Research ArticleArticle
The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats
Yuu Moriya, Akifumi Kogame, Yoshihiko Tagawa, Akio Morohashi, Takahiro Kondo, Satoru Asahi and Leslie Z. Benet
Drug Metabolism and Disposition September 2019, 47 (9) 1004-1012; DOI: https://doi.org/10.1124/dmd.119.087148
Yuu Moriya
Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (Y.M., A.K., Y.T., A.M., S.A.); Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, Osaka, Japan (T.K.); and University of California San Francisco, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, San Francisco, California (L.Z.B.)
Akifumi Kogame
Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (Y.M., A.K., Y.T., A.M., S.A.); Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, Osaka, Japan (T.K.); and University of California San Francisco, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, San Francisco, California (L.Z.B.)
Yoshihiko Tagawa
Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (Y.M., A.K., Y.T., A.M., S.A.); Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, Osaka, Japan (T.K.); and University of California San Francisco, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, San Francisco, California (L.Z.B.)
Akio Morohashi
Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (Y.M., A.K., Y.T., A.M., S.A.); Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, Osaka, Japan (T.K.); and University of California San Francisco, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, San Francisco, California (L.Z.B.)
Takahiro Kondo
Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (Y.M., A.K., Y.T., A.M., S.A.); Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, Osaka, Japan (T.K.); and University of California San Francisco, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, San Francisco, California (L.Z.B.)
Satoru Asahi
Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (Y.M., A.K., Y.T., A.M., S.A.); Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, Osaka, Japan (T.K.); and University of California San Francisco, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, San Francisco, California (L.Z.B.)
Leslie Z. Benet
Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (Y.M., A.K., Y.T., A.M., S.A.); Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, Osaka, Japan (T.K.); and University of California San Francisco, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, San Francisco, California (L.Z.B.)
Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleArticle
Nonlinear Pharmacokinetics of TAK-448 in Rats
Yuu Moriya, Akifumi Kogame, Yoshihiko Tagawa, Akio Morohashi, Takahiro Kondo, Satoru Asahi and Leslie Z. Benet
Drug Metabolism and Disposition September 1, 2019, 47 (9) 1004-1012; DOI: https://doi.org/10.1124/dmd.119.087148
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement