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Drug Metabolism & Disposition

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Table of Contents

November 01, 2020; Volume 48,Issue 11

Announcement

  • You have access
    Announcement
    Dr. Emily E. Scott
    Drug Metabolism and Disposition November 2020, 48 (11) 1191; DOI: https://doi.org/10.1124/dmd.120.000249

Articles

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    The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites
    Brian D. Chapron, Jean C. Dinh, Paul C. Toren, Andrea Gaedigk and J. Steven Leeder
    Drug Metabolism and Disposition November 2020, 48 (11) 1113-1120; DOI: https://doi.org/10.1124/dmd.120.000188
  • (–)-<em>N</em>-3-Benzylphenobarbital Is Superior to Omeprazole and (+)-<em>N</em>-3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes
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    (–)-N-3-Benzylphenobarbital Is Superior to Omeprazole and (+)-N-3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes
    Marie-Lynn Cuypers, Hugues Chanteux, Eric Gillent, Pierre Bonnaillie, Kenneth Saunders, Claire Beckers, Claude Delatour, Sylvie Dell’Aiera, Anna-Lena Ungell and Johan Nicolaï
    Drug Metabolism and Disposition November 2020, 48 (11) 1121-1128; DOI: https://doi.org/10.1124/dmd.120.000089
  • Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model
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    Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model
    Jian Lu, Ang Chen, Xinrun Ma, Xuyang Shang, Yuanjin Zhang, Yuanqing Guo, Mingyao Liu and Xin Wang
    Drug Metabolism and Disposition November 2020, 48 (11) 1129-1136; DOI: https://doi.org/10.1124/dmd.120.000114
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    Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance
    Beth Williamson, Stephanie Harlfinger and Dermot F. McGinnity
    Drug Metabolism and Disposition November 2020, 48 (11) 1137-1146; DOI: https://doi.org/10.1124/dmd.120.000131
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    A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery
    Michael J. Hafey, Robert Houle, Keith Q. Tanis, Ian Knemeyer, Jackie Shang, Qing Chen, Andreas Baudy, James Monroe, Frank D. Sistare and Raymond Evers
    Drug Metabolism and Disposition November 2020, 48 (11) 1147-1160; DOI: https://doi.org/10.1124/dmd.120.000086
  • Open Access
    Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti–Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats
    Hao Cai, Victor Yip, M. Violet Lee, Sylvia Wong, Ola Saad, Shuguang Ma, Nina Ljumanovic, S. Cyrus Khojasteh, Amrita V. Kamath and Ben-Quan Shen
    Drug Metabolism and Disposition November 2020, 48 (11) 1161-1168; DOI: https://doi.org/10.1124/dmd.120.000092
  • Evaluation of In Vitro Models for Assessment of Human Intestinal Metabolism in Drug Discovery
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    Evaluation of In Vitro Models for Assessment of Human Intestinal Metabolism in Drug Discovery
    Mari Davies, Prabha Peramuhendige, Lloyd King, Melanie Golding, Apoorva Kotian, Mark Penney, Syeda Shah and Nenad Manevski
    Drug Metabolism and Disposition November 2020, 48 (11) 1169-1182; DOI: https://doi.org/10.1124/dmd.120.000111
  • Impact of P-Glycoprotein–Mediated Active Efflux on Drug Distribution into Lumbar Cerebrospinal Fluid in Nonhuman Primates
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    Impact of P-Glycoprotein–Mediated Active Efflux on Drug Distribution into Lumbar Cerebrospinal Fluid in Nonhuman Primates
    Yoko Nagaya, Kazuhide Katayama, Hiroyuki Kusuhara and Yoshitane Nozaki
    Drug Metabolism and Disposition November 2020, 48 (11) 1183-1190; DOI: https://doi.org/10.1124/dmd.120.000099
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    Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport
    Jonathan B. Wagner, Melissa Ruggiero, J. Steven Leeder and Bruno Hagenbuch
    Drug Metabolism and Disposition November 2020, 48 (11) 1192-1198; DOI: https://doi.org/10.1124/dmd.120.000122
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    Characterization of Seasonal Pharmacokinetic Variability in Woodchucks
    Jim Zheng, Scott Balsitis, Rex Santos, Bill J. Smith and Raju Subramanian
    Drug Metabolism and Disposition November 2020, 48 (11) 1199-1209; DOI: https://doi.org/10.1124/dmd.120.000140
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    Successful Prediction of Positron Emission Tomography–Imaged Metformin Hepatic Uptake Clearance in Humans Using the Quantitative Proteomics–Informed Relative Expression Factor Approach
    Madhav Sachar, Vineet Kumar, Lars C. Gormsen, Ole Lajord Munk and Jashvant D. Unadkat
    Drug Metabolism and Disposition November 2020, 48 (11) 1210-1216; DOI: https://doi.org/10.1124/dmd.120.000156
  • Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats
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    Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats
    Edwin J. Squirewell, Marci G. Smeltz, Laura Rowland-Faux, Lloyd P. Horne, Peter W. Stacpoole and Margaret O. James
    Drug Metabolism and Disposition November 2020, 48 (11) 1217-1223; DOI: https://doi.org/10.1124/dmd.120.000142
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    Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1
    Edwin J. Squirewell, Ricky Mareus, Lloyd P. Horne, Peter W. Stacpoole and Margaret O. James
    Drug Metabolism and Disposition November 2020, 48 (11) 1224-1230; DOI: https://doi.org/10.1124/dmd.120.000143
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    A Laboratory-Specific Scaling Factor to Predict the In Vivo Human Clearance of Aldehyde Oxidase Substrates
    Mailys De Sousa Mendes, Alexandra L. Orton, Helen E. Humphries, Barry Jones, Iain Gardner, Sibylle Neuhoff and Venkatesh Pilla Reddy
    Drug Metabolism and Disposition November 2020, 48 (11) 1231-1238; DOI: https://doi.org/10.1124/dmd.120.000082
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    Pharmacokinetics and Catabolism of [3H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate
    Jayaprakasam Bolleddula, Abhi Shah, Mohammad Shadid, Afrand Kamali, Michael D. Smith and Swapan K. Chowdhury
    Drug Metabolism and Disposition November 2020, 48 (11) 1239-1245; DOI: https://doi.org/10.1124/dmd.120.000194

Erratum

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    Correction to “Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators”
    Drug Metabolism and Disposition November 2020, 48 (11) 1246; DOI: https://doi.org/10.1124/dmd.119.089680err
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Drug Metabolism and Disposition: 48 (11)
Drug Metabolism and Disposition
Vol. 48, Issue 11
1 Nov 2020
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