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Research ArticleArticle

A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes

Keith A. Riccardi, David A. Tess, Jian Lin, Roshan Patel, Sangwoo Ryu, Karen Atkinson, Li Di and Rui Li
Drug Metabolism and Disposition May 2019, 47 (5) 484-492; DOI: https://doi.org/10.1124/dmd.118.085639
Keith A. Riccardi
Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.)
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David A. Tess
Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.)
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Jian Lin
Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.)
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Roshan Patel
Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.)
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Sangwoo Ryu
Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.)
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Karen Atkinson
Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.)
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Li Di
Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.)
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  • For correspondence: Li.Di@pfizer.com
Rui Li
Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.)
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  • For correspondence: Rui.Li5@pfizer.com
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Article Information

vol. 47 no. 5 484-492
DOI 
https://doi.org/10.1124/dmd.118.085639
PubMed 
30787098

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 24, 2018
  • Accepted February 5, 2019
  • Published online March 28, 2019.

Article Versions

  • Earlier version (February 20, 2019 - 07:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Keith A. Riccardi,
  2. David A. Tess,
  3. Jian Lin,
  4. Roshan Patel,
  5. Sangwoo Ryu,
  6. Karen Atkinson,
  7. Li Di⇑, and
  8. Rui Li⇑
  1. Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.)
  1. Address correspondence to:
    Dr. Li Di, Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, CT 06340. E-mail: Li.Di{at}pfizer.com; or
  2. Dr. Rui Li, Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, MA 02139. E-mail: Rui.Li5{at}pfizer.com
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Drug Metabolism and Disposition: 47 (5)
Drug Metabolism and Disposition
Vol. 47, Issue 5
1 May 2019
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Research ArticleArticle

IVIVE of Human Hepatic Clearance

Keith A. Riccardi, David A. Tess, Jian Lin, Roshan Patel, Sangwoo Ryu, Karen Atkinson, Li Di and Rui Li
Drug Metabolism and Disposition May 1, 2019, 47 (5) 484-492; DOI: https://doi.org/10.1124/dmd.118.085639

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Research ArticleArticle

IVIVE of Human Hepatic Clearance

Keith A. Riccardi, David A. Tess, Jian Lin, Roshan Patel, Sangwoo Ryu, Karen Atkinson, Li Di and Rui Li
Drug Metabolism and Disposition May 1, 2019, 47 (5) 484-492; DOI: https://doi.org/10.1124/dmd.118.085639
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