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Drug Metabolism & Disposition

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Table of Contents

September 01, 2019; Volume 47,Issue 9

Articles

  • You have access
    Plasma Protein and Lipoprotein Binding of Cis- and Trans-Permethrin and Deltamethrin in Adult Humans and Rats
    Pankaj Sethi, James V. Bruckner, Tanzir B. Mortuza, Brian S. Cummings, Srinivasa Muralidhara and Catherine A. White
    Drug Metabolism and Disposition September 2019, 47 (9) 941-948; DOI: https://doi.org/10.1124/dmd.118.085464
  • You have access
    Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics
    Lenka Tupova, Martina Ceckova, Csilla Ambrus, Ales Sorf, Zuzana Ptackova, Zsuzsanna Gaborik and Frantisek Staud
    Drug Metabolism and Disposition September 2019, 47 (9) 954-960; DOI: https://doi.org/10.1124/dmd.119.087684
  • Arylacetamide Deacetylase Enzyme: Presence and Interindividual Variability in Human Lungs
    You have access
    Arylacetamide Deacetylase Enzyme: Presence and Interindividual Variability in Human Lungs
    Morena Gabriele, Paola Puccini, Marco Lucchi, Vittorio Aprile, Pier Giovanni Gervasi and Vincenzo Longo
    Drug Metabolism and Disposition September 2019, 47 (9) 961-965; DOI: https://doi.org/10.1124/dmd.119.087031
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    GDC-0810 Pharmacokinetics and Transporter-Mediated Drug Interaction Evaluation with an Endogenous Biomarker in the First-in-Human, Dose Escalation Study
    Kit Wun Kathy Cheung, Kenta Yoshida, Sravanthi Cheeti, Buyun Chen, Roland Morley, Iris T. Chan, Srikumar Sahasranaman and Lichuan Liu
    Drug Metabolism and Disposition September 2019, 47 (9) 966-973; DOI: https://doi.org/10.1124/dmd.119.087924
  • Specificity of the Redox Complex between Cytochrome P450 24A1 and Adrenodoxin Relies on Carbon-25 Hydroxylation of Vitamin-D Substrate
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    Specificity of the Redox Complex between Cytochrome P450 24A1 and Adrenodoxin Relies on Carbon-25 Hydroxylation of Vitamin-D Substrate
    Amit Kumar and D. Fernando Estrada
    Drug Metabolism and Disposition September 2019, 47 (9) 974-982; DOI: https://doi.org/10.1124/dmd.119.087759
  • Open Access
    Single Nucleotide Polymorphisms at a Distance from Aryl Hydrocarbon Receptor (AHR) Binding Sites Influence AHR Ligand–Dependent Gene Expression
    Drew R. Neavin, Jeong-Heon Lee, Duan Liu, Zhenqing Ye, Hu Li, Liewei Wang, Tamas Ordog and Richard M. Weinshilboum
    Drug Metabolism and Disposition September 2019, 47 (9) 983-994; DOI: https://doi.org/10.1124/dmd.119.087312
  • Open Access
    Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates
    M.N. Lombardo, N. G-Dayanandan, S. Keshipeddy, W. Zhou, D. Si, S.M. Reeve, J. Alverson, P. Barney, L. Walker, J. Hoody, N.D. Priestley, R.S. Obach and D.L. Wright
    Drug Metabolism and Disposition September 2019, 47 (9) 995-1003; DOI: https://doi.org/10.1124/dmd.119.086504
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    The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats
    Yuu Moriya, Akifumi Kogame, Yoshihiko Tagawa, Akio Morohashi, Takahiro Kondo, Satoru Asahi and Leslie Z. Benet
    Drug Metabolism and Disposition September 2019, 47 (9) 1004-1012; DOI: https://doi.org/10.1124/dmd.119.087148

Short Communication

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    SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells
    Mohammed I. Hossain, Joshua M. Marcus, Jun Hee Lee, Patrick L. Garcia, Jean-Philippe Gagné, Guy G. Poirier, Charles N. Falany and Shaida A. Andrabi
    Drug Metabolism and Disposition September 2019, 47 (9) 949-953; DOI: https://doi.org/10.1124/dmd.119.088047
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In this issue

Drug Metabolism and Disposition: 47 (9)
Drug Metabolism and Disposition
Vol. 47, Issue 9
1 Sep 2019
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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