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Review ArticleSpecial Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions — Minireview

The Effects of Traditional Chinese Medicine on P-Glycoprotein–Mediated Multidrug Resistance and Approaches for Studying the Herb–P-Glycoprotein Interactions

Yuhong Cao, Yiwei Shi, Ying Cai, Zhanying Hong and Yifeng Chai
Drug Metabolism and Disposition October 2020, 48 (10) 972-979; DOI: https://doi.org/10.1124/dmd.120.000050
Yuhong Cao
School of Pharmacy, Second Military Medical University, Shanghai Key Laboratory for Pharmaceutical (Chinese Materia Medica) Metabolites Research, Shanghai, China (Yu.C., Y.S., Yi.C., Z.H., Y.Ch.) and School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China (Yi.C.)
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Yiwei Shi
School of Pharmacy, Second Military Medical University, Shanghai Key Laboratory for Pharmaceutical (Chinese Materia Medica) Metabolites Research, Shanghai, China (Yu.C., Y.S., Yi.C., Z.H., Y.Ch.) and School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China (Yi.C.)
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Ying Cai
School of Pharmacy, Second Military Medical University, Shanghai Key Laboratory for Pharmaceutical (Chinese Materia Medica) Metabolites Research, Shanghai, China (Yu.C., Y.S., Yi.C., Z.H., Y.Ch.) and School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China (Yi.C.)
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Zhanying Hong
School of Pharmacy, Second Military Medical University, Shanghai Key Laboratory for Pharmaceutical (Chinese Materia Medica) Metabolites Research, Shanghai, China (Yu.C., Y.S., Yi.C., Z.H., Y.Ch.) and School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China (Yi.C.)
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Yifeng Chai
School of Pharmacy, Second Military Medical University, Shanghai Key Laboratory for Pharmaceutical (Chinese Materia Medica) Metabolites Research, Shanghai, China (Yu.C., Y.S., Yi.C., Z.H., Y.Ch.) and School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China (Yi.C.)
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Drug Metabolism and Disposition: 48 (10)
Drug Metabolism and Disposition
Vol. 48, Issue 10
1 Oct 2020
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Review ArticleSpecial Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions — Minireview

TCM Natural Products as P-gp–Mediated MDR Reversal Agents

Yuhong Cao, Yiwei Shi, Ying Cai, Zhanying Hong and Yifeng Chai
Drug Metabolism and Disposition October 1, 2020, 48 (10) 972-979; DOI: https://doi.org/10.1124/dmd.120.000050

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Review ArticleSpecial Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions — Minireview

TCM Natural Products as P-gp–Mediated MDR Reversal Agents

Yuhong Cao, Yiwei Shi, Ying Cai, Zhanying Hong and Yifeng Chai
Drug Metabolism and Disposition October 1, 2020, 48 (10) 972-979; DOI: https://doi.org/10.1124/dmd.120.000050
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    • Visual Overview
    • Abstract
    • Introduction
    • Development of P-gp Inhibitors in MDR Modulation
    • Traditional Chinese Medicine Modulation of P-gp
    • Approaches for Studying the Interaction of P-gp and TCM
    • Conclusions and Outlook
    • Authorship Contributions
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