Research ArticleSpecial Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde
Michael J. Espiritu, Justin Chen, Jaydeep Yadav, Michael Larkin, Robert D. Pelletier, Jeannine M. Chan, Jeevan B. GC, Senthil Natesan and John P. Harrelson
Drug Metabolism and Disposition October 2020, 48 (10) 1028-1043; DOI: https://doi.org/10.1124/dmd.120.000087
Michael J. Espiritu
School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.)
Justin Chen
School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.)
Jaydeep Yadav
School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.)
Michael Larkin
School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.)
Robert D. Pelletier
School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.)
Jeannine M. Chan
School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.)
Jeevan B. GC
School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.)
Senthil Natesan
School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.)
John P. Harrelson
School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (M.J.E., M.L., J.P.H.); College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (J.C., J.B.G., S.N.); Amgen, Cambridge, Massachusetts (J.Y.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (R.D.P.); and Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.M.C.)
Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleSpecial Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Interactions between 2A6 and Natural Products in Cinnamon
Michael J. Espiritu, Justin Chen, Jaydeep Yadav, Michael Larkin, Robert D. Pelletier, Jeannine M. Chan, Jeevan B. GC, Senthil Natesan and John P. Harrelson
Drug Metabolism and Disposition October 1, 2020, 48 (10) 1028-1043; DOI: https://doi.org/10.1124/dmd.120.000087
Research ArticleSpecial Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Interactions between 2A6 and Natural Products in Cinnamon
Michael J. Espiritu, Justin Chen, Jaydeep Yadav, Michael Larkin, Robert D. Pelletier, Jeannine M. Chan, Jeevan B. GC, Senthil Natesan and John P. Harrelson
Drug Metabolism and Disposition October 1, 2020, 48 (10) 1028-1043; DOI: https://doi.org/10.1124/dmd.120.000087
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement