuyckens, Caly Chien and Peter Ward
Drug Metabolism and Disposition May 1, 2019, 47 (5) 453-464; DOI: https://doi.org/10.1124/dmd.118.084517
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