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Drug Metabolism & Disposition

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Table of Contents

August 01, 2019; Volume 47,Issue 8

Articles

  • Activation of Pregnane X Receptor–Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo
    You have access
    Activation of Pregnane X Receptor–Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo
    Fengling Wang, Huihui Wang, Yifan Wu, Lei Wang, Ling Zhang, Xi Ye, Daiyin Peng and Weidong Chen
    Drug Metabolism and Disposition August 2019, 47 (8) 785-793; DOI: https://doi.org/10.1124/dmd.119.086769
  • Enhanced Platelet Response to Clopidogrel in Zucker Diabetic Fatty Rats due to Impaired Clopidogrel Inactivation by Carboxylesterase 1 and Increased Exposure to Active Metabolite
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    Enhanced Platelet Response to Clopidogrel in Zucker Diabetic Fatty Rats due to Impaired Clopidogrel Inactivation by Carboxylesterase 1 and Increased Exposure to Active Metabolite
    Hongwei Yao, Ruifeng Bai, Tianming Ren, Yani Wang, Jingkai Gu and Yingjie Guo
    Drug Metabolism and Disposition August 2019, 47 (8) 794-801; DOI: https://doi.org/10.1124/dmd.118.085126
  • You have access
    Identification of Novel Metabolites of Vildagliptin in Rats: Thiazoline-Containing Thiol Adducts Formed via Cysteine or Glutathione Conjugation
    Katsuhiko Mizuno, Kenji Takeuchi, Ken Umehara and Miki Nakajima
    Drug Metabolism and Disposition August 2019, 47 (8) 809-817; DOI: https://doi.org/10.1124/dmd.119.086546
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    Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism
    Mayur K. Ladumor, Deepak Kumar Bhatt, Andrea Gaedigk, Sheena Sharma, Aarzoo Thakur, Robin E. Pearce, J. Steven Leeder, Michael B. Bolger, Saranjit Singh and Bhagwat Prasad
    Drug Metabolism and Disposition August 2019, 47 (8) 818-831; DOI: https://doi.org/10.1124/dmd.119.086462
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    Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1
    Samantha Medwid, Mandy M.J. Li, Michael J. Knauer, Kathleen Lin, Sara E. Mansell, Crystal L. Schmerk, Catherine Zhu, Katelyn E. Griffin, Mohamed D. Yousif, George K. Dresser, Ute I. Schwarz, Richard B. Kim and Rommel G. Tirona
    Drug Metabolism and Disposition August 2019, 47 (8) 832-842; DOI: https://doi.org/10.1124/dmd.119.087619
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    Carboxylesterase 2 and Intestine Transporters Contribute to the Low Bioavailability of Allisartan, a Prodrug of Exp3174 for Hypertension Treatment in Humans
    Xiuli Li, Jingchao Sun, Zitao Guo, Dafang Zhong and Xiaoyan Chen
    Drug Metabolism and Disposition August 2019, 47 (8) 843-853; DOI: https://doi.org/10.1124/dmd.118.085092
  • The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis
    Open Access
    The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis
    Matthew D. Harwood, Mian Zhang, Shriram M. Pathak and Sibylle Neuhoff
    Drug Metabolism and Disposition August 2019, 47 (8) 854-864; DOI: https://doi.org/10.1124/dmd.119.086959
  • Open Access
    Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs
    Philip Gardiner, Rhona J. Cox and Ken Grime
    Drug Metabolism and Disposition August 2019, 47 (8) 865-873; DOI: https://doi.org/10.1124/dmd.119.087163
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    Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach
    Sravani Adusumalli, Rohitash Jamwal, R. Scott Obach, Tim F. Ryder, Lorenzo Leggio and Fatemeh Akhlaghi
    Drug Metabolism and Disposition August 2019, 47 (8) 874-882; DOI: https://doi.org/10.1124/dmd.119.087015
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    Carfilzomib Is Not an Appropriate Payload of Antibody-Drug Conjugates Due to Rapid Inactivation by Lysosomal Enzymes
    Yong Ma, Josefa Dela Cruz-Chuh, S. Cyrus Khojasteh, Peter S. Dragovich, Thomas H. Pillow and Donglu Zhang
    Drug Metabolism and Disposition August 2019, 47 (8) 884-889; DOI: https://doi.org/10.1124/dmd.119.086595
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    Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways
    Maciej J. Zamek-Gliszczynski, Xuexiang Zhang, Jennypher Mudunuru, Yewei Du, Jian-Lu Chen, Kunal S. Taskar, Jane Huang, Yong Huang and Elizabeth H. Romach
    Drug Metabolism and Disposition August 2019, 47 (8) 890-898; DOI: https://doi.org/10.1124/dmd.119.087635
  • Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease
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    Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease
    Jacqueline Bezençon, James J. Beaudoin, Katsuaki Ito, Dong Fu, Sharin E. Roth, William J. Brock and Kim L.R. Brouwer
    Drug Metabolism and Disposition August 2019, 47 (8) 899-906; DOI: https://doi.org/10.1124/dmd.119.086785
  • Open Access
    Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice
    Y. Kapelyukh, C. J. Henderson, N. Scheer, A. Rode and C. R. Wolf
    Drug Metabolism and Disposition August 2019, 47 (8) 907-918; DOI: https://doi.org/10.1124/dmd.119.087718
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    Nitidine Chloride–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism
    Xu Mao, Jian Wang, Qian Wang, Lan Yang, Yilin Li, Hao Lin, Ying Peng and Jiang Zheng
    Drug Metabolism and Disposition August 2019, 47 (8) 919-927; DOI: https://doi.org/10.1124/dmd.119.086892
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    Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome–Related Aqueous Metabolites in Mice
    David K. Scoville, Cindy Yanfei Li, Dongfang Wang, Joseph L. Dempsey, Daniel Raftery, Sridhar Mani, Haiwei Gu and Julia Yue Cui
    Drug Metabolism and Disposition August 2019, 47 (8) 928-940; DOI: https://doi.org/10.1124/dmd.119.086538

Short Communication

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    Kidney Cortical Transporter Expression across Species Using Quantitative Proteomics
    Abdul Basit, Zaher Radi, Vishal S. Vaidya, Matthew Karasu and Bhagwat Prasad
    Drug Metabolism and Disposition August 2019, 47 (8) 802-808; DOI: https://doi.org/10.1124/dmd.119.086579

Erratum

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    Correction to “Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader”
    Drug Metabolism and Disposition August 2019, 47 (8) 883; DOI: https://doi.org/10.1124/dmd.119.081539err
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Drug Metabolism and Disposition: 47 (8)
Drug Metabolism and Disposition
Vol. 47, Issue 8
1 Aug 2019
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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