Table of Contents

Articles

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  The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites

  Brian D. Chapron, Jean C. Dinh, Paul C. Toren, Andrea Gaedigk and J. Steven Leeder

  Drug Metabolism and Disposition November 2020, 48 (11) 1113-1120; DOI: https://doi.org/10.1124/dmd.120.000188
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  (–)-N-3-Benzylphenobarbital Is Superior to Omeprazole and (+)-N-3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes

  Marie-Lynn Cuypers, Hugues Chanteux, Eric Gillent, Pierre Bonnaillie, Kenneth Saunders, Claire Beckers, Claude Delatour, Sylvie Dell’Aiera, Anna-Lena Ungell and Johan Nicolaï

  Drug Metabolism and Disposition November 2020, 48 (11) 1121-1128; DOI: https://doi.org/10.1124/dmd.120.000089
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  Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model

  Jian Lu, Ang Chen, Xinrun Ma, Xuyang Shang, Yuanjin Zhang, Yuanqing Guo, Mingyao Liu and Xin Wang

  Drug Metabolism and Disposition November 2020, 48 (11) 1129-1136; DOI: https://doi.org/10.1124/dmd.120.000114
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  Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance

  Beth Williamson, Stephanie Harlfinger and Dermot F. McGinnity

  Drug Metabolism and Disposition November 2020, 48 (11) 1137-1146; DOI: https://doi.org/10.1124/dmd.120.000131
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  A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery

  Michael J. Hafey, Robert Houle, Keith Q. Tanis, Ian Knemeyer, Jackie Shang, Qing Chen, Andreas Baudy, James Monroe, Frank D. Sistare and Raymond Evers

  Drug Metabolism and Disposition November 2020, 48 (11) 1147-1160; DOI: https://doi.org/10.1124/dmd.120.000086
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  Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti–Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats

  Hao Cai, Victor Yip, M. Violet Lee, Sylvia Wong, Ola Saad, Shuguang Ma, Nina Ljumanovic, S. Cyrus Khojasteh, Amrita V. Kamath and Ben-Quan Shen

  Drug Metabolism and Disposition November 2020, 48 (11) 1161-1168; DOI: https://doi.org/10.1124/dmd.120.000092
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  Evaluation of In Vitro Models for Assessment of Human Intestinal Metabolism in Drug Discovery

  Mari Davies, Prabha Peramuhendige, Lloyd King, Melanie Golding, Apoorva Kotian, Mark Penney, Syeda Shah and Nenad Manevski

  Drug Metabolism and Disposition November 2020, 48 (11) 1169-1182; DOI: https://doi.org/10.1124/dmd.120.000111
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  Impact of P-Glycoprotein–Mediated Active Efflux on Drug Distribution into Lumbar Cerebrospinal Fluid in Nonhuman Primates

  Yoko Nagaya, Kazuhide Katayama, Hiroyuki Kusuhara and Yoshitane Nozaki

  Drug Metabolism and Disposition November 2020, 48 (11) 1183-1190; DOI: https://doi.org/10.1124/dmd.120.000099
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  Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport

  Jonathan B. Wagner, Melissa Ruggiero, J. Steven Leeder and Bruno Hagenbuch

  Drug Metabolism and Disposition November 2020, 48 (11) 1192-1198; DOI: https://doi.org/10.1124/dmd.120.000122
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  Characterization of Seasonal Pharmacokinetic Variability in Woodchucks

  Jim Zheng, Scott Balsitis, Rex Santos, Bill J. Smith and Raju Subramanian

  Drug Metabolism and Disposition November 2020, 48 (11) 1199-1209; DOI: https://doi.org/10.1124/dmd.120.000140
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  Successful Prediction of Positron Emission Tomography–Imaged Metformin Hepatic Uptake Clearance in Humans Using the Quantitative Proteomics–Informed Relative Expression Factor Approach

  Madhav Sachar, Vineet Kumar, Lars C. Gormsen, Ole Lajord Munk and Jashvant D. Unadkat

  Drug Metabolism and Disposition November 2020, 48 (11) 1210-1216; DOI: https://doi.org/10.1124/dmd.120.000156
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  Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats

  Edwin J. Squirewell, Marci G. Smeltz, Laura Rowland-Faux, Lloyd P. Horne, Peter W. Stacpoole and Margaret O. James

  Drug Metabolism and Disposition November 2020, 48 (11) 1217-1223; DOI: https://doi.org/10.1124/dmd.120.000142
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  Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1

  Edwin J. Squirewell, Ricky Mareus, Lloyd P. Horne, Peter W. Stacpoole and Margaret O. James

  Drug Metabolism and Disposition November 2020, 48 (11) 1224-1230; DOI: https://doi.org/10.1124/dmd.120.000143
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  A Laboratory-Specific Scaling Factor to Predict the In Vivo Human Clearance of Aldehyde Oxidase Substrates

  Mailys De Sousa Mendes, Alexandra L. Orton, Helen E. Humphries, Barry Jones, Iain Gardner, Sibylle Neuhoff and Venkatesh Pilla Reddy

  Drug Metabolism and Disposition November 2020, 48 (11) 1231-1238; DOI: https://doi.org/10.1124/dmd.120.000082
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  Pharmacokinetics and Catabolism of [³H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate

  Jayaprakasam Bolleddula, Abhi Shah, Mohammad Shadid, Afrand Kamali, Michael D. Smith and Swapan K. Chowdhury

  Drug Metabolism and Disposition November 2020, 48 (11) 1239-1245; DOI: https://doi.org/10.1124/dmd.120.000194