Table of Contents

Articles

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  Impairment of Intestinal Monocarboxylate Transporter 6 Function and Expression in Diabetic Rats Induced by Combination of High-Fat Diet and Low Dose of Streptozocin: Involvement of Butyrate–Peroxisome Proliferator-Activated Receptor-γ Activation

  Feng Xu, Liang Zhu, Chaoqun Qian, Junjie Zhou, Donghao Geng, Ping Li, Wenjing Xuan, Fangge Wu, Kaijing Zhao, Weimin Kong, Yuanyuan Qin, Limin Liang, Li Liu and Xiaodong Liu

  Drug Metabolism and Disposition June 2019, 47 (6) 556-566; DOI: https://doi.org/10.1124/dmd.118.085803
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  Rolapitant Is a Reversible Inhibitor of CYP2D6

  Sarah M. Glass, Sabrina M. Leddy, Michael C. Orwin, Garret P. Miller, Kyle A. Furge and Laura Lowe Furge

  Drug Metabolism and Disposition June 2019, 47 (6) 567-573; DOI: https://doi.org/10.1124/dmd.118.085928
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  Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity

  Yu-Jie Chen, Jian Zhang, Ping-Ping Zhu, Xian-Wen Tan, Qiu-Hong Lin, Wen-Xia Wang, Shan-Shan Yin, Ling-Zhi Gao, Ming-Ming Su, Chang-Xiao Liu, Liang Xu, Wei Jia, Irina F. Sevrioukova and Ke Lan

  Drug Metabolism and Disposition June 2019, 47 (6) 574-581; DOI: https://doi.org/10.1124/dmd.119.086637
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  Maternal Plasma l-Carnitine Reduction During Pregnancy Is Mainly Attributed to OCTN2-Mediated Placental Uptake and Does Not Result in Maternal Hepatic Fatty Acid β-Oxidation Decline

  Mengru Bai, Qingquan Zeng, Yingchun Chen, Mingyang Chen, Ping Li, Zhiyuan Ma, Dongli Sun, Hui Zhou, Caihong Zheng, Su Zeng and Huidi Jiang

  Drug Metabolism and Disposition June 2019, 47 (6) 582-591; DOI: https://doi.org/10.1124/dmd.119.086439
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  Developmental Expression of the Cytosolic Sulfotransferases in Human Liver

  Sarah Dubaisi, Joseph A. Caruso, Roger Gaedigk, Carrie A. Vyhlidal, Philip C. Smith, Ronald N. Hines, Thomas A. Kocarek and Melissa Runge-Morris

  Drug Metabolism and Disposition June 2019, 47 (6) 592-600; DOI: https://doi.org/10.1124/dmd.119.086363
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  An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

  C.J. Henderson, Y. Kapelyukh, N. Scheer, A. Rode, AW. McLaren, A.K. MacLeod, D. Lin, J. Wright, L.A. Stanley and C.R. Wolf

  Drug Metabolism and Disposition June 2019, 47 (6) 601-615; DOI: https://doi.org/10.1124/dmd.119.086397
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  Computational Prediction of the Site(s) of Metabolism and Binding Modes of Protein Kinase Inhibitors Metabolized by CYP3A4

  Pramod C. Nair, Ross A. McKinnon and John O. Miners

  Drug Metabolism and Disposition June 2019, 47 (6) 616-631; DOI: https://doi.org/10.1124/dmd.118.085167
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  Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells

  Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama and Hiroyuki Mizuguchi

  Drug Metabolism and Disposition June 2019, 47 (6) 632-638; DOI: https://doi.org/10.1124/dmd.119.086322
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  RNA Editing Enzymes Modulate the Expression of Hepatic CYP2B6, CYP2C8, and Other Cytochrome P450 Isoforms

  Kaori Nozaki, Masataka Nakano, Chika Iwakami, Tatsuki Fukami and Miki Nakajima

  Drug Metabolism and Disposition June 2019, 47 (6) 639-647; DOI: https://doi.org/10.1124/dmd.119.086702
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  Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy

  Philippe B. Pierrillas, Emilie Henin, Kathryn Ball, Julien Ogier, Magali Amiel, Laurence Kraus-Berthier, Marylore Chenel, François Bouzom and Michel Tod

  Drug Metabolism and Disposition June 2019, 47 (6) 648-656; DOI: https://doi.org/10.1124/dmd.118.085605
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  Mechanism of Reductive Metabolism and Chiral Inversion of Proton Pump Inhibitors

  Chongzhuang Tang, Zhaoqiang Chen, Xiaojian Dai, Weiliang Zhu, Dafang Zhong and Xiaoyan Chen

  Drug Metabolism and Disposition June 2019, 47 (6) 657-664; DOI: https://doi.org/10.1124/dmd.118.086090