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Drug Metabolism & Disposition

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Table of Contents

June 01, 2019; Volume 47,Issue 6

Commentary

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    Intracellular and Intraorgan Concentrations of Small Molecule Drugs: Theory, Uncertainties in Infectious Diseases and Oncology, and Promise
    Dennis A. Smith and Malcolm Rowland
    Drug Metabolism and Disposition June 2019, 47 (6) 665-672; DOI: https://doi.org/10.1124/dmd.118.085951

Minireview

  • Open Access
    Overview of the Components of Cardiac Metabolism
    Elizabeth A. Hausner, Susan A. Elmore and Xi Yang
    Drug Metabolism and Disposition June 2019, 47 (6) 673-688; DOI: https://doi.org/10.1124/dmd.119.086611

Articles

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    Impairment of Intestinal Monocarboxylate Transporter 6 Function and Expression in Diabetic Rats Induced by Combination of High-Fat Diet and Low Dose of Streptozocin: Involvement of Butyrate–Peroxisome Proliferator-Activated Receptor-γ Activation
    Feng Xu, Liang Zhu, Chaoqun Qian, Junjie Zhou, Donghao Geng, Ping Li, Wenjing Xuan, Fangge Wu, Kaijing Zhao, Weimin Kong, Yuanyuan Qin, Limin Liang, Li Liu and Xiaodong Liu
    Drug Metabolism and Disposition June 2019, 47 (6) 556-566; DOI: https://doi.org/10.1124/dmd.118.085803
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    Rolapitant Is a Reversible Inhibitor of CYP2D6
    Sarah M. Glass, Sabrina M. Leddy, Michael C. Orwin, Garret P. Miller, Kyle A. Furge and Laura Lowe Furge
    Drug Metabolism and Disposition June 2019, 47 (6) 567-573; DOI: https://doi.org/10.1124/dmd.118.085928
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    Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity
    Yu-Jie Chen, Jian Zhang, Ping-Ping Zhu, Xian-Wen Tan, Qiu-Hong Lin, Wen-Xia Wang, Shan-Shan Yin, Ling-Zhi Gao, Ming-Ming Su, Chang-Xiao Liu, Liang Xu, Wei Jia, Irina F. Sevrioukova and Ke Lan
    Drug Metabolism and Disposition June 2019, 47 (6) 574-581; DOI: https://doi.org/10.1124/dmd.119.086637
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    Maternal Plasma l-Carnitine Reduction During Pregnancy Is Mainly Attributed to OCTN2-Mediated Placental Uptake and Does Not Result in Maternal Hepatic Fatty Acid β-Oxidation Decline
    Mengru Bai, Qingquan Zeng, Yingchun Chen, Mingyang Chen, Ping Li, Zhiyuan Ma, Dongli Sun, Hui Zhou, Caihong Zheng, Su Zeng and Huidi Jiang
    Drug Metabolism and Disposition June 2019, 47 (6) 582-591; DOI: https://doi.org/10.1124/dmd.119.086439
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    Developmental Expression of the Cytosolic Sulfotransferases in Human Liver
    Sarah Dubaisi, Joseph A. Caruso, Roger Gaedigk, Carrie A. Vyhlidal, Philip C. Smith, Ronald N. Hines, Thomas A. Kocarek and Melissa Runge-Morris
    Drug Metabolism and Disposition June 2019, 47 (6) 592-600; DOI: https://doi.org/10.1124/dmd.119.086363
  • Open Access
    An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials
    C.J. Henderson, Y. Kapelyukh, N. Scheer, A. Rode, AW. McLaren, A.K. MacLeod, D. Lin, J. Wright, L.A. Stanley and C.R. Wolf
    Drug Metabolism and Disposition June 2019, 47 (6) 601-615; DOI: https://doi.org/10.1124/dmd.119.086397
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    Computational Prediction of the Site(s) of Metabolism and Binding Modes of Protein Kinase Inhibitors Metabolized by CYP3A4
    Pramod C. Nair, Ross A. McKinnon and John O. Miners
    Drug Metabolism and Disposition June 2019, 47 (6) 616-631; DOI: https://doi.org/10.1124/dmd.118.085167
  • Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells
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    Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells
    Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama and Hiroyuki Mizuguchi
    Drug Metabolism and Disposition June 2019, 47 (6) 632-638; DOI: https://doi.org/10.1124/dmd.119.086322
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    RNA Editing Enzymes Modulate the Expression of Hepatic CYP2B6, CYP2C8, and Other Cytochrome P450 Isoforms
    Kaori Nozaki, Masataka Nakano, Chika Iwakami, Tatsuki Fukami and Miki Nakajima
    Drug Metabolism and Disposition June 2019, 47 (6) 639-647; DOI: https://doi.org/10.1124/dmd.119.086702
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    Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy
    Philippe B. Pierrillas, Emilie Henin, Kathryn Ball, Julien Ogier, Magali Amiel, Laurence Kraus-Berthier, Marylore Chenel, François Bouzom and Michel Tod
    Drug Metabolism and Disposition June 2019, 47 (6) 648-656; DOI: https://doi.org/10.1124/dmd.118.085605
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    Mechanism of Reductive Metabolism and Chiral Inversion of Proton Pump Inhibitors
    Chongzhuang Tang, Zhaoqiang Chen, Xiaojian Dai, Weiliang Zhu, Dafang Zhong and Xiaoyan Chen
    Drug Metabolism and Disposition June 2019, 47 (6) 657-664; DOI: https://doi.org/10.1124/dmd.118.086090

Erratum

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    Correction to: Inhibition of Anthracycline Alcohol Metabolite Formation in Human Heart Cytosol: A Potential Role for Several Promising Drugs
    Drug Metabolism and Disposition June 2019, 47 (6) 689; DOI: https://doi.org/10.1124/dmd.115.065110err
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Drug Metabolism and Disposition: 47 (6)
Drug Metabolism and Disposition
Vol. 47, Issue 6
1 Jun 2019
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