Table of Contents

Articles

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  Activation of Pregnane X Receptor–Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo

  Fengling Wang, Huihui Wang, Yifan Wu, Lei Wang, Ling Zhang, Xi Ye, Daiyin Peng and Weidong Chen

  Drug Metabolism and Disposition August 2019, 47 (8) 785-793; DOI: https://doi.org/10.1124/dmd.119.086769
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  Enhanced Platelet Response to Clopidogrel in Zucker Diabetic Fatty Rats due to Impaired Clopidogrel Inactivation by Carboxylesterase 1 and Increased Exposure to Active Metabolite

  Hongwei Yao, Ruifeng Bai, Tianming Ren, Yani Wang, Jingkai Gu and Yingjie Guo

  Drug Metabolism and Disposition August 2019, 47 (8) 794-801; DOI: https://doi.org/10.1124/dmd.118.085126
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  Identification of Novel Metabolites of Vildagliptin in Rats: Thiazoline-Containing Thiol Adducts Formed via Cysteine or Glutathione Conjugation

  Katsuhiko Mizuno, Kenji Takeuchi, Ken Umehara and Miki Nakajima

  Drug Metabolism and Disposition August 2019, 47 (8) 809-817; DOI: https://doi.org/10.1124/dmd.119.086546
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  Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism

  Mayur K. Ladumor, Deepak Kumar Bhatt, Andrea Gaedigk, Sheena Sharma, Aarzoo Thakur, Robin E. Pearce, J. Steven Leeder, Michael B. Bolger, Saranjit Singh and Bhagwat Prasad

  Drug Metabolism and Disposition August 2019, 47 (8) 818-831; DOI: https://doi.org/10.1124/dmd.119.086462
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  Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1

  Samantha Medwid, Mandy M.J. Li, Michael J. Knauer, Kathleen Lin, Sara E. Mansell, Crystal L. Schmerk, Catherine Zhu, Katelyn E. Griffin, Mohamed D. Yousif, George K. Dresser, Ute I. Schwarz, Richard B. Kim and Rommel G. Tirona

  Drug Metabolism and Disposition August 2019, 47 (8) 832-842; DOI: https://doi.org/10.1124/dmd.119.087619
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  Carboxylesterase 2 and Intestine Transporters Contribute to the Low Bioavailability of Allisartan, a Prodrug of Exp3174 for Hypertension Treatment in Humans

  Xiuli Li, Jingchao Sun, Zitao Guo, Dafang Zhong and Xiaoyan Chen

  Drug Metabolism and Disposition August 2019, 47 (8) 843-853; DOI: https://doi.org/10.1124/dmd.118.085092
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  The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis

  Matthew D. Harwood, Mian Zhang, Shriram M. Pathak and Sibylle Neuhoff

  Drug Metabolism and Disposition August 2019, 47 (8) 854-864; DOI: https://doi.org/10.1124/dmd.119.086959
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  Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs

  Philip Gardiner, Rhona J. Cox and Ken Grime

  Drug Metabolism and Disposition August 2019, 47 (8) 865-873; DOI: https://doi.org/10.1124/dmd.119.087163
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  Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach

  Sravani Adusumalli, Rohitash Jamwal, R. Scott Obach, Tim F. Ryder, Lorenzo Leggio and Fatemeh Akhlaghi

  Drug Metabolism and Disposition August 2019, 47 (8) 874-882; DOI: https://doi.org/10.1124/dmd.119.087015
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  Carfilzomib Is Not an Appropriate Payload of Antibody-Drug Conjugates Due to Rapid Inactivation by Lysosomal Enzymes

  Yong Ma, Josefa Dela Cruz-Chuh, S. Cyrus Khojasteh, Peter S. Dragovich, Thomas H. Pillow and Donglu Zhang

  Drug Metabolism and Disposition August 2019, 47 (8) 884-889; DOI: https://doi.org/10.1124/dmd.119.086595
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  Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways

  Maciej J. Zamek-Gliszczynski, Xuexiang Zhang, Jennypher Mudunuru, Yewei Du, Jian-Lu Chen, Kunal S. Taskar, Jane Huang, Yong Huang and Elizabeth H. Romach

  Drug Metabolism and Disposition August 2019, 47 (8) 890-898; DOI: https://doi.org/10.1124/dmd.119.087635
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  Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease

  Jacqueline Bezençon, James J. Beaudoin, Katsuaki Ito, Dong Fu, Sharin E. Roth, William J. Brock and Kim L.R. Brouwer

  Drug Metabolism and Disposition August 2019, 47 (8) 899-906; DOI: https://doi.org/10.1124/dmd.119.086785
• Open Access

  Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

  Y. Kapelyukh, C. J. Henderson, N. Scheer, A. Rode and C. R. Wolf

  Drug Metabolism and Disposition August 2019, 47 (8) 907-918; DOI: https://doi.org/10.1124/dmd.119.087718
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  Nitidine Chloride–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism

  Xu Mao, Jian Wang, Qian Wang, Lan Yang, Yilin Li, Hao Lin, Ying Peng and Jiang Zheng

  Drug Metabolism and Disposition August 2019, 47 (8) 919-927; DOI: https://doi.org/10.1124/dmd.119.086892
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  Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome–Related Aqueous Metabolites in Mice

  David K. Scoville, Cindy Yanfei Li, Dongfang Wang, Joseph L. Dempsey, Daniel Raftery, Sridhar Mani, Haiwei Gu and Julia Yue Cui

  Drug Metabolism and Disposition August 2019, 47 (8) 928-940; DOI: https://doi.org/10.1124/dmd.119.086538