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Drug Metabolism & Disposition

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Table of Contents

October 01, 2020; Volume 48,Issue 10

Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions

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    Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
    Mary F. Paine
    Drug Metabolism and Disposition October 2020, 48 (10) 956-962; DOI: https://doi.org/10.1124/dmd.120.000182
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    National Center for Complementary and Integrative Health Perspectives on Clinical Research Involving Natural Products
    Wendy J. Weber and D. Craig Hopp
    Drug Metabolism and Disposition October 2020, 48 (10) 963-965; DOI: https://doi.org/10.1124/dmd.120.000071
  • Multidrug Resistance–Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood
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    Multidrug Resistance–Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood
    Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai and Hong-Guang Xie
    Drug Metabolism and Disposition October 2020, 48 (10) 966-971; DOI: https://doi.org/10.1124/dmd.119.089193
  • The Effects of Traditional Chinese Medicine on P-Glycoprotein–Mediated Multidrug Resistance and Approaches for Studying the Herb–P-Glycoprotein Interactions
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    The Effects of Traditional Chinese Medicine on P-Glycoprotein–Mediated Multidrug Resistance and Approaches for Studying the Herb–P-Glycoprotein Interactions
    Yuhong Cao, Yiwei Shi, Ying Cai, Zhanying Hong and Yifeng Chai
    Drug Metabolism and Disposition October 2020, 48 (10) 972-979; DOI: https://doi.org/10.1124/dmd.120.000050
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    In Vitro Human Cell–Based Experimental Models for the Evaluation of Enteric Metabolism and Drug Interaction Potential of Drugs and Natural Products
    Albert P. Li
    Drug Metabolism and Disposition October 2020, 48 (10) 980-992; DOI: https://doi.org/10.1124/dmd.120.000053
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    Natural Products as Modulators of CES1 Activity
    Yuli Qian and John S. Markowitz
    Drug Metabolism and Disposition October 2020, 48 (10) 993-1007; DOI: https://doi.org/10.1124/dmd.120.000065
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    Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450
    Sumit Bansal, Neha Maharao, Mary F. Paine and Jashvant D. Unadkat
    Drug Metabolism and Disposition October 2020, 48 (10) 1008-1017; DOI: https://doi.org/10.1124/dmd.120.000073
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    Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects
    Matthew G. McDonald, Dan-Dan Tian, Kenneth E. Thummel, Mary F. Paine and Allan E. Rettie
    Drug Metabolism and Disposition October 2020, 48 (10) 1018-1027; DOI: https://doi.org/10.1124/dmd.120.091041
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    Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde
    Michael J. Espiritu, Justin Chen, Jaydeep Yadav, Michael Larkin, Robert D. Pelletier, Jeannine M. Chan, Jeevan B. GC, Senthil Natesan and John P. Harrelson
    Drug Metabolism and Disposition October 2020, 48 (10) 1028-1043; DOI: https://doi.org/10.1124/dmd.120.000087
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    Influence of Zuojin Pill on the Metabolism of Venlafaxine in Vitro and in Rats and Associated Herb-Drug Interaction
    Yue Li, Juan Li, Dongmin Yan, Qian Wang, Jingyi Jin, Bo Tan and Furong Qiu
    Drug Metabolism and Disposition October 2020, 48 (10) 1044-1052; DOI: https://doi.org/10.1124/dmd.120.000048
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    Centella asiatica Water Extract Shows Low Potential for Cytochrome P450–Mediated Drug Interactions
    Kirsten M. Wright, Armando Alcazar Magana, Ronald M. Laethem, Caroline L. Moseley, Troy T. Banks, Claudia S. Maier, Jan F. Stevens, Joseph F. Quinn and Amala Soumyanath
    Drug Metabolism and Disposition October 2020, 48 (10) 1053-1063; DOI: https://doi.org/10.1124/dmd.120.090860
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    Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters
    Violetta Mohos, Eszter Fliszár-Nyúl, Orsolya Ungvári, Éva Bakos, Katalin Kuffa, Tímea Bencsik, Balázs Zoltán Zsidó, Csaba Hetényi, Ágnes Telbisz, Csilla Özvegy-Laczka and Miklós Poór
    Drug Metabolism and Disposition October 2020, 48 (10) 1064-1073; DOI: https://doi.org/10.1124/dmd.120.000085
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    Organic Cation Transporter 1 and 3 Contribute to the High Accumulation of Dehydrocorydaline in the Heart
    Yingchun Chen, Cui Li, Yaodong Yi, Weijuan Du, Huidi Jiang, Su Zeng and Hui Zhou
    Drug Metabolism and Disposition October 2020, 48 (10) 1074-1083; DOI: https://doi.org/10.1124/dmd.120.000025
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    Application of Cryopreserved Human Intestinal Mucosa and Cryopreserved Human Enterocytes in the Evaluation of Herb-Drug Interactions: Evaluation of CYP3A Inhibitory Potential of Grapefruit Juice and Commercial Formulations of Twenty-Nine Herbal Supplements
    Carol Loretz, Ming-Chih David Ho, Novera Alam, Walter Mitchell and Albert P. Li
    Drug Metabolism and Disposition October 2020, 48 (10) 1084-1091; DOI: https://doi.org/10.1124/dmd.120.000033
  • Multiomics Profiling Reveals Protective Function of <em>Schisandra</em> Lignans against Acetaminophen-Induced Hepatotoxicity
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    Multiomics Profiling Reveals Protective Function of Schisandra Lignans against Acetaminophen-Induced Hepatotoxicity
    Caixia Yan, Huimin Guo, Qingqing Ding, Yuhao Shao, Dian Kang, Tengjie Yu, Changjian Li, Haoran Huang, Yisha Du, He Wang, Kangrui Hu, Lin Xie, Guangji Wang and Yan Liang
    Drug Metabolism and Disposition October 2020, 48 (10) 1092-1103; DOI: https://doi.org/10.1124/dmd.120.000083
  • Open Access
    A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: From Chemical Characterization to Clinical Studies
    Caroline Birer-Williams, Brandon T. Gufford, Eric Chou, Marijanel Alilio, Sidney VanAlstine, Rachael E. Morley, Jeannine S. McCune, Mary F. Paine and Richard D. Boyce
    Drug Metabolism and Disposition October 2020, 48 (10) 1104-1112; DOI: https://doi.org/10.1124/dmd.120.000054

