Drug Metabolism and Disposition: 48 (10)

October 01, 2020; Volume 48,Issue 10

Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions

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Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Mary F. Paine

Drug Metabolism and Disposition October 2020, 48 (10) 956-962; DOI: https://doi.org/10.1124/dmd.120.000182
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National Center for Complementary and Integrative Health Perspectives on Clinical Research Involving Natural Products
Wendy J. Weber and D. Craig Hopp

Drug Metabolism and Disposition October 2020, 48 (10) 963-965; DOI: https://doi.org/10.1124/dmd.120.000071
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Multidrug Resistance–Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood
Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai and Hong-Guang Xie

Drug Metabolism and Disposition October 2020, 48 (10) 966-971; DOI: https://doi.org/10.1124/dmd.119.089193
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The Effects of Traditional Chinese Medicine on P-Glycoprotein–Mediated Multidrug Resistance and Approaches for Studying the Herb–P-Glycoprotein Interactions
Yuhong Cao, Yiwei Shi, Ying Cai, Zhanying Hong and Yifeng Chai

Drug Metabolism and Disposition October 2020, 48 (10) 972-979; DOI: https://doi.org/10.1124/dmd.120.000050
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In Vitro Human Cell–Based Experimental Models for the Evaluation of Enteric Metabolism and Drug Interaction Potential of Drugs and Natural Products
Albert P. Li

Drug Metabolism and Disposition October 2020, 48 (10) 980-992; DOI: https://doi.org/10.1124/dmd.120.000053
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Natural Products as Modulators of CES1 Activity
Yuli Qian and John S. Markowitz

Drug Metabolism and Disposition October 2020, 48 (10) 993-1007; DOI: https://doi.org/10.1124/dmd.120.000065
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Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450
Sumit Bansal, Neha Maharao, Mary F. Paine and Jashvant D. Unadkat

Drug Metabolism and Disposition October 2020, 48 (10) 1008-1017; DOI: https://doi.org/10.1124/dmd.120.000073
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Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects
Matthew G. McDonald, Dan-Dan Tian, Kenneth E. Thummel, Mary F. Paine and Allan E. Rettie

Drug Metabolism and Disposition October 2020, 48 (10) 1018-1027; DOI: https://doi.org/10.1124/dmd.120.091041
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Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde
Michael J. Espiritu, Justin Chen, Jaydeep Yadav, Michael Larkin, Robert D. Pelletier, Jeannine M. Chan, Jeevan B. GC, Senthil Natesan and John P. Harrelson

Drug Metabolism and Disposition October 2020, 48 (10) 1028-1043; DOI: https://doi.org/10.1124/dmd.120.000087
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Influence of Zuojin Pill on the Metabolism of Venlafaxine in Vitro and in Rats and Associated Herb-Drug Interaction
Yue Li, Juan Li, Dongmin Yan, Qian Wang, Jingyi Jin, Bo Tan and Furong Qiu

Drug Metabolism and Disposition October 2020, 48 (10) 1044-1052; DOI: https://doi.org/10.1124/dmd.120.000048
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Centella asiatica Water Extract Shows Low Potential for Cytochrome P450–Mediated Drug Interactions
Kirsten M. Wright, Armando Alcazar Magana, Ronald M. Laethem, Caroline L. Moseley, Troy T. Banks, Claudia S. Maier, Jan F. Stevens, Joseph F. Quinn and Amala Soumyanath

Drug Metabolism and Disposition October 2020, 48 (10) 1053-1063; DOI: https://doi.org/10.1124/dmd.120.090860
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Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters
Violetta Mohos, Eszter Fliszár-Nyúl, Orsolya Ungvári, Éva Bakos, Katalin Kuffa, Tímea Bencsik, Balázs Zoltán Zsidó, Csaba Hetényi, Ágnes Telbisz, Csilla Özvegy-Laczka and Miklós Poór

Drug Metabolism and Disposition October 2020, 48 (10) 1064-1073; DOI: https://doi.org/10.1124/dmd.120.000085
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Organic Cation Transporter 1 and 3 Contribute to the High Accumulation of Dehydrocorydaline in the Heart
Yingchun Chen, Cui Li, Yaodong Yi, Weijuan Du, Huidi Jiang, Su Zeng and Hui Zhou

Drug Metabolism and Disposition October 2020, 48 (10) 1074-1083; DOI: https://doi.org/10.1124/dmd.120.000025
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Application of Cryopreserved Human Intestinal Mucosa and Cryopreserved Human Enterocytes in the Evaluation of Herb-Drug Interactions: Evaluation of CYP3A Inhibitory Potential of Grapefruit Juice and Commercial Formulations of Twenty-Nine Herbal Supplements
Carol Loretz, Ming-Chih David Ho, Novera Alam, Walter Mitchell and Albert P. Li

Drug Metabolism and Disposition October 2020, 48 (10) 1084-1091; DOI: https://doi.org/10.1124/dmd.120.000033
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Multiomics Profiling Reveals Protective Function of Schisandra Lignans against Acetaminophen-Induced Hepatotoxicity
Caixia Yan, Huimin Guo, Qingqing Ding, Yuhao Shao, Dian Kang, Tengjie Yu, Changjian Li, Haoran Huang, Yisha Du, He Wang, Kangrui Hu, Lin Xie, Guangji Wang and Yan Liang

