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Research ArticleArticle

Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors

Stephanie N. Liu, Jessica Bo Li Lu, Christy J. W. Watson, Philip Lazarus, Zeruesenay Desta and Brandon T. Gufford
Drug Metabolism and Disposition May 2019, 47 (5) 535-544; DOI: https://doi.org/10.1124/dmd.118.085035
Stephanie N. Liu
Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana (S.N.L., J.B.L.L., Z.D., B.T.G.) and Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (C.J.W.W., P.L.)
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Jessica Bo Li Lu
Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana (S.N.L., J.B.L.L., Z.D., B.T.G.) and Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (C.J.W.W., P.L.)
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Christy J. W. Watson
Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana (S.N.L., J.B.L.L., Z.D., B.T.G.) and Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (C.J.W.W., P.L.)
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Philip Lazarus
Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana (S.N.L., J.B.L.L., Z.D., B.T.G.) and Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (C.J.W.W., P.L.)
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Zeruesenay Desta
Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana (S.N.L., J.B.L.L., Z.D., B.T.G.) and Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (C.J.W.W., P.L.)
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Brandon T. Gufford
Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana (S.N.L., J.B.L.L., Z.D., B.T.G.) and Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (C.J.W.W., P.L.)
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Article Information

vol. 47 no. 5 535-544
DOI 
https://doi.org/10.1124/dmd.118.085035
PubMed 
30804050

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 22, 2018
  • Accepted February 21, 2019
  • Published online April 5, 2019.

Article Versions

  • Earlier version (February 25, 2019 - 10:26).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stephanie N. Liu,
  2. Jessica Bo Li Lu,
  3. Christy J. W. Watson,
  4. Philip Lazarus,
  5. Zeruesenay Desta, and
  6. Brandon T. Gufford
  1. Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana (S.N.L., J.B.L.L., Z.D., B.T.G.) and Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (C.J.W.W., P.L.)
  1. Address correspondence to:
    Dr. Zeruesenay Desta, Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, 950 West Walnut Street, R2, Room 425, Indianapolis, IN 46202-5188. E-mail: zdesta{at}iu.edu
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Drug Metabolism and Disposition: 47 (5)
Drug Metabolism and Disposition
Vol. 47, Issue 5
1 May 2019
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Research ArticleArticle

Glucuronidation of Integrase Strand Transfer Inhibitors

Stephanie N. Liu, Jessica Bo Li Lu, Christy J. W. Watson, Philip Lazarus, Zeruesenay Desta and Brandon T. Gufford
Drug Metabolism and Disposition May 1, 2019, 47 (5) 535-544; DOI: https://doi.org/10.1124/dmd.118.085035

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Research ArticleArticle

Glucuronidation of Integrase Strand Transfer Inhibitors

Stephanie N. Liu, Jessica Bo Li Lu, Christy J. W. Watson, Philip Lazarus, Zeruesenay Desta and Brandon T. Gufford
Drug Metabolism and Disposition May 1, 2019, 47 (5) 535-544; DOI: https://doi.org/10.1124/dmd.118.085035
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