Articles

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    Detection of Weak Organic Anion–Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans
    Yueping Zhang, Vinay K. Holenarsipur, Hamza Kandoussi, Jianing Zeng, T. Thanga Mariappan, Michael Sinz and Hong Shen
    Drug Metabolism and Disposition October 2020, 48 (10) 841-848; DOI: https://doi.org/10.1124/dmd.120.000076
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    Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction
    Kenichi Umehara, Carina Cantrill, Matthias Beat Wittwer, Elisa Di Lenarda, Florian Klammers, Aynur Ekiciler, Neil Parrott, Stephen Fowler and Mohammed Ullah
    Drug Metabolism and Disposition October 2020, 48 (10) 849-860; DOI: https://doi.org/10.1124/dmd.120.000133
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    Comparison of In Vitro to In Vivo Extrapolation Approaches for Predicting Transporter-Mediated Hepatic Uptake Clearance Using Suspended Rat Hepatocytes
    Na Li, Akshay Badrinarayanan, Xingwen Li, John Roberts, Mike Hayashi, Manpreet Virk and Anshul Gupta
    Drug Metabolism and Disposition October 2020, 48 (10) 861-872; DOI: https://doi.org/10.1124/dmd.120.000064
  • Open Access
    Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite
    Ulrike Glaenzel, Yi Jin, Regine Hansen, Kirsten Schroer, Gholamreza Rahmanzadeh, Ulrike Pfaar, Jan Jaap van Lier, Hubert Borell, Axel Meissner, Gian Camenisch and Sylvia Zhao
    Drug Metabolism and Disposition October 2020, 48 (10) 873-885; DOI: https://doi.org/10.1124/dmd.119.090324
  • Preclinical Transplacental Transfer and Pharmacokinetics of Fipronil in Rats
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    Preclinical Transplacental Transfer and Pharmacokinetics of Fipronil in Rats
    Ya-Ning Chang and Tung-Hu Tsai
    Drug Metabolism and Disposition October 2020, 48 (10) 886-893; DOI: https://doi.org/10.1124/dmd.120.000088
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    Seeking Nonspecific Binding: Assessing the Reliability of Tissue Dilutions for Calculating Fraction Unbound
    William J. Jusko, Emilie A.G. Molins and Vivaswath S. Ayyar
    Drug Metabolism and Disposition October 2020, 48 (10) 894-902; DOI: https://doi.org/10.1124/dmd.120.000118
  • Open Access
    Quantification of the Impact of Partition Coefficient Prediction Methods on Physiologically Based Pharmacokinetic Model Output Using a Standardized Tissue Composition
    Kiersten Utsey, Madeleine S. Gastonguay, Sean Russell, Reed Freling, Matthew M. Riggs and Ahmed Elmokadem
    Drug Metabolism and Disposition October 2020, 48 (10) 903-916; DOI: https://doi.org/10.1124/dmd.120.090498
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    A Study of the Effect of Cyclosporine on Fevipiprant Pharmacokinetics and its Absolute Bioavailability Using an Intravenous Microdose Approach
    H. Markus Weiss, Ken-Ichi Umehara, Veit J. Erpenbeck, Meredith Cain, Janardhana Vemula, Walid Elbast and Markus Zollinger
    Drug Metabolism and Disposition October 2020, 48 (10) 917-924; DOI: https://doi.org/10.1124/dmd.120.090852
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    Quantification of Neonatal Fc Receptor and Beta-2 Microglobulin in Human Liver Tissues by Ultraperformance Liquid Chromatography–Multiple Reaction Monitoring–based Targeted Quantitative Proteomics for Applications in Biotherapeutic Physiologically-based Pharmacokinetic Models
    Xiazi Qiu and Michael Zhuo Wang
    Drug Metabolism and Disposition October 2020, 48 (10) 925-933; DOI: https://doi.org/10.1124/dmd.120.000075
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    Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver
    Suguru Kato, Abhi Shah, Mihaela Plesescu, Yoshinari Miyata, Jayaprakasam Bolleddula, Swapan Chowdhury and Xiaochun Zhu
    Drug Metabolism and Disposition October 2020, 48 (10) 934-943; DOI: https://doi.org/10.1124/dmd.120.000128
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    Human Amyloid-β40 Kinetics after Intravenous and Intracerebroventricular Injections and Calcitriol Treatment in Rats In Vivo
    H. Benson Peng, Keumhan Noh, Sophie R. Pan, Victor Saldivia, Sylvia Serson, Anja Toscan, Inés A.M. de Lannoy and K. Sandy Pang
    Drug Metabolism and Disposition October 2020, 48 (10) 944-955; DOI: https://doi.org/10.1124/dmd.120.090886
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Drug Metabolism and Disposition: 48 (10)
Drug Metabolism and Disposition
Vol. 48, Issue 10
1 Oct 2020
  • Table of Contents
  • Table of Contents (PDF)
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  • Index by author
  • Editorial Board (PDF)
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  • Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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