Drug Metabolism and Disposition October 2020, 48 (10) 1092-1103; DOI: https://doi.org/10.1124/dmd.120.000083
Open Access
A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: From Chemical Characterization to Clinical Studies
Caroline Birer-Williams, Brandon T. Gufford, Eric Chou, Marijanel Alilio, Sidney VanAlstine, Rachael E. Morley, Jeannine S. McCune, Mary F. Paine and Richard D. Boyce

Drug Metabolism and Disposition October 2020, 48 (10) 1104-1112; DOI: https://doi.org/10.1124/dmd.120.000054

Articles

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Detection of Weak Organic Anion–Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans
Yueping Zhang, Vinay K. Holenarsipur, Hamza Kandoussi, Jianing Zeng, T. Thanga Mariappan, Michael Sinz and Hong Shen

Drug Metabolism and Disposition October 2020, 48 (10) 841-848; DOI: https://doi.org/10.1124/dmd.120.000076
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Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction
Kenichi Umehara, Carina Cantrill, Matthias Beat Wittwer, Elisa Di Lenarda, Florian Klammers, Aynur Ekiciler, Neil Parrott, Stephen Fowler and Mohammed Ullah

Drug Metabolism and Disposition October 2020, 48 (10) 849-860; DOI: https://doi.org/10.1124/dmd.120.000133
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Comparison of In Vitro to In Vivo Extrapolation Approaches for Predicting Transporter-Mediated Hepatic Uptake Clearance Using Suspended Rat Hepatocytes
Na Li, Akshay Badrinarayanan, Xingwen Li, John Roberts, Mike Hayashi, Manpreet Virk and Anshul Gupta

Drug Metabolism and Disposition October 2020, 48 (10) 861-872; DOI: https://doi.org/10.1124/dmd.120.000064
Open Access
Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite
Ulrike Glaenzel, Yi Jin, Regine Hansen, Kirsten Schroer, Gholamreza Rahmanzadeh, Ulrike Pfaar, Jan Jaap van Lier, Hubert Borell, Axel Meissner, Gian Camenisch and Sylvia Zhao

Drug Metabolism and Disposition October 2020, 48 (10) 873-885; DOI: https://doi.org/10.1124/dmd.119.090324
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Preclinical Transplacental Transfer and Pharmacokinetics of Fipronil in Rats
Ya-Ning Chang and Tung-Hu Tsai

Drug Metabolism and Disposition October 2020, 48 (10) 886-893; DOI: https://doi.org/10.1124/dmd.120.000088
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Seeking Nonspecific Binding: Assessing the Reliability of Tissue Dilutions for Calculating Fraction Unbound
William J. Jusko, Emilie A.G. Molins and Vivaswath S. Ayyar

Drug Metabolism and Disposition October 2020, 48 (10) 894-902; DOI: https://doi.org/10.1124/dmd.120.000118
Open Access
Quantification of the Impact of Partition Coefficient Prediction Methods on Physiologically Based Pharmacokinetic Model Output Using a Standardized Tissue Composition
Kiersten Utsey, Madeleine S. Gastonguay, Sean Russell, Reed Freling, Matthew M. Riggs and Ahmed Elmokadem

Drug Metabolism and Disposition October 2020, 48 (10) 903-916; DOI: https://doi.org/10.1124/dmd.120.090498
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A Study of the Effect of Cyclosporine on Fevipiprant Pharmacokinetics and its Absolute Bioavailability Using an Intravenous Microdose Approach
H. Markus Weiss, Ken-Ichi Umehara, Veit J. Erpenbeck, Meredith Cain, Janardhana Vemula, Walid Elbast and Markus Zollinger

Drug Metabolism and Disposition October 2020, 48 (10) 917-924; DOI: https://doi.org/10.1124/dmd.120.090852
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Quantification of Neonatal Fc Receptor and Beta-2 Microglobulin in Human Liver Tissues by Ultraperformance Liquid Chromatography–Multiple Reaction Monitoring–based Targeted Quantitative Proteomics for Applications in Biotherapeutic Physiologically-based Pharmacokinetic Models
Xiazi Qiu and Michael Zhuo Wang

Drug Metabolism and Disposition October 2020, 48 (10) 925-933; DOI: https://doi.org/10.1124/dmd.120.000075
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Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver
Suguru Kato, Abhi Shah, Mihaela Plesescu, Yoshinari Miyata, Jayaprakasam Bolleddula, Swapan Chowdhury and Xiaochun Zhu

Drug Metabolism and Disposition October 2020, 48 (10) 934-943; DOI: https://doi.org/10.1124/dmd.120.000128
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Human Amyloid-β₄₀ Kinetics after Intravenous and Intracerebroventricular Injections and Calcitriol Treatment in Rats In Vivo
H. Benson Peng, Keumhan Noh, Sophie R. Pan, Victor Saldivia, Sylvia Serson, Anja Toscan, Inés A.M. de Lannoy and K. Sandy Pang

Drug Metabolism and Disposition October 2020, 48 (10) 944-955; DOI: https://doi.org/10.1124/dmd.120.090886

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