| | ng⋅h/ml | ng⋅h/ml | ng⋅h/ml | ng⋅h/ml | % | % | h | h | h | h | |
Chan et al. (1983) | | | | | | | | | | | | |
IR-MPH (N = 5) | 10 or 15 mg (oral) | N/A | N/A | N/A | N/A | 27.86 ± 11.48 Total d- + l-MPH (fasted)b | 27.86 ± 11.48 Total d- + l-MPH (fasted)b | 1.6 ± 0.4 | 1.6 ± 0.4 | 2.1 ± 0.4 | 2.1 ± 0.4 | Achiral TFA GC-MS |
IR-MPH (N = 5) | 10 or 15 mg (oral) | N/A | N/A | N/A | N/A | 31.40 ± 15.87 Total d- + l-MPH (fed) | 31.40 ± 15.87 Total d- + l-MPH (fed) | 1.0 ± 0.4 | 1.0 ± 0.4 | 2.1 ± 0.3 | 2.1 ± 0.3 | Achiral TFA GC-MS |
IR-MPH (N = 5) | 10 or 15 mg (i.v.) | N/A | N/A | N/A | N/A | 100 | 100 | 0.5 | 0.5 | 2.0 ± 0.4 | 2.0 ± 0.4 | Achiral TFA GC-MS |
Srinivas et al. (1987) | | | | | | | | | | | | |
IR-MPH (N = 5) | 10 mg (oral) | 9.00 (89% d-MPH) | 1.13 (89% d-MPH) | 30.46 ± 9.57 (82% d-MPH) | 6.66 ± 1.38 (82% d-MPH) | N/A | N/A | 2.2 ± 0.5 | 2.01 ± 1.16 | 3.1 ± 1.1 | 5.59 ± 1.07 | Chiral HFB-GC-ECD |
Srinivas et al. (1992) | | | | | | | | | | | | |
IR-MPH (N = 9) | 10 mg (oral) | 7.43 (83% d-MPH) | 1.50 (83% d-MPH) | 27.71 ± 9.53 (86% d-MPH) | 4.61 ± 1.77 (86% d-MPH) | N/A | N/A | 2.3 ± 0.5 | 2.4 ± 0.5 | 1.87 ± 0.65 | 1.43 ± 0.76 | Chiral HFB-GC-ECD |
Srinivas et al. (1993) | | | | | | | | | | | | |
IR-MPH (N = 13) | 40 mg (oral) | 19.50 (84% d-MPH) | 3.75 (84% d-MPH) | 120.21 ± 30.68 (89% d-MPH) | 14.79 ± 4.14 (89% d-MPH) | 23 (82%) | 5 (18%) | 2.4 ± 0.8 | 2.14 ± 0.64 | 5.7 ± 1.2 | 3.93 ± 0.76 | Chiral HFB-GC-ECD |
IR-MPH (N = 11) | 10 mg (i.v.) | 15.00 (56% d-MPH) | 12.00 (56% d-MPH) | 147.74 ± 47.91 (63% d-MPH) | 88.64 ± 43.13 (63% d-MPH) | 100 | 100 | 0.25 | 0.25 | 6.0 ± 1.7 | 3.61 ± 1.12 | Chiral HFB-GC-ECD |
Modi et al. (2000b) | | | | | | | | | | | | |
OROS-MPH (N = 33) | 18 mg (oral) | 2.25 (99% d-MPH) | 0.03 (99% d-MPH) | 42.2 ± 16 (99% d-MPH) | 0.43 ± 0.7 (99% d-MPH) | N/A | N/A | 7.9 ± 2.0 | 7.1 ± 2.0 | 3.8 ± 0.8 | N/A | Chiral LC-MS |
Patrick et al. (2007) | | | | | | | | | | | | |
IR-MPH (N = 19) | 0.3 mg/kg (oral) | 20.25 (98% d-MPH) | 0.38 (98% d-MPH) | 82.9 ± 26.2 (N/A) | N/A | N/A | N/A | 2.3 ± 32.7 | 3 | 2.8 ± 14.3 | N/A | Chiral LC-MS |
Patrick et al. (2013) | | | | | | | | | | | | |
IR-MPH (N = 24) | 0.15 mg/kg (oral) | 25.10 (99% d-MPH | 0.27 (99% d-MPH) | 52.1 ± 29 (99% d-MPH) | 0.77 ± 73 (99% d-MPH) | N/A | N/A | 2.4 ± 47 | 1.8 ± 49 | 2.9 ± 19 | 2.1 ± 41 | Chiral LC-MS |