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Research ArticleSpecial Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions — Short Communication

Multidrug Resistance–Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood

Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai and Hong-Guang Xie
Drug Metabolism and Disposition October 2020, 48 (10) 966-971; DOI: https://doi.org/10.1124/dmd.119.089193
Yu-Meng Jia
Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China (Y.-M.J., J.-Z.J., T.T., H.-G.X.); Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China (Y.-M.J., T.Z., H.Z., H.-G.X.); and Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy, Nanjing, People’s Republic of China (H.-G.X.)
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Ting Zhu
Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China (Y.-M.J., J.-Z.J., T.T., H.-G.X.); Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China (Y.-M.J., T.Z., H.Z., H.-G.X.); and Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy, Nanjing, People’s Republic of China (H.-G.X.)
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Huan Zhou
Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China (Y.-M.J., J.-Z.J., T.T., H.-G.X.); Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China (Y.-M.J., T.Z., H.Z., H.-G.X.); and Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy, Nanjing, People’s Republic of China (H.-G.X.)
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Jin-Zi Ji
Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China (Y.-M.J., J.-Z.J., T.T., H.-G.X.); Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China (Y.-M.J., T.Z., H.Z., H.-G.X.); and Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy, Nanjing, People’s Republic of China (H.-G.X.)
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Ting Tai
Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China (Y.-M.J., J.-Z.J., T.T., H.-G.X.); Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China (Y.-M.J., T.Z., H.Z., H.-G.X.); and Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy, Nanjing, People’s Republic of China (H.-G.X.)
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Hong-Guang Xie
Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China (Y.-M.J., J.-Z.J., T.T., H.-G.X.); Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China (Y.-M.J., T.Z., H.Z., H.-G.X.); and Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy, Nanjing, People’s Republic of China (H.-G.X.)
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Article Information

vol. 48 no. 10 966-971
DOI 
https://doi.org/10.1124/dmd.119.089193
PubMed 
31900255

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 27, 2019
  • Accepted December 18, 2019
  • Published online September 22, 2020.

Article Versions

  • Earlier version (January 3, 2020 - 02:25).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yu-Meng Jia,
  2. Ting Zhu,
  3. Huan Zhou,
  4. Jin-Zi Ji,
  5. Ting Tai, and
  6. Hong-Guang Xie
  1. Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China (Y.-M.J., J.-Z.J., T.T., H.-G.X.); Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China (Y.-M.J., T.Z., H.Z., H.-G.X.); and Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy, Nanjing, People’s Republic of China (H.-G.X.)
  1. Address correspondence to:
    Dr. Hong-Guang Xie, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, People’s Republic of China. E-mail: hongg.xie{at}gmail.com
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Drug Metabolism and Disposition: 48 (10)
Drug Metabolism and Disposition
Vol. 48, Issue 10
1 Oct 2020
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Research ArticleSpecial Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions — Short Communication

MRP3 Transports Curcumin Glucuronide

Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai and Hong-Guang Xie
Drug Metabolism and Disposition October 1, 2020, 48 (10) 966-971; DOI: https://doi.org/10.1124/dmd.119.089193

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Research ArticleSpecial Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions — Short Communication

MRP3 Transports Curcumin Glucuronide

Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai and Hong-Guang Xie
Drug Metabolism and Disposition October 1, 2020, 48 (10) 966-971; DOI: https://doi.org/10.1124/dmd.119.089193